Opuntia species grow in arid and semiarid lands, where water for irrigation is scarce. However, supplemental irrigation can be a feasible strategy for commercial cactus pear orchards. From 2018 to 2020, a commercial cactus pear orchard was managed to validate the effect of supplemental irrigation on fruit yield, crop water use efficiency, fruit quality, and storability of ‘Roja Lisa’ cactus pear grown in the semiarid region of Mexico. The irrigation treatments were no irrigation and supplemental irrigation, with four replications. Crop water use was less and, therefore, water productivity greater in non-irrigated plants than in plants with supplemental irrigation. Mean fruit yield, mean fruit mass, and proportion of commercial fruit increased with supplemental irrigation. These differences were more pronounced in growing seasons with less rainfall. Fruit quality at harvest or after room temperature or cold storage was examined. Fruit mass loss rate was reduced in fruit receiving supplemental irrigation in both storage conditions. In addition, supplemental irrigation was consistent with water savings and food security programs in marginal areas: this irrigation strategy improved both pre- and postharvest some quality components of cactus pear fruit. Therefore, this irrigation strategy is suggested for cactus pear growers, depending on the availability of water for irrigation.