The paper presents a mathematical model for the deformation of soil under irregular cyclic loading in the simple-shear conditions. The model includes the possible change in the effective pressure in saturated soil due to the cyclic shearing, the reciprocal influence of the effective pressure on the response of the soil to the shear loading, and the pore pressure dissipation due to the seepage of the pore fluid. The hysteresis curves for the strain–stress relationship are constructed in such a way that they produce both the required backbone curve and the required damping ratio as functions of the strain amplitude. At the same time, the approach enables the constitutive functions involved in the model to be specified in various ways depending on the soil under study. The constitutive functions can be calibrated independently of each other from the conventional cyclic shear tests. The constitutive model is incorporated in the boundary value problem for the dynamic site response analysis of level ground. A numerical solution is presented for the dynamic deformation and liquefaction of soil at the Port Island site during the 1995 Hyogoken-Nambu earthquake.