Abstract magnified imageA series of 5,7‐diarylpyrido[2,3‐d]pyrimidine‐2,4(1H,3H)‐diones was synthesized via the reaction of 6‐aminopyrimidine‐2,4‐dione and α,β‐unsaturated ketones in ionic liquid without using any catalyst. This protocol has the advantages of easier work‐up, milder reaction conditions, high yields, and environmentally benign procedure over traditional methods. J. Heterocyclic Chem., 2010.