This study examines the transformation of policy toward Islam in Uzbekistan during the Gorbachev era. It considers both Moscow's policy and, as Uzbekistan began to achieve greater control over its own affairs, the policy of the republic's leaders. The article begins by placing the changes in policy toward Islam in the broader context of emerging Soviet policy toward religion during the middle of the 1960s. It then examines some of the All-Union and republic communist parties’ concessions toward Islam and attempts to use Islam in addressing the most pressing cultural, social, economic, and political problems facing Uzbekistan. The study pays particular attention to the official religious establishment and briefly explores its role in efforts by Uzbekistan's political leadership to maintain political control.