Iron-folic Acid Research Articles

Functional integration of services during the antenatal period can potentially improve childhood growth parameters beyond infancy: findings from a post-interventional follow-up study in West Bengal, India

BackgroundDespite progress, the prevalence of childhood undernutrition in India remains amongst the highest globally.ObjectiveWe aimed to evaluate the impact of a functional integration interventional package during the antenatal period on childhood growth parameters.MethodsThis is a post-interventional follow-up study of a maternal nutrition interventional study conducted between 2018 and 2019 among women in their first trimester of pregnancy from three districts in West Bengal, India. Pregnant women received a package of augmented interventions from study staff which supplemented those provided to them under the state-run programmes, that included body-mass-index measurement at pregnancy registration, monthly weight monitoring, targeted dietary counselling, supervised supplementary nutrition intake and iron-folic acid supplementation during daily anganwadi center visits. In the current follow-up study conducted in 2021, age-matched pregnant women from the same areas who were pregnant during the same period as in the original study and had received standard-of-care under the state-run programmes were recruited into a comparison group. Study staff collected data regarding maternal height and serial weights that were recorded at antenatal visits in 2018-19, and birth and infant characteristics. Child height and weight were measured during the follow-up visit in 2021, which were used to calculate the relative risks of stunting, wasting and underweight using generalized linear models, to understand the sustained impact of the intervention beyond infancy. Eight-hundred-nine mother-child dyads (406 intervention; 403 comparison) were followed.ResultsMedian age of women in the intervention and comparison group was 23 (IQR 20–25) and 25 (IQR 24–27) years respectively. Median gestational-weight-gain was higher amongst intervention group women (9 vs. 8 kg, p = 0.04). Low-birth-weight prevalence was 29.3% (119/406) and 32.0% (129/403) in the intervention and comparison group. At 12–35 months of age, children born to women in the intervention group had significantly reduced risk of stunting (RR = 0.65, 95% CI 0.44–0.94), wasting (RR = 0.57, 95% CI 0.33–0.97) and underweight (RR = 0.61, 95% CI 0.42–0.88).ConclusionsThese results indicate that functional integration and strengthening of routine antenatal care services including targeted nutritional counselling to expectant mothers can have distal beneficial effects on childhood undernutrition beyond the immediate post-natal period.

Interpersonal Communication Strategies to Increase Iron-Folic Acid Supplement Consumption: Reduction in Anemia Through Normative Innovations (RANI) Project

More than half of women of reproductive age in India are anemic. This study investigates the role of interpersonal communication in increasing the consumption of iron-folic acid supplements. Interventions that increase interpersonal communication may influence and empower individuals and the larger community in promoting behavior change. This investigation uses data from a cluster randomized intervention to understand the pathways by which interpersonal communication mediates the consumption of iron-folic acid supplements. Longitudinal data from control and intervention arms in rural Odisha, India, were collected at baseline (N = 3,691) and 20 months later at end-line (N = 3,394). Structural equation models highlighted the positive role of interpersonal communication in mediating iron-folic acid supplement use. This study illustrates that even during social distancing due to COVID-19, strategic interpersonal communication can improve iron-folic acid supplement use. Our results elucidate two key interpersonal communication pathways at play, namely the ritualistic and instrumental pathways in improving health behavior change in the community.

Prevalence and Factors Associated with Adherence to Iron-Folic Acid Supplementation Among Pregnant Women in Eastern Sudan: A Cross-Sectional Study.

The present study was conducted to determine the prevalence and factors associated with adherence to iron-folic acid supplementation (IFAS) among pregnant women in eastern Sudan. A cross-sectional survey was conducted among pregnant women who obtained antenatal care (ANC) at Gadarif Maternal Hospital in eastern Sudan between May 1 and August 31, 2023. Face-to-face interview questionnaires were used to gather sociodemographic, obstetric, and clinical data (age, parity, education, residence, and previous medical diseases). Knowledge of anemia and IFAS was assessed. Multivariate analysis was performed to adjust for confounders. A total of 568 pregnant women were enrolled in the present study. Among them, 449 (79.0%) adhered to the IFAS. The multivariate analysis showed that the adjusted odds ratio (AOR) of IFAS adherence increased with ANC visits > 4 (AOR = 1.68, 95.0% CI = 1.01-2.77) and knowledge of anemia (AOR = 2.06, 95.0% CI = 1.437-3.276). In the univariate analysis, maternal occupation and knowledge of IFAS adherence were the only factors associated with IFAS adherence. Maternal age, parity, gestational age, education, residence, occupation, medical insurance, medical disease, and husband's occupation were not associated with IFAS. Forgetfulness (71.0%), frustration from taking many drugs (54.6%), and unpleasant tests of the supplement (50.7%) were the main reasons for not taking the IFAS. About four out of five pregnant women adhered to the IFAS, indicating a good level of adherence, especially among women who attended more than four ANC visits and those with good knowledge of anemia. More attention is needed to encourage ANC to increase adherence to IFAS.

Family Support for Maternal Health and Child Care during the First 1,000 Days of a Child's Life: An Exploration of the Experiences of Urban Families

This qualitative study examines the families' support regarding maternal health and child care toward mothers who demonstrated Good Compliance (GC) and Poor Compliance (PC) with nutrition interventions during the first 1,000 days of their child's life. The study employed an in-depth interview method to gather data from 20 fathers and 7 grandparents residing in Bogor City. The data were analyzed using a constant comparison approach between the GC and PC groups for each theme. The findings indicated that family members provided more specific support for child feeding than for maternal Iron-Folic Acid Supplementation (IFAS), given that the mothers encountered more difficulties on child feeding. Encouraging the mothers to continue taking IFA supplement despite their hesitance was predominantly reported by fathers in the GC fathers. Regarding child feeding, in addition to encouraging the child to eat and feeding them, the GC fathers often engaged in discussions with their wives. In contrast, the PC fathers rarely engaged in such discussions and were only consulted when their wives reported problem. Furthermore, fathers considered their wives to be more knowledgeable on these issues as fathers had limited time due to work commitment. Grandmothers primarily offered advice on child feeding based on their own experiences, sometimes providing less suitable advice for PC mothers. While fathers in both groups did not proactively seek information about maternal health and child care, the GC fathers were more likely to be encountered such information through discussions initiated by their wives, prompting them to pursue further reading. The interaction of fathers in both groups with health professionals only occurred during antenatal visits, with minimal communication. It is recommended that strategies be developed to engage family more highlight their crucial role in fostering a supportive environment for mothers. It is aslo advised that antenal visits be optimized and the Maternal and Child Health (MCH)handbook be utilized to raise awareness and enhance paternal involvement.

A cross-sectional study on factors associated with iron-folic acid supplement adherence among antenatal women of Haringhata block of Nadia district, West Bengal

Background: Anaemia, lack of can cause health complications across all age groups, particularly among pregnant women. In India, despite various governmental and non-governmental initiatives, the coverage and compliance of iron folic acid (IFA) therapy among pregnant women remain inadequate. This study aimed to estimate the prevalence of non-adherence and its determinants among pregnant mothers in Haringhata block, Nadia district, West Bengal. Methods: A community-based cross-sectional study was conducted, selecting eligible pregnant mothers through simple random sampling from sub-centre lists. Confidential interviews were conducted using a pre-designed, structured questionnaire, with informed consent obtained from participants. Data were entered in Microsoft excel and analyzed using statistical package for the social sciences (SPSS) 20.0. Results: Results showed that 37.7% of pregnant women were anaemic, and 19.9% were non-adherent to IFA supplements. Among the non-adherent, 56.5% missed IFA intake due to forgetfulness. Lack of knowledge was a significant barrier, with 53.42% unaware of IFA benefits and none knowing the exact duration of intake. Bivariate analyses indicated higher odds of non-adherence among mothers whose husbands were unemployed/unskilled, who suffered from anaemia, and who lacked knowledge about IFA benefits. Conclusions: The study findings suggest that addressing forgetfulness, providing accurate knowledge about IFA intake, and targeted interventions for teenage mothers can improve adherence rates, preventing anaemia and enhancing maternal and child health outcomes.

Assessment of knowledge and utilization of antenatal care services among tribal women of Palakkad district, Kerala: a cross-sectional study

Background: Nearly 800 women die out of preventable causes associated with pregnancy and childbirth worldwide every day, with low and middle-income countries contributing approximately 90% of the mortality. The majority of pregnancy-related deaths are preventable with the provisioning of cost-effective services like antenatal care (ANC). Despite Kerala having a good human development index compared to other states in India, marginalized groups like Dalit, Adivasi, and fisher folks are still behind the development process, including the utilization of ANC services. This study assessed the knowledge and utilization of ANC services among tribals in Kerala, India. Methods: A cross-sectional study was conducted among 45 tribal women of Palakkad district, Kerala, who registered for ANC and delivered child. Convenient sampling was used to select study participants. Descriptive statistics were used to obtain frequency and percentage. The chi-square test was carried out to see the association between identified variables. Results: Among 45 participants, 28.89% fell under the adequate ANC utilization. 64.46% did early ANC registration, 73.3% visited ANC more than four times, 75.56% completed the 2 tetanus toxoid (TT) injections, and 66.67% consumed more than 100 iron-folic acid tablets. About 73.3% of participants knew the importance of immunizing children against vaccine-preventable diseases. Conclusions: Even in an egalitarian state like Kerala with high literacy, ANC service utilization among tribal communities is still below 70%. The issue is multifaceted and requires a more nuanced approach. The health system must adopt comprehensive, context-specific, and community-based approaches.

Antenatal Diet Quality Modifies the Effect of Multiple Micronutrients (MMS) vs Iron-Folic Acid (IFA) on Risk of Low Birth Weight (LBW) in Bangladesh

Antenatal Diet Quality Modifies the Effect of Multiple Micronutrients (MMS) vs Iron-Folic Acid (IFA) on Risk of Low Birth Weight (LBW) in Bangladesh

Efficacy of Vidangadi lauha in the management of Pandu roga (~iron deficiency anemia) in adolescent girls

Introduction: Pandu roga can be correlated to Iron Deficiency Anemia (IDA) in the modern context. Adolescent girls are at high risk of IDA due to the high requirement of iron, low intake of nutrients, and blood loss during menses. Iron and folic acid are the drugs of choice for IDA, but it has some side effects such as stomach pain and constipation. Considering this, in the present study efficacy of Vidangadi lauha was compared with that of iron and folic acid as supplements. Materials and Methods: Adolescent girls aged 10–16 years were screened for the signs and symptoms of Pandu roga and those who were coming under the inclusion criteria for IDA were randomly arranged into two groups. The first group (Group A) was given 10 ml syrup of Vidangadi lauha once daily; while iron and folic acid tablets were given to the control group (Group B) as per the weekly iron-folic acid supplementation schedule for 3 months. For the assessment of therapy clinical features such as Panduta, Daurabalya, and Rukshata and hematological parameters were assessed before and after treatment. Results: On comparing Group A and Group B, the hematological parameters including hemoglobin show nonsignificant results. The difference in subjective parameters was also found statistically insignificant. Conclusion: Statistically, Vidangadi lauha and Iron and folic acid both showed improvement in hematological as well as clinical parameters. However, the formulation Vidangadi lauha is still preferred over iron and folic acid due to its holistic mode of action over Agni (~digestive and metabolic capacity) and the metabolic system of the body with no side effects.

Anaemia prevention among pregnant women: Views and experiences of pregnant women and antenatal care providers in Accra, Ghana

Background and ObjectiveAnaemia among pregnant women is a public health challenge in Ghana. Although there isa national programme of routine iron-folic acid (IFA) supplementation, coverage issuboptimal. The current study explored experiences and perceptions of anaemiaprevention, and IFA use among pregnant women and antenatal care providers at twohospitals in Accra, Ghana, for enhancing the supplementation programme.MethodsUtilizing a qualitative approach, 6 focus group discussions with 48 purposively selectedpregnant women, and 10 in-depth interviews with care providers in two hospitals wereconducted. Interviews were transcribed verbatim. Using both deductive and inductiveapproaches, priori themes that informed the design of the interview guides, and emergingcodes from transcripts were used in data analysis.ResultsIn both hospitals, pregnant women reported awareness of anaemia and identified poorquality diets and failure to take IFA as the predominant causes. Regular IFAsupplementation, and consumption of fruits, vegetables, and animal-source foods wereindicated as the main anaemia remedies by the pregnant women. Turkey berry, beetroot,and hibiscus flower were also reported as therapeutic remedies for anaemia. IFA use waslinked with improved appetite, haemoglobin, and health status of mothers and their fetus.Both providers and pregnant women indicated that IFA is freely accessible throughgovernment facilities but may also be purchased. IFA supplements are recommended to betaken daily but three times for treatment; however, non-adherence to the recommendedfrequency was reported. This was attributed to adverse reactions including nausea andvomiting, unanticipated cost of increased appetite, forgetfulness to take IFA,misperceptions about adverse effects of IFA, transportation cost to access IFA, and longwaiting time at hospitals. Community-level focused antenatal care, follow-up visits, andphone calls were reported by providers as strategies to improve IFA uptake. Communitysensitization, enhanced access to IFA, and participatory approach to ANC services weresuggested by pregnant women as strategies for improving IFA uptake.ConclusionsFood insecurity and misperceptions about IFA should be addressed as part of efforts toaddress low IFA adherence and high maternal and child anaemia rates in Ghana.

ЛЕЧЕНИЕ ЖЕЛЕЗОДЕФИЦИТНОЙ АНЕМИИ И ДЕФИЦИТА ФОЛАТОВ У ДЕТЕЙ РАННЕГО ВОЗРАСТА

Anemia is a global health problem worldwide associated with high morbidity and mortality rates and an increase in the number of hospitalizations. The article reflects the prevalence of grade 1 iron deficiency anemia and folate deficiency in children from 0 to 36 months of age, presents the latest data on the clinical efficacy of a drug containing iron protein succinylate and calcium folinate pentahydrate in this category of children in the treatment of grade 1 iron deficiency anemia and folate deficiency. The study monitored blood changes in children from 0 to 36 with grade 1 iron deficiency anemia and folate deficiency before and after treatment with a drug containing iron protein succinylate and calcium folinate pentagiomrate, and justified the pharmacoeconomical expediency of prescribing this drug from the point of view of the patient and the doctor.

Supports and Barriers Regarding The Iron-Folic Acid Supplementation Adherence Level in Anemic Pregnant Women: Indonesian’s Perspective

Supports and Barriers Regarding The Iron-Folic Acid Supplementation Adherence Level in Anemic Pregnant Women: Indonesian’s Perspective

The Effects of Maternal Iron and Folate Supplementation on Pregnancy and Infant Outcomes in Africa: A Systematic Review.

Iron and folate deficiency are prevalent in pregnant women in Africa. However, limited research exists on the differential effect of oral iron-only, folate-only, or Iron Folic Acid (IFA) supplementation on adverse pregnancy and infant outcomes. This systematic review addresses this gap, focusing on studies conducted in Africa with limited healthcare access. Understanding these differential effects could lead to more targeted and potentially cost-effective interventions to improve maternal and child health in these settings. A systematic review was conducted following PRISMA guidelines. The primary exposures were oral iron-only, folate-only, or IFA oral supplementation during pregnancy, while the outcomes were adverse pregnancy and infant outcomes. A qualitative synthesis guided by methods without meta-analysis was performed. Our qualitative synthesis analysed 10 articles reporting adverse pregnancy (adverse birth outcomes, stillbirths, and perinatal mortality) and infant outcomes (neonatal mortality). Consistently, iron-only supplementation demonstrated a reduction in perinatal death. However, evidence is insufficient to assess the relationship between iron-only and IFA supplementation with adverse birth outcomes, stillbirths, and neonatal mortality. Findings suggested that iron-only supplementation during pregnancy may reduce perinatal mortality in African women. However, evidence remains limited regarding the effectiveness of both iron-only and IFA supplementation in reducing stillbirths, and neonatal mortality. Moreover, additional primary studies are necessary to comprehend the effects of iron-only, folate-only, and IFA supplementation on pregnancy outcomes and infant health in the African region, considering rurality and income level as effect modifiers.

The prevalence of anemia during pregnancy and its correlates vary by trimester and hemoglobin assessment method in Eastern Maharashtra, India.

Approximately half of pregnant women in India are anemic, representing over 7.5 million women. Few studies have assessed the relationship between multiple micronutrient deficiencies and anemia during pregnancy or the trajectory of hemoglobin (Hb) during pregnancy in low-resource settings. We enrolled 200 pregnant women from the Maternal and Newborn Health (MNH) registry, a population-based pregnancy and birth registry in Eastern Maharashtra, India to address these gaps. The women provided capillary (finger-prick) and venous blood specimens at enrollment (<15 weeks), and a second capillary specimen in the 3rd trimester (>27 weeks). Capillary specimens were analyzed at the time of collection with a HemoCue Hb 201+; venous specimens were shipped on dry ice to a laboratory for cyanmethemoglobin assessment. In the 1st trimester, mean Hb concentration and anemia (Hb<11.0 g/dL) prevalence using capillary specimens were 10.9 ± 1.5 g/dL and 51.1%; mean Hb concentration using venous blood specimens was estimated to be 11.3 ± 1.3 g/dL and anemia prevalence was 37.5%. The prevalence of iron, vitamin B12 and folate deficiencies were 40%, 30% and 0%, respectively. Among women with anemia in the 1st trimester (venous blood), 56% had concurrent iron deficiency (inflammation-adjusted serum ferritin <15 µg/L) indicating that their anemia may be amenable to iron supplementation. In total, 21% of women had ID and anemia, 19% ID in the absence of anemia, 16.5% anemia in the absence of ID and 43.5% had neither. By the 3rd trimester, mean Hb from capillary specimens had declined to 10.1 ± 1.35 g/dL and anemia prevalence increased to 70.7%, despite 99.4% mothers reporting receipt of iron-folic acid (IFA) supplements during her current pregnancy, and 83.9% reporting IFA consumption the previous day. Significant predictors of anemia in the 1st trimester (both venous and capillary) included the number of weeks gestation at the time of Hb assessment and inflammation-adjusted serum ferritin. For 3rd trimester anemia, significant predictors included 1st trimester height, BMI and IFA consumption during the 3rd trimester (but not 1st trimester micronutrient biomarkers), indicating that IFA supplementation over the course of pregnancy may have influenced micronutrient status and anemia risk. Our findings highlight the severity of the burden of anemia and micronutrient deficiencies in Eastern Maharashtra, but also highlight that in many cases, ID and anemia affect different individuals. Preventing and managing anemia in pregnancy in India will require strengthening both clinical and community-based strategies targeting iron deficiency, as well as other causes of anemia.

Impact of weekly iron-folic acid supplementation on nutritional status and parasitic reinfection among school-age children and adolescents in Sub-Saharan Africa: a systematic review and meta-analysis.

Two significant etiological factors contributing to iron deficiency anemia, and undernutrition posing substantial public health challenges in Sub-Saharan Africa, are soil-transmitted helminths and malaria. This study carried out the effect of weekly iron-folic acid supplementation (WIFAS) on the nutrition and general health of school-age children and adolescents in Sub-Saharan Africa, a systematic review and meta-analysis have been conducted. To find pertinent publications for this study, a thorough search was carried out on May 20, 2023, across five databases: Pubmed (MEDLINE), Web of Science, Scopus, Cochrane Library, and Google Scholar. In addition, a search was conducted on August 23, 2023, to capture any new records. The inclusion criteria for the studies were based on school-age children and adolescent populations, randomized controlled trials, and investigations into the effects of WIFAS. The outcomes of interest were measured through anthropometric changes, malaria, and helminthic reinfection. A systematic review of 11 articles revealed that WIFAS significantly decreased the risk of schistosomiasis reinfection by 21% among adolescents (risk ratio = 0.79, 95%CI: 0.66, 0.97; heterogeneity I 2 = 0.00%, P = 0.02). However, no significant impact was observed on the risk of malaria reinfection (risk ratio = 1.02, 95%CI: 0.92, 1.13; heterogeneity I 2 = 0.00%, P = 0.67) or A. Lumbricoides reinfection (risk ratio = 0.95, 95%CI: 0.75, 1.19; heterogeneity I 2 = 0.00%, P = 0.65). Moreover, the analysis demonstrated that there is no significant effect of iron-folic acid supplementation in measured height and height for age Z-score (HAZ) of the school-age children (Hedge's g -0.05, 95%CI: -0.3, 0.2; test for heterogeneity I 2 = 0.00%, P = 0.7) and (Hedge's g 0.12, 95%CI: -0.13, 0.37; test for heterogeneity I 2 = 0.00%, P = 0.36) respectively. The effectiveness of WIFAS in reducing the risk of schistosomiasis reinfection in adolescents has been demonstrated to be greater than that of a placebo or no intervention. Additionally, the narrative synthesis of iron-folic acid supplementation has emerged as a potential public health intervention for promoting weight change. However, there was no significant association between WIFAS and Ascariasis, trichuriasis, and hookworm. Moreover, the certainty of the evidence for the effects of WIFAS on height and malaria is low and therefore inconclusive. Whereas, the certainty of the evidence for the effectiveness of WIFAS on Schistosomiasis is moderate. Even though the mechanisms need further research WIFAS may be implemented as part of a comprehensive public health strategy to address schistosomiasis in adolescents. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023397898, PROSPERO (CRD42023397898).

Compliance level and associated factors of iron folic acid supplementation among pregnant women in North Shoa Zone, Ethiopia

Iron deficiency is a widespread micronutrient deficiency, impacting over 30% of the global population. Iron Folic Acid supplement is recommended for pregnant women to counter iron deficiency anemia and neural tube anomalies. Although Iron Folic Acid supplementation is integral to Ethiopian antenatal care, one in four women in Ethiopia experiences anemia during pregnancy suggesting poor compliance. This study aimed to investigate compliance level and associated factors of Iron Folic Acid supplementation among pregnant women attending antenatal care in Wuchale Woreda of North Shoa Zone, Ethiopia. An institutional-based cross-sectional study was conducted among 302 pregnant women from March 20 to April 5, 2021, who were selected using a systematic random sampling technique. Data were collected through face-to-face interview, entered epi-data, and exported to Statistical Package for the Social Sciences for analysis. A multivariable logistic regression was used to identify factors associated with compliance level. All the results were presented with 95% confidence intervals. The compliance with Iron Folic Acid supplementation was 47.0%. Residing nearest to the health facility (AOR = 2.46; 95% CI 1.32, 4.57), initiating antenatal care at health center (AOR = 2.23; 95% CI 1.17, 4.51), having a family size of 4 and above (AOR = 4.99; 95% CI 2.43, 10.24), and receiving information from health extension workers (AOR = 5.52; 95% CI 1.30, 23.54) increased compliance with Iron Folic Acid supplementation. Less than half of the pregnant women were compliant with Iron Folic Acid utilization. There is a need to prioritize promoting the importance of Iron Folic Acid supplementation through health education particularly by targeting pregnant women with identified factors.

Adherence to weekly iron folic acid supplementation and associated factors among adolescent girls – A mixed-method study

ABSTRACT Context: Despite the Weekly Iron folic acid supplementation (WIFS) program, the prevalence of anaemia among adolescent girls remains high. Phase 1 Indian Council of Medical Research (ICMR) task force study conducted in 2016 in Kallur showed that the IFA provision rate for adolescent girls was 72% but the consumption rate was only 15% in the Kallur area. The present study was done to identify the gaps for the difference between provision and consumption rate of weekly IFA tablets among adolescent girls using the WHO conceptual framework in home-based settings. Materials and Methods: This crosssectional study with a mixedmethod design was conducted from October 2020 to December 2021. Quantitative data were collected from 972 adolescent girls and their parents using a structured pretested questionnaire, whereas qualitative exploration was done by focus group discussions. Descriptive analysis and bivariate analysis were used to analyse the quantitative data. Qualitative data were analysed and integrated with quantitative results. Results: The overall number of girls who were aware of Iron Folic acid therapy (IFAT) was 704 (72%). However, only 132 (13%) adolescent girls were found to be adherent to IFA therapy. Multivariable regression analysis revealed that side effects encountered on intake of IFAT (Odds ratio (OR) =0.5, P = 0.009) were associated with higher rates of nonadherence, whereas regular supply (OR = 13.6, P = 0.000), health education to parents (OR = 2.76, P = 0.002), and experiencing benefits (OR = 1.72, P = 0.006) were associated with higher rates of adherence. These were substantiated by qualitative findings. Conclusions: Ignorance on the impact of anaemia on adolescent health, fear of side effects, unpleasant effects experienced on intake of Iron folic acid (IFA), and inadequate counselling determines the adherence to weekly IFA supplements among adolescent girls.

Weekly iron-folic acid supplementation and its impact on children and adolescents iron status, mental health and school performance: a systematic review and meta-analysis in sub-Saharan Africa

ObjectiveThis systematic review and meta-analysis aimed to comprehensively assess the impact of weekly iron-folic acid supplementation (WIFAS) on the nutrition, health and educational outcomes of children and adolescents in sub-Saharan...

Assessment of iron, folic acid, and vitamin B12 deficiencies and their association with red cell indices in anemic and non-anemic women

During pregnancy anemia is a common health issue with various factors influencing its occurrence. It is a major public health problem in India. It is believed that 2.36 billion individuals are affected globally, and it is also an endemic problem in India. Iron deficiency often leads to iron deficiency anemia (IDA), significantly influencing maternal and fetal health.This study aims to investigate the complete blood count and nutritional parameters including Iron profile, vitamin B12, and Folic acid in anemic and non-anemic participants.The study involved 458 women of which 300 were anemic women and 158 were non-anemic women, predominantly from rural areas. The severity of anemia was classified as per WHO guidelines. The CBC was estimated by a 3-part hematology analyzer Medonic M-series, while the iron profile, vitamin B12, and folic acid were measured by using an automated analyzer Abbott Architect 1000 SR.The severity of anemia among the anemic women, classified according to WHO guidelines, revealed that 38.7% had mild anemia, 32.7% had moderate anemia, and 28.6% had severe anemia. 39.3% women exhibited microcytic hypochromic cells, 38% had normocytic normochromic cells, and 22.7% exhibited macrocytic cells. 56.6% had iron deficiency, 10% had folate deficiency, 16.7% had vitamin B12 deficiency, 6.7% had iron+vitamin B12+folic acid deficiency and 10% had vitamin B12+folic acid deficiency. Based on the severity only vitamin B12 was significantly reduced in severe (145.65±58.43) than moderate (177.06±66.24) and mild group (174.43±68.43), p=0.042. Hemoglobin showed a positive correlation with iron level (r=0.523, p&amp;#60;0.0001), and a negative correlation with ferritin (r=-0.355, p&amp;#60;0.0001).: These findings provide valuable insights into the nutritional status of the anemic women and highlights the need for targeted interventions to address micronutrient deficiencies during pregnancy.

Low Vitamin A Status: A Potential Limiting Factor for Hemoglobin Improvement to Iron–Folic Acid Supplementation in Adolescent Girls with Iron Deficiency Anemia

Low Vitamin A Status: A Potential Limiting Factor for Hemoglobin Improvement to Iron–Folic Acid Supplementation in Adolescent Girls with Iron Deficiency Anemia

Dietary micronutrients intake and its effect on haemoglobin levels of pregnant women for clinic visit in the Mount Cameroon health area: a cross-sectional study.

Nutritional deficiencies and its consequences such as anaemia are frequent among pregnant women residing in under resource settings. Hence, this study sought to investigate specific dietary micronutrient inadequacy and its effect on maternal haemoglobin levels. This institution based cross-sectional survey enrolled 1,014 consenting pregnant women consecutively. Data on socio-demographic, economic and antenatal characteristics were recorded using a structured questionnaire. Minimum dietary diversity for women (MDD-W) was assessed using the 24-h recall method and haemoglobin (Hb) concentration (g/dL) determined using a portable Hb metre. Significant levels between associations was set at p < 0.05. Among those enrolled, 40.9% were anaemic while 89.6% had inadequate dietary nutrient intake. In addition, uptake of blood supplements, haem iron, plant and animal-based foods rich in vitamin A were 71.5, 86.2, 35.5 and 12.6%, respectively. Moreover, anaemia prevalence was significantly (p < 0.05) lower in women who took iron-folic acid along with food groups rich in haem iron (38.5%) or both plant and animal vitamin A (29.0%). Besides, mean maternal Hb levels was significantly (p < 0.001) higher in women who consumed haem iron (11.08 ± 1.35) and vitamin A food groups (11.34 ± 1.30) when compared with their counterparts who did not consume haem iron (10.54 ± 1.19) and vitamin A food groups (10.74 ± 1.31). Dietary uptake of foods rich in haem-iron and vitamin A significantly improves Hb levels in Cameroonian pregnant women. Our findings underscore the importance of improving maternal nutritional awareness and counselling during antenatal period to reduce the anaemia burden.