Objective To explore the effect of red lip defect repair using orbicularis oris muscles pedicle island flap disc. Methods 100 cases of unilateral pure red lip defect 1/3-2/3, lip lines full of patients were selected as the research subjects. They were randomly divided into two groups, 50 cases in each group. Group A treated with debridement surgery to repair. Group B received red lip flap to promote repair treatment. The treatment effect of the two groups, satisfaction, lip survival rate and the degree of obvious scars were compared. Results he operation effect of the two groups was good. The satisfaction rates of group A and group B were 94.00% and 96.00%, respectively.For the lip shape treatment satisfaction, the difference was no statistically significant (P>0.05). The patients of the two groups with lip all alive, and 1 patient in group A with obvious scar, the scar was not obvious in group B. Conclusion For patients with red lip defect, take orbicularis oris muscles pedicle island flap of the oral mucosa or red lip flap to promote repair treatment has relatively significant clinical efficacy, with easy operation, less influence on the patients with facial form, it is worthy of popularizing. Key words: Oral mucosal flap; Red lip defect; Repair; Orbicularisoris muscles island