Aim. The aim of the research was to improve the elements of agro-technology for cultivating new high-yielding varieties of winter wheat under conditions of the plain zone irrigation depending on the doses and the terms of introducing mineral nitrogen-phosphorus fertilizers. Methods. Research was carried out on chestnut heavy loamy soils. Sampling of soils and plants, as well as agrochemical properties of soils were determined according to standard generally accepted methods. Mathematical processing of data on the yield of cereals was carried out by analysis-of-variance method using computer technology. Results. Our studies showed that the most productive of the studied varieties was Grom, which, on average for three years (2012-2015) gave a grain yield of 7.6 t/ha with nitrogen-phosphorus fertilizers introduced at a dose of N180P100 against 5.6 t/ha in a similar version to the control during sowing of the Tanya variety. Vassa and Sila varieties were also inferior to Grom variety for yields, respectively, by 1.1 t/ha and 1.4 t / ha. It was also revealed that with the Grom variety, when applying an increased dose of mineral fertilizers (N180P100), on average for three years, the best indicators were by the area of the leaf surface (63.6 thousand m2/ha), photosynthetic index of crops was 2765.6 thousand m2/ha and net productivity of photosynthesis was 6.3 g/m2, day. For other varieties of winter wheat and doses of mineral fertilizers, these indicators were lower. Conclusion. In steady-state experiment, when studying the potential of new high-yielding varieties of winter wheat at different levels and times of introducing mineral nutrition, the Grom variety showed the best yields.