Evidence from terrestrial sections, ice cores, and marine cores are reviewed and used to develop a scenario for environmental change in the area of the extreme northwest North Atlantic during marine isotope stages 5 and 4. The critical physical link between the landbased glacial chronology and marine events in Baffin Bay is the presence of carbonate rich drift along the Baffin Bay coast of Bylot Island and a detrital carbonate facies (Facies B) in Baffin Bay sediments. Cores from Baffin Bay/Labrador Sea can be dated by means of oxygen isotope variations and by peaks in the abundance of volcanic glass shards. One occurrence of Facies B is dated between late stage 5 and stage 4 and we correlate this event with the Eclipse Glaciation of Bylot Island and the Ayr Lake stade of the Foxe Glaciation of Baffin Island (= Kogalu aminozone). In contrast on West Greenland, amino acid racemization evidence suggests that the Greenland Ice Sheet developed throughout stage 4 and reached a maximum in stage 3 (Svartenhuk advance >40 ka). The oxygen isotope record in the Devon Island Ice Cap (northwest Baffin Bay) indicates that Baffin Bay was largely open during marine isotope stage 5. Analyses of shallow water molluscan and foraminiferal assemblages, deep-water foraminifera, pollen from Iand sections and deep-sea cores, and dinoflagellates from marine cores indicate that interglacial conditions prevailed during much of the stage 54 glaciation.