Irregular Tumor Margin Research Articles

Osteossarcoma parosteal: aspectos na radiologia convencional

OBJETIVO: Avaliar os achados clínicos mais importantes do osteossarcoma parosteal e descrever os seus aspectos mais comuns na radiologia convencional. MATERIAIS E MÉTODOS: Estudo retrospectivo com 26 pacientes com osteossarcoma parosteal, provenientes do arquivo do Clube do Osso, Rio de Janeiro, RJ, e análise dos principais achados clínicos e aspectos radiológicos. RESULTADOS: A doença predominou em pacientes do sexo feminino e teve idade média de acometimento na terceira década de vida. Os achados clínicos mais freqüentes foram o aumento do volume no local do tumor (77% dos casos) e a dor local (68% dos casos). O local mais comum de tumor foi o oco poplíteo, com 40% dos casos, e houve envolvimento metafisário em 92% dos tumores. O aspecto radiológico mais comumente encontrado foi de lesão bem mineralizada e intimamente justaposta à superfície óssea, com o córtex adjacente irregularmente espessado (92,3% dos casos), observando-se área de adesão a este (88,5% dos casos), além de margens tumorais lobuladas (50% dos casos) ou irregulares (38,5% dos casos). Evidenciaram-se, também, linha radiolucente entre o tumor e o osso adjacente (48% dos casos), padrão de mineralização mais denso na base do que na periferia (42,3% dos casos) e pequena ocorrência de reação periosteal (15,4% dos casos). CONCLUSÃO: Apesar de a tomografia computadorizada e a ressonância magnética serem importantes na identificação de alguns aspectos do osteossarcoma parosteal, a radiologia convencional é altamente sugestiva deste tumor e permite, na maior parte dos casos, o diagnóstico diferencial com outras lesões da superfície óssea.

Impact of Computed Tomographic and Magnetic Resonance Imaging Findings on Surgical Outcome in Petroclival Meningiomas

The preoperative radiological findings of computed tomographic and magnetic resonance imaging scans of 70 patients with petroclival meningioma were evaluated and statistically compared with the degree of surgical resection and patients' outcomes to depict the most important radiological findings that may influence surgical radicality and outcome. The following parameters were evaluated: 1) tumor diameters; 2) tumor extension toward the middle fossa, the internal auditory canal, the brainstem, and the foramen magnum; 3) bone changes; 4) peritumoral edema; 5) signs of tumor infiltrative pattern; and 6) surgical radicality. Postoperative results were analyzed immediately after the surgery and in a long-term follow-up study. Larger tumors affected a younger population and presented a significantly shorter time until symptom onset. In the majority of cases (67%), the tumor extended to the parasellar region. Tumor extension toward the jugular foramen was found in 24% of the patients and reached the level of the foramen magnum in 18%. Irregular tumor margins were found in 67% of the tumors, and 50% of them presented peritumoral edema in addition. Interestingly, edema also was found in 20% of tumors with well-delineated margins. Tumor size, brainstem compression, and tumor extension laterally to the internal auditory canal did not influence either the degree of surgical resection or the long-term outcome (P > 0.05). Supratentorial tumor extension to the middle fossa and downward involving the caudal cranial nerves displayed a significant importance in regard to the surgical radicality and the patient's outcome, respectively (P < 0.05). Radiological evidence of infiltrative tumor pattern and peritumoral edema at the brainstem surface were important parameters regarding surgical radicality (P < 0.05). However, only peritumoral edema influenced the long-term results significantly.

Factors affecting the radiologic appearance of peripheral bronchogenic carcinomas.

The use of high-resolution computed tomography and magnetic resonance imaging have allowed the detailed description of morphologic findings associated with lung cancer. In particular, the desmoplastic response of lung tissue to tumor growth has not been adequately described. This article reviews roentgenologic and pathologic correlations of primary lung carcinomas. An irregular or indistinct tumor margin may be caused by tumor infiltration, an irregular desmoplastic response to the tumor growth, or irregular contraction in the central portion of the tumor. Solid tumor growth, on the other hand, may be associated with a well-defined tumor margin, with or without displacement of adjacent anatomical structures.

Computerized tomography scanning appearances of intracranial meningiomas. An attempt to predict the histological features.

✓ The computerized tomography (CT) scans of 102 patients with meningiomas confirmed at operation and histologically were reviewed, and the features displayed by the tumors were correlated with their histology. There were 54 transitional, 17 fibroblastic, 13 mixed transitional and fibroblastic, 10 angioblastic, and eight syncytial meningiomas. It was found that each of these meningioma variants exhibited common CT features that could be helpful in predicting the probable histology. These common features were: visible calcium aggregates, degree of surrounding edema, tumor density before and after contrast medium enhancement, homogeneity, and definition of outline. Visible calcium aggregates pointed to a diagnosis of either transitional or fibroblastic meningioma. None of the angioblastic or syncytial variants exhibited this feature. Most of the tumors were surrounded by edema of varying degrees (92%) but this was not considered to be a specific feature except perhaps in the fibroblastic type where the edema was almost invariably of moderate degree. Tumor attenuation values unenhanced by contrast medium were also nonspecific but in enhanced scans a homogeneous density distribution pointed to the tumor being most probably of the transitional type. The angioblastic and syncytial variants showed a marked tendency to exhibit low-density non-enhancing “cystic” areas or poorly defined, irregular tumor margins or fringes. All of the fibroblastic, transitional, or mixed fibroblastic and transitional variants were well defined with more or less regular shapes. The presence of marked edema, absence of visible calcium aggregates, non-homogeneous contrast enhancement with non-enhancing “cystic” components and poorly defined irregular borders point to aggressive or invasive characteristics more commonly found in the angioblastic and syncytial variants.