High-speed pellet fuelling experiments have been performed on the ISX-B device in a new regime characterized by large global density rise in both Ohmically and neutral-beam heated discharges. Hydrogen pellets of 1 mm in diameter were injected in the plasma midplane at velocities exceeding 1 km·s−1. In low-temperature Ohmic discharges, pellets penetrate beyond the magnetic axis, and in such cases a sharp decrease in ablation is observed as the pellet passes the plasma centre. This behaviour can be accounted for by an ablation model that includes dynamic cooling of the target plasma while the ablation proceeds. Complete penetration can be prevented by operation in low-density regimes where runaway electrons are thought to be responsible for high ablation. A similar effect is observed with moderate to large amounts of neutral-beam injection. There is a strong enhancement of the ablation rate in the outer 10-cm plasma region even for short heating intervals, which can be explained by the presence of multi-kilo-electron volt ions in the discharge. Density increases of ∼300% have been observed without degrading plasma stability or confinement. Energy confinement time increases in agreement with the empirical scaling τE ∼ ne and central ion temperature increases as a result of improved ion-electron coupling. Laser-Thomson scattering and radiometer measurements indicate that the pellet interaction with the plasma is adiabatic. The low level of power emission from the pellet-plasma interaction region is consistent with negligible charge-exchange losses; within the experimental accuracy, nearly all of the pellet mass can be accounted for in the initial plasma density rise. Penetration to r/a ∼ 0.15 is optimal, in which case large-amplitude sawtooth oscillations are observed and the density remains elevated. Gross plasma stability is dependent roughly on the amount of pellet penetration and can be correlated with the expected temporal evolution of the current density profile.