Problem The ability of microorganisms to become resistant to the therapies used against them has long been recognized, and resistance rates for many isolates are rising rapidly. Although many factors contribute to resistance, it is strongly associated with the irrational use of antimicrobials themselves that additionally aggravates an existing microecological disbalance. All these lead to the increasing of persistent capabilities of cultivated germs. As a result, the vast number of inflammatory diseases of female internal genitalia tends to have primarily chronic course that significantly limits the necessity in antimicrobials' prescription. Objectives To contain the antimicrobial resistance for primarily adnexitis by establishing strong indications for antibiotics usage based on antilysozyme activity of strains cultivated. Methods 85 women aged 27–36 were examined to have primarily chronic adnexitis. The patients demonstrated inability to indicate both the approximate time and the reason of illness initiation. The complaints were mainly concentrated on continuous tenderness of adnexa region, wasting protracted course of disease (5–13 years), as well as ineffectiveness of numerous conventional antimicrobial therapies performed. Control group was presented with 20 women who hadn't had any lower urinary or genital tract inflammatory disorders within last year. Vaginal and endocervical samples were obtained, and both antibiotic susceptibility and antilysozyme activity of cultivated strains were examined. Conclusion The data obtained has shown the higher rates of antilysozyme activity of vaginal and endocervical floras that did not correlate with lowered antibiotic susceptibility in case group patients as compared with normal indices in controls. Thus persistent capabilities of microorganisms explain the ineffectiveness of antimicrobial therapy in primarily adnexitis, promote its spreading, quantitatively characterize the antimicrobial resistance, and may be used for its containment strategy.