Patients using a wheelchair often experience the ischial pain and/or the pressure sores by the long-term sitting posture and the continuous ischial pressure. Moreover, patients with paralytic severe scoliosis need TLSOs to be applied, which produces the compression around inguinal, causing legs swelling. In order to relieve ischial pain and legs swelling of patients using wheelchair, several methods for weight support are investigated, and it is shown that both ischial pressure and inguinal compression can be effectively reduced by using a suitable orthosis in conjunction with a wheelchair. Developed TLSO with weight-supporting function will be reported in the conference.