Addition of nanoparticles currently in polymer blends has brought tremendous transformation in polymer engineering field. Incorporation of TiO2 nanofillers is believed to enhance the physical and mechanical properties of PVC/ENR blends due to its excellent characteristics including non-toxicity, long term stability and UV light discoloration resistance. The main objective of this research work is to introduce titanium dioxide (TiO2) nanofillers in a range of 0 - 6 phr into polyvinyl chloride (PVC) and epoxidized natural rubber (ENR) blends. Modification on mechanical properties of PVC/ENR blends has successfully been carried via irradiation crosslinking technique. The addition of TiO2 nanofillers has improved the tensile strength and hardness of the nanocomposites. Nevertheless, at higher loading of 6 phr, the results obviously showed an insignificant difference of performances for both tensile strength and shore hardness properties. Upon radiation of 50 kGy, the increase in Ts of the PVC/ENR blends with addition of 4 phr TiO2 was found to be optimum before the Ts value drops with higher exposure to irradiation dose rate. Gel fraction of irradiated PVC/ENR/TiO2 nanocomposites indicates the nanocomposites are crosslinked upon electron beam irradiation. Degree of crosslink was also increased with the addition of 4 phr and 6 phr TiO2.