Reperfusion of an acutely ischemic tissue is recognized to elicit an intense inflammatory response that causes tissue injury. The mechanisms of reperfusion injury are multifactorial, including all the biochemical and molecular events following ischemia. While restoration of blood flow is essential in ameliorating the progression of cellular injury associated with decreased oxygen and nutrient delivery, it is also followed by a series of complex reactions that paradoxically injures tissue [1–3]. Ischemic liver injury is a significant problem in clinical medicine that can occur as a consequence of circulatory shock or hepatic surgery (trauma, tumor resection, or liver transplantation) and may lead to local and organ systemic dysfunction. The purpose of this review is to analyze all important changes associated with the response of cell adhesion molecules (CAMs) after hepatic ischemia/reperfusion (I/R) injury.