The purpose of this presentation is to report: (a) the finding of very high titers of isoagglutinins in patients with horse serum disease, (b) the finding of very low titers in patients with chronic leukemias, (c) the failure to influence the titer of isoagglutinins by the introduction of large quantities of blood as well as by removal of similar quantities. To provide standards of comparison, the titers of isoagglutinins were studied in a series of 517 persons.
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