Metal-organic frameworks (MOFs), constructed by inorganic secondary building units with organic linkers via reticular chemistry, inherently suffer from poor solution processability due to their insoluble nature, resulting from their extensive crystalline networks and structural rigidity. The ubiquitous occurrence of precipitation and agglomeration of MOFs upon formation poses a significant obstacle to the scale-up production of MOF-based monolith, aerogels, membranes, and electronic devices, thus restricting their practical applications in various scenarios. To address the previously mentioned challenge, significant strides have been achieved over the past decade in the development of various strategies aimed at preparing solution-processable MOF systems. In this review, the latest advance in the synthetic strategies for the construction of solution-processable MOFs, including direct dispersion in ionic liquids, surface modification, controllable calcination, and bottom-up synthesis, is comprehensively summarized. The respective advantages and disadvantages of each method are discussed. Additionally, the intriguing applications of solution-processable MOF systems in the fields of liquid adsorbent, molecular capture, sensing, and separation are systematically discussed. Finally, the challenges and opportunities about the continued advancement of solution-processable MOFs and their potential applications are outlooked.