The paper deals with the play, written by the Czech writer Karel Čapek «The Makropulos Affair». The play is analyzed in the context of philosophical search of the time of its emergence. Particularly, I. I. Mechnikov’s essays concerning longevity and accompanying it the sense of life matters are observed in the paper. Also, the author makes the comparative analysis of the ideas, represented by the K. Čapek’s play and by the Irish dramatist George Bernard Shaw’s theatrical work «Back to Methuselah», in which the ideas of longevity and the sense of life were raised. These works were published almost simultaneously, and both authors were influenced by Mechnikovs’ views. The points of contact and differences in authors’ positions are observed. The paper represents modi of actualization of longevity and the sense of life issues in the contemporary culture by the examples of the musical «The Recipe of her Youth» and the case study from the Julian Baggini’s popular philosophy guide «The Pig that Want to Be Eaten». We can agree with the Baggini’s idea that the sense of life is not defined by the numbers of years, but by their fullness with contents and the desire to use them in full.