Water stands as a crucial component of agricultural production. This study aims to propose water efficiency measures in agriculture as an essential element for climate change adaptation. In this study, yield losses in staple crops in agricultural regions are analyzed by using the most suitable methodologies, particularly in agriculture-reliant developing nations. Furthermore, this study seeks to determine the financial consequences of such losses. The methodology applied for this purpose was implemented in Türkiye’s Iğdır Plain, selected as the study site. As the first step, the yields of the first three most cultivated products in each product group were assessed under normal climatic conditions in terms of their crop water requirements and irrigation water requirements. Subsequently, the irrigation water supply was reduced by 10%, and the resulting yield losses were calculated per hectare. Then, the overall crop losses after applying the 10% water constraint were determined in the total cultivation area. Among the crops cultivated in the region, the analysis reveals that clover from the field crops category exhibits the highest water dependence, while apricot demonstrates the least reliance on water resources. As a result, the recommended crop rotation for the Iğdır Plain under water constraints comprises wheat, apricot, watermelon, maize, melon, apple, tomato, peach, and clover. The following measures are proposed to ensure sustainable use of water resources and reduce exposure to climate change: increasing the water transmission efficiency and water use efficiency in irrigation areas, allocating more space to water-stress-resistant crops in the crop pattern in basins, and substituting crops requiring excessive water with less water-dependent crops.