Annotation. Ischemic heart disease (IHD) is one of the main causes of high mortality, disability and a decrease in the quality of life of the working-age population (WAP) in Ukraine. Aim of the work: to determine the modern features of mortality, disability, prevalence and incidence of ischemic heart disease in the working-age population of the Kyiv region. The analysis of the epidemiology of IHD in the Kyiv region was carried out in dynamics for 2010–2019 and compared to Ukraine. The statistical data of the State Statistics Committee of Ukraine, the Center for Medical Statistics of the Ministry of Health of Ukraine, and the Kyiv Regional Center for Medical Statistics on mortality, disability, prevalence and incidence of IHD in the working-age population of the Kyiv region were analyzed with the medical-statistical method. It has been established that IHD is a significant cause of the loss of labor potential in the Kyiv region. IHD accounts for every fourth (25.0%) death in the working age, and the regional level of working-age population mortality from IHD is the highest in Ukraine. In the Kyiv region working-age population dies from ischemic heart disease 1.5–1.7 times, and from myocardial infarction – 1.7–1.9 times more often than the average in Ukraine. Regional levels of incidence IHD among working-age population exceed similar indicators in Ukraine by 1.2 times, the incidence of myocardial infarction – 1.5 times, the prevalence of ischemic heart disease – 1.7 times. Identified unfavorable dynamic trends in mortality and prevalence of IHD among the working-age population of the Kyiv region. The mortality rate from IHD among working-age population increased in the Kyiv region in 2019 compared to 2010, by 7.9%. The prevalence of IHD increased during 2010–2018 by 14.4%, and the primary incidence of myocardial infarction – by 14.9%. The unfavorable epidemiological situation with IHD among working-age population in the Kyiv region necessitates improving the system for the prevention and the organization of medical care for patients with IHD in this region.