Electron irradiations using a high voltage electron microscope were conducted on several reactor pressure vessel model alloys in order to investigate the effects of alloying elements on the formation and development of defect clusters. In addition, the effects of alloying elements on yield stress change after irradiation were considered, comparing the mean size and number density of dislocation loops with the irradiation-induced hardening. High Cu alloys formed Cu and Mn–Ni–Si rich clusters, and these are important in determining the yield stress increase. High Ni alloys formed a high density of small dislocation loops and probably Mn–Ni–Si rich cluster, which have the effect of increasing the yield stress. High P enhanced radiation-induced segregation on grain boundary, helping prevent dislocation movement.