Transference Number Research Articles

Inter-organizational pooling of NICU nurses in the Dutch neonatal network: a simulation-optimization study.

Neonatology care, the care for premature and severely ill babies, is increasingly confronted with capacity challenges. The entire perinatal care chain, including the Neonatal Intensive Care Unit (NICU), operates at high occupation levels. This results in refusals, leading to undesirable transports to other centers or even abroad, which affects quality of care, length of stay, and safety of these babies, and places a heavy burden on patients, their families, and involved caregivers. In this work we assess the improvement potential of network collaboration strategies that focus on reducing the number of patient transports, by allowing flexible deployment of nurses over the existing NICUs to match short-term changes in patient demand. We develop a discrete event simulation with an integrated optimization module for shift allocation and transfer optimization. A case study for the Dutch national NICU network, involving 9 NICU locations and current transport of 15% of all NICU patients in case of no flexible deployment, shows the potential of transporting staff instead of patients: About 70% of patient transports can be eliminated in case of 15-50% capacity sharing, and about 35% of nationwide transports is eliminated with up to 15% capacity sharing in the Dutch's main conurbation area only.

Hopping-Phase Ion Bridge Enables Fast Li+ Transport in Functional Garnet-Type Solid-State Battery at Room Temperature.

Composite polymer electrolytes (CPEs) containing Li6.4La3Zr1.4Ta0.6O12 (LLZTO) is widely regarded as leading candidate for high energy density solid-state lithium-metal batteries due to its exceptional ionic conductivity and environmental stability. However, Li2CO3 and LiOH layers at LLZTO surface greatly hinder Li+ transport between LLZTO-polymer and the electrode-electrolyte interface. Herein, the surface of LLZTO is boronized to obtain functionalized LLZTO, and its conversion mechanism is clarified. By dissolving the crystal structure of cellulose to obtain hopping-phase ion bridge (HPIB), which release the Li+ transport activity of its oxygen-containing polar functional group (─OH, ─O─). Therefore, a high-throughput ion transporter (HTIT-37) with high ion transfer number (0.86) is prepared by introducing the HPIB into functionalized LLZTO and polyvinylidene fluoride interface by intermolecular hydrogen bond interaction, and it is demonstrated that the HPIB acts as a "highway" for the Li+ across this heterogeneous interface. Moreover, the HPIB is found to self-adsorb on the SEI surface, leading to fast Li+ transport kinetics at anode-CPE interface. Thus, the lifespan of Li|HTIT-37|Li is over 8000 h, and the critical current density exceeds 2.3 mA cm-2. The LiNi0.5Co0.2Mn0.3O2|Li and Li1.2Ni0.13Co0.13Mn0.54O2|Li battery remains stable with the HPIB-enhanced electrode process, proving the application potential of LLZTO-based CPE in high energy density SSLMB.

Compatible Interfaces Constructed by Surficial Indiumization on Garnet Solid Electrolyte for Long-Cycling All-Solid-State Lithium Metal Battery.

Composite solid electrolytes (CSEs) based on poly(vinylidene fluoride)-co-hexafluoropropylene (PVDF-HFP) and Li6.4La3Zr1.4Ta0.6O12 (LLZTO) show great potential in building high energy density all-solid-state lithium metal batteries (ASSBs). Nevertheless, the Li2CO3 passivation layer formed on the LLZTO surface not only induces dehydrofluorination of PVDF-HFPbut also blocks Li+ transport at the interfaces of PVDF-HFP/LLZTO and CSE/electrodes. Herein, lithium acetate-assisted surficial indiumization with a thickness of 4nm is carried out to convert the detrimental Li2CO3 into a stable Li+ conductor of LiInO2 (LIO) on LLZTO. With this modification, high air stability of CSEs is achieved which prevents Li2CO3 regeneration and PVDF-HFP dehydrofluorination effectively. Attributed to the unblocked Li+ transport paths at the LLZTO@LIO/PVDF-HFP (LIO-CSE) interface, high ionic conductivity of 3.1×10-4 S cm-1 and the Li+ transference number of 0.673 are attained. The Li2CO3-free LLZTO also contributes to constructing robust solid electrolyte interphase with predominantly inorganic components, which successfully decreases the side reactions and ultimately realizes good compatibility at the LLZTO/polymer and electrolyte/electrode interfaces. The assembled Li|LIO-CSE|Li cells exhibit excellent electrochemical stability for 3100h at 0.5mA cm-2. The Li/LIO-CSE/LiFePO4 ASSB delivers high-capacity retention of 81.8% after 1000 cycles at 25 °C. This work provides a promising method toward remarkable interfacial compatibility for ASSBs.

In Situ Coordinated MOF-Polymer Composite Electrolyte for Solid-State Lithium Metal Batteries with Exceptional High-Rate Performance.

The integration of metal organic frameworks (MOFs) and electrospun polymer fibers offers the potential to achieve uniform dispersion and high loading of fillers, providing a unique perspective for advancing composite solid electrolytes in solid-state lithium metal batteries. In this work, a composite solid electrolyte is fabricated through a combination of electrospinning and chemical immersion, facilitating the in situ nucleation and growth of HKUST-1 on polyacrylonitrile (PAN) electrospun nanofibers. The in situ coordinated HKUST-1 particles not only modify the solvation structure of Li+ and the coordination environment of TFSI-, but also encapsulate PAN fibers to mitigate interfacial side reactions with lithium metal, thereby improving interfacial stability. Consequently, the solid-state electrolyte achieves a high Li ion transference number of 0.77 and an impressive critical current density of 4.5 mA cm-2. The assembled Li||Li symmetric cell exhibits stable operation for over 4000 h at 4.0 mA cm-2, while Li||LFP and Li||NCM811 cells demonstrate exceptional rate capability and cycling stability. This work provides valuable insights into the design and fabrication of MOF/polymer-based composite solid electrolytes.

Elucidation of Li+ Conduction Behavior in MOF Glass Electrolyte Toward Long‐Cycling and High C‐Rate Lithium Metal Batteries

AbstractVitrified metal–organic frameworks (MOFs) are promising solid‐state electrolytes for lithium metal batteries due to their unique structures. Nevertheless, the effect of distorted molecular structures in glassy MOFs on Li+ migration behavior at the molecular level remains largely unexplored, posing a huge obstacle to further boosting their electrochemical performances. Herein, Li+ conduction behavior in glassy ZIF‐62 quasi‐solid‐state electrolyte (GZ‐62‐QSSE) is molecularly elucidated, in which Li+ migration is accomplished by the continuous delivery of N sites in imidazole and benzimidazole ligands like the process of relay race. Such fast Li+ migration in GZ‐62‐QSSE demonstrates more than 1.5‐time increase in transference number and helps to generate inorganic‐dominated cathode/anode interphases for unblocked ion transport compared with crystalline ZIF‐62 electrolyte. Consequently, the long‐term stability with remarkable high‐rate capability is realized in the proof‐of‐the‐concept full cells, which represents one of best values among all reported MOF‐based solid‐state batteries. For example, LiFePO4 ||Li full cells employing GZ‐62‐QSSE brilliantly undergo 3000 cycles with high initial capacity of 132.1 mAh g−1 and ultralow decay rate of 0.009% at 1 C. Full cells still display high discharge capacity of 83.6 mAh g−1 at 5 C. The elaborated high‐performance glassy ZIF‐62 electrolyte offers new insights for exploiting advanced solid‐state electrolytes and propels the development of solid‐state lithium metal batteries.

Engineering Carboxyl Content in Aqueous Core-Shell Emulsions for Efficient Inorganic Coated Separators Enhancing Lithium-Ion Battery Safety Performance.

Polypropylene separators (PP) are widely used in lithium-ion batteries due to good electrochemical stability and low cost. However, PP separators are prone to thermal shrinkage at high temperatures, resulting in short circuit of positive and negative electrode contacts and thermal runaway. In this work, a waterborne core-shell emulsion binder rich in carboxyl and ester groups with both strength and adhesion is designed and coated with alumina (Al2O3) as a composite coating on the PP separator. Due to the good adhesion of the emulsion binder to the Al2O3 and the PP separator, the separator has excellent dimensional stability at 120 °C, while the thickness of the separator only increases by 2.5 μm. With the help of the dissociation effect of the ester group on the lithium salt and the lithium ion conduction characteristics, the composite separator improves the ionic conductivity (0.82 mS/cm) by 25 % compared with the PP separator and the lithium ion transference number reaches 0.47. The cycling capacity of the lithium-ion battery with the composite separator is 8.62% higher than that of the PP separator after 100 cycles. The performance changes of acrylic acid as a functional monomer on emulsion binders and composite separators are further investigated.

Enhancing structural, thermal, and electrical properties of plasticized lithium-based PVdF-HFP polymer electrolytes for flexible energy storage applications

Lithium ion-conducting plasticized polymer electrolyte membranes were prepared using poly (vinylidene fluoride-co-hexafluoropropylene) (PVdF-HFP) as the host polymer, lithium triflate (LiTf) as the dopant salt, and ethylene carbonate (EC) as the plasticizer, with varying compositions accomplished using the solution casting technique. X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and differential scanning calorimetry (DSC) analyses validate the presence of substantial structural alterations and the formation of a complex in the plasticized polymer electrolytes. The electrochemical impedance spectroscopy (EIS) analysis demonstrates an increase in ionic conductivity by about two orders of magnitude after the addition of EC. Estimates of ionic transference numbers derived from the direct current (DC) polarization approach indicate that charge transport in plasticized polymer electrolytes is mostly ionic. We examined the discharge characteristics of our flexible electrochemical storage device (FESD) over 25 h. The mean discharge current is 1.4 mA with a 0.04 C rating.

Regulating Interfacial Chemistry to Boost Ionic Transport and Interface Stability of Composite Solid‐State Electrolytes for High‐Performance Solid‐State Lithium Metal Batteries

AbstractComposite solid‐state electrolytes (CSSEs) that combine the benefits of inorganic and polymer electrolytes hold great potential for solid‐state lithium metal batteries (SSLMBs) due to their high ionic conductivity and superior mechanical properties. However, their overall performance is severely hindered by several practical challenges, including inorganic component aggregation, poor interface behavior, and limited Li+ transport. Here, a unique ultrathin coating of triaminopropyl triethoxysilane with a bifunctional structure is introduced that effectively bridges the inorganic fillers (Li1+xAlxTi2‐x(PO4)3, LATP) and the polyvinylidene fluoride hexafluoropropylene /polyethylene oxide polymer matrix, thereby enabling high‐performance CSSEs (referred to as SLPH). This design prevents LATP particle agglomeration, improves interfacial compatibility, and ensures the enrichment and fast transport of Li+ within SLPH. Consequently, the SLPH exhibits a low ionic conduction energy barrier (Ea = 0.462 eV), desirable ionic conductivity (4.19 × 10−4 S cm−1 at 60 °C), and a high Li+ transference number ( = 0.694). As a result, SSLMBs with SLPH, including Li| SLPH |Li symmetric cells, LiFePO4| SLPH |Li coin‐type, and pouch cells, demonstrate superior rate capability and long‐time cycling stability. This work underscores the significance of surface functionalization of inorganic electrolytes to create a stable solid‐solid interface and enhance ionic conduction, paving the way for high‐performance CSSEs in SSLMBs.

Polyimide/cellulose composite membrane with excellent heat-resistance and fast lithium-ion transport for lithium-ion batteries.

Polyimide membranes have long been of great interest in the battery industries due to their outstanding thermal stability and flame retardancy. However, the preparation of polyimide membranes with ideal pore structure and excellent lithium-ion transference remains a challenge. In this study, we reported for the first time, that a nano-porous fluorinated and partially carboxylated polyimide/cellulose composite membrane was successfully synthesized by selected monomers and prepared by thermal imidization, phase separation, and alkaline hydrolysis method. Particularly, an appropriate addition of cellulose acetate (CA) during the synthesis process can optimize the pore structure of the membrane. Besides, CA was converted to cellulose after alkaline hydrolysis, further enhancing the electrolyte affinity and lithium-ion transference of the membrane. Hence, this composite membrane exhibited distinct heat-resistance, high porosity (78 %), electrolyte absorption (344 %), and lithium-ion transfer number (0.84). Most importantly, thanks to the above characteristics of the membrane, the assembled LiFePO4/Li cells demonstrated excellent cycling stability compared with the cell with PP membrane, showing a capacity retention rate of as high as 93 % after 500 cycles at 1C. We anticipate that this composite membrane with superior physical and electrochemical properties would shed light on the development of next-generation membranes for high-power and high-safety batteries.

Modeling of effective cationic transference number in soft matter battery electrolytes based on conservative ensemble theory

Modeling of effective cationic transference number in soft matter battery electrolytes based on conservative ensemble theory

Nanocrystals with Aggregate Anionic Structure Enable Ion Transport Decoupling of Chain Segment Movement in Poly(ethylene oxide) Electrolytes

All‐solid‐state polymer electrolytes are promising for lithium batteries, but Li+ transport in these electrolytes relies on amorphous chain segment movement, leading to low Li+ mobility and poor mechanical strength. Here we propose a novel Li+ transport mechanism mediated by PEO3:LiBF4 nanocrystals (NCPB) with the aggregate (AGG) anionic structure, which enables a change from amorphous to crystalline phase dominated ion transport in all‐solid‐state PEO/LiBF4 electrolyte. Experiments and simulations reveal that the interaction between Li+ and F in NCPB with AGG anionic structure simultaneously restricts anion transport and reorients anions within the free volume of NCPB, resulting in a three‐coordination intermediate to facilitate Li+ transport. The unique Li+ transport mechanism through NCPB makes the PEO/LiBF4 electrolyte with a high Li+ transference number (0.73) and remarkably increased mechanical strength (Young's modulus > 100 MPa) at 45 °C. As a result, the Li|LiFePO4 batteries with the ultrathin self‐supported PEO/LiBF4 electrolyte (10 μm) exhibit significantly improved cycle life (92% @ 500 cycles) compared to those with PEO/LiTFSI electrolyte (failed @ 68 cycles). This work demonstrates a novel ion transport mechanism for achieving selective and rapid Li+ transport.

Nanocrystals with Aggregate Anionic Structure Enable Ion Transport Decoupling of Chain Segment Movement in Poly(ethylene oxide) Electrolytes.

All-solid-state polymer electrolytes are promising for lithium batteries, but Li+ transport in these electrolytes relies on amorphous chain segment movement, leading to low Li+ mobility and poor mechanical strength. Here we propose a novel Li+ transport mechanism mediated by PEO3:LiBF4 nanocrystals (NCPB) with the aggregate (AGG) anionic structure, which enables a change from amorphous to crystalline phase dominated ion transport in all-solid-state PEO/LiBF4 electrolyte. Experiments and simulations reveal that the interaction between Li+ and F in NCPB with AGG anionic structure simultaneously restricts anion transport and reorients anions within the free volume of NCPB, resulting in a three-coordination intermediate to facilitate Li+ transport. The unique Li+ transport mechanism through NCPB makes the PEO/LiBF4 electrolyte with a high Li+ transference number (0.73) and remarkably increased mechanical strength (storage modulus >100 MPa) at 45 °C. As a result, the Li|LiFePO4 batteries with the ultrathin self-supported PEO/LiBF4 electrolyte (10 μm) exhibit significantly improved cycle life (97 % @ 468 cycles) compared to those with PEO/LiTFSI electrolyte (failed @ 68 cycles). This work demonstrates a novel ion transport mechanism for achieving selective and rapid Li+ transport.

Lessons learned on obtaining reliable dynamic properties for ionic liquids.

Ionic liquids are nowadays investigated with respect to their use as electrolytes for high-performance energy storage materials. In this study, we provide a tutorial on how to calculate dynamic properties such as self-diffusion coefficients, ionic conductivities, transference numbers, as well as ion pair and ion cage dynamics, that all play a role in judging the applicability of ionic liquids as electrolytes. For the case of the ionic liquid \ce{[C2C1Im][NTf2]}, we investigate the performance of different force fields. Amongst them are non-polarizable models employing unity charges, a charge-scaled version of a non-polarizable model, a polarizable model and another non-polarizable model with refined Lennard-Jones parameters. We also study the influence of the system size on the dynamic properties. While all studied force field models capture qualitatively correct trends, only the polarizable force field and the non-polarizable force field with refined Lennard-Jones parameters provide quantitative agreement to reference data, making the latter model very attractive for the reason of lower computational costs.

Inhibiting Interfacial Electron Leakage via An Artificial Rectified Layer for Longevous Zinc Metal Anodes.

Dendrites and water-induced side reactions impose greatly challenge on the implementation of aqueous zinc ion batteries. To tackle these problems, an artificial rectified layer (ARL) with hydrophobic, zincophilic and insulating features was in-situ synthesized on Zn surface rapidly to prevent the electron leakage from Zn anode to aqueous electrolyte, which is the underlying logic for uneven Zn deposition and parasitic side reactions. The ARL also displays a high Zn2+ transference number of 0.71 and can build fast Zn2+ transport channels to homogenize the interfacial ion flux and electric field according to the calculated work function and multi-physics phase simulation results. Therefore, the Zn anode with ARL shows preferred plating along with (002) crystal facet and an admirable Coulombic efficiency of 99.86% over 3200 cycles. Zn symmetric cells can withstand large current density up to 40 mA cm-2 and operate stably at 44.2% depth of discharge for 250 hours, surpassing most of published reports. The ARL also enables the Zn||MnO2 full batteries to circulate over 2600 cycles with a high-capacity retention of 80.1% and low self-discharge at 1 A g-1. This work provides a different perspective to comprehend and design satisfactory solid electrolyte interphase for Zn metal anodes.

Multiscale Collaborative Optimization for Composite Solid Electrolyte to Achieve High-Performance Lithium Metal Batteries.

Composite solid electrolytes (CSEs) possess significant advantages over individual polymer or inorganic solid electrolytes. However, conventional CSEs suffer from multiple scale issues, including interruptions in ionic transport pathways, incompatibility at heterogeneous interface, and the excessive thickness of electrolytes. Herein, a novel CSE with ultrathin structure (22 µm) based on the strategy of multiscale collaborative optimization (MC-CSE) is designed. This strategy involves continuous, rapid, and homogeneous Li+ transport from macroscale to microscale. i) The bicontinuous structure of MC-CSE is constructed via in situ polymerization of 1,3-dioxolane in a continuous yet porous Li6.4La3Zr1.4Ta0.6O12 (CP-LLZTO) skeleton, which effectively reduces the barrier for Li⁺ transport at macroscale. ii) The continuous interconnected CP-LLZTO and poly 1,3-dioxolane (PDOL) phases within MC-CSE ensures continuous Li+ transport at mesoscale. iii) CP-LLZTO and PDOL synergistic interaction at heterogeneous interface, which facilitates the rapid and homogeneous Li+ transport at microscale. Consequently, the MC-CSE shows both high ionic conductivity and Li⁺ transference number (1.04 mS cm-1 and 0.87). The cells assembled with MC-CSE exhibit outstanding low-temperature (-20°C) and high-voltage (4.5 V) performance. The strategy of multiscale collaborative optimization provides a promising perspective for the viability of lithium metal batteries at various conditions.

P-1432. Assessing Equitable Access to Carbapenemase Production Testing in Los Angeles County Hospitals

Abstract Background Carbapenemase producing organisms (CPO) are the cause of difficult-to-treat infections that result in substantial morbidity and mortality. Due to this and because CPOs can spread quickly between patients, hospital microbiology laboratories should be incentivized to test for carbapenemase production (CP), yet testing costs have stifled uptake. In Los Angeles County (LAC), laboratory professional organizations and the LAC Department of Public Health have broadly promoted CP testing, without emphasis on hospitals that accept patients of highest risk of acquiring a CPO, including patients with a history of long-term care. This analysis assesses CP testing uptake in LAC hospitals and association with patient population and social vulnerability. Methods CP testing in hospitals was assessed using the 2022 National Healthcare Safety Network Annual Facility Survey. We assessed patient origin from the Centers for Medicare and Medicaid Services claims and Minimum Data Set and patient characteristics from the California Department of Health Care Access and Information Healthcare Utilization. Frequencies, logistic regression, and Fisher’s exact tests were performed to evaluate the relationship between CP testing and hospital patient and facility-level characteristics. Results Of the 79 surveyed hospitals in LAC, 51 (65%) tested for CP. No significant relationship was identified between access to CP testing and the number of patient transfers from high-risk facilities (OR=1.00 , 95% CI [1.00, 1.00]), area poverty (OR=1.01 , 95% CI [0.95, 1.07]), the percent of patients with Medicaid or Medicare (OR=0.94 , 95% CI [0.91, 0.98]), the percent of non-white patients (OR=1.01 , 95% CI (0.99, 1.03]), and hospital ownership (p=0.66). Conclusion Access to CP testing was lower among hospitals serving more patients with public insurance and did not differ based on number of high-risk patients. This analysis is limited in that testing capacity was assessed, but data were not available on frequency of testing or implementation of a process to test at-risk individuals. Testing performed at the LAC Public Health Laboratory can supplement testing gaps for facilities of high need. More outreach to hospitals serving highest risk patients to support access to CP testing is needed. Disclosures All Authors: No reported disclosures

‘The Moroccan king wants Western Sahara without its people’: an argument for Western Sahara as a settler colony

ABSTRACT This paper examines the case of Western Sahara through the lens of settler colonial studies. A former Spanish colony in northern Africa, Western Sahara is most often described as ‘occupied’ by Morocco since 1975. I aim at shifting this narrative by applying settler colonial theory, more specifically Veracini’s concept of transfer, to the relation between Moroccan authorities and the indigenous population. Building on anthropological fieldwork in Sahrawi refugee camps in Algeria and interviews with Sahrawis in Algeria, Morocco and Europe, I look at how Sahrawis have experienced a number of transfers whose compounded effect is the gradual elimination of the native population.

Towards Solid‐State Batteries Using a Calcium Hydridoborate Electrolyte

Solid‐state batteries created from abundant elements, such as calcium, may pave the way for cheaper and safer electrical energy storage. Here we report a new type of solid calcium hydridoborate electrolyte, Ca(BH4)2·2NH2CH3, with a high ionic conductivity of σ(Ca2+) ~ 10‐5 S cm‐1 at T = 70 °C, which is assigned to a relatively open and flexible structure with apolar moieties and weak dihydrogen bonds that facilitate migration of Ca2+ ions in the solid state. The compound display a low electronic conductivity, providing an ionic transport number close to unity (tion = 0.9916). Calcium plating is observed for a Ca|Ca(BH4)2·2NH2CH3|Pt electrochemical cell and the electrodes are investigated using scanning electron microscopy (SEM) combined with energy‐dispersive X‐ray spectroscopy (EDS) that reveal a rugged Ca anode surface owing to the stripping process and the presence of Ca‐containing domains on the Pt working electrode from the plating process. Improved electrochemical reversiblity was achieved in a three‐electrode cell configuration using a CaxSn counter and reference electrode and a Sn working electrode, CaxSn|Ca(BH4)2·2NH2CH3|Sn, providing reversible Ca plating and stripping.

Towards Solid-State Batteries Using a Calcium Hydridoborate Electrolyte.

Solid-state batteries created from abundant elements, such as calcium, may pave the way for cheaper and safer electrical energy storage. Here we report a new type of solid calcium hydridoborate electrolyte, Ca(BH4)2·2NH2CH3, with a high ionic conductivity of σ(Ca2+) ~ 10-5 S cm-1 at T = 70 °C, which is assigned to a relatively open and flexible structure with apolar moieties and weak dihydrogen bonds that facilitate migration of Ca2+ ions in the solid state. The compound display a low electronic conductivity, providing an ionic transport number close to unity (tion = 0.9916). Calcium plating is observed for a Ca|Ca(BH4)2·2NH2CH3|Pt electrochemical cell and the electrodes are investigated using scanning electron microscopy (SEM) combined with energy-dispersive X-ray spectroscopy (EDS) that reveal a rugged Ca anode surface owing to the stripping process and the presence of Ca-containing domains on the Pt working electrode from the plating process. Improved electrochemical reversiblity was achieved in a three-electrode cell configuration using a CaxSn counter and reference electrode and a Sn working electrode, CaxSn|Ca(BH4)2·2NH2CH3|Sn, providing reversible Ca plating and stripping.

3D Bioprinted Multidrug Resistance (MDR)-Dependent Tumor Spheroids.

Multidrug resistance (MDR) refers to the ability of cancer cells to resist various anticancer drugs and release them from the cells. This phenomenon is widely recognized as a significant barrier that must be overcome in chemotherapy. MDR varies depending on the number and expression level of the ATP-binding cassette transporter (ABC transporter), which is expressed differently in various cancer cells. Therefore, the dose of anticancer drugs should be adjusted according to the extent of MDR. The demand for drug screening that considers the differences in MDR is increasing in the process of drug discovery. In this study, three types of tumor spheroids were fabricated from HeLa (MRP1-/BCRP-), HepG2 (MRP1+/BCRP-), and A549 cells (MRP1+/BCRP+) using three-dimensional (3D) bioprinting. The fabricated tumor spheroids maintained their own MDR phenotypes. The EC50 values of doxorubicin (DOX) against the three tumor spheroids were more than 2-fold higher than those against the 2D cells. In addition, the EC50 value of DOX against tumor spheroids was proportional to the number of ABC transporters. The EC50 value of DOX against A549 tumor spheroids had the largest value of 9.5 μM among the three spheroids. In addition, the EC50 values of DOX against HepG2 and A549 tumor spheroids were remarkably reduced when they were treated with ABC transporter inhibitors, such as MK-571 against MRP1 and/or NOV against BCRP. These results demonstrate the successful construction of a 3D bioprinting-based screening platform to quantitatively evaluate the anticancer efficacy of chemodrugs, considering the MDR of cancer cells.