This study aimed to relate self-knowledge to mental health (from Islamic perspective), and compare it among the female students. Using the Morgan table, we selected 379 students from four universities, namely alzahra University, a single-sex university, the University of Tehran, Shahid Beheshti University, and Kharazmi University. The samples were selected randomly by applying a stratified sampling method. We utilized two instruments: Islamic self-knowledge and general mental health questionnaires. The collected data were analyzed using Pearson Correlation Coefficient, independent samples t-test, and linear regression analysis using SPSS version 25. The results showed that there were significant association between self-knowledge and mental health. However, there were no significant differences between the female students of humanities and sciences, whether from the point of self-knowledge or mental health. The results also showed no significant differences between the students of alzahra University and the female students of the other three universities in self-knowledge and mental health. In each case, the results are compared to Islamic viewpoints (Quran, Hadith, and Quotations from various Islamic thinkers) as well as the psychological viewpoints of Maslow and Rogers. Our findings underline the importance of enhancing self-knowledge among female university students as a protective factor against mental health outcomes (substance abuse, depression, and anxiety) Moreover, Faith based strategies are known to be effective, more accessible than mental health professional services and will carry less stigma in the target community.
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