Iodine Concentration Research Articles

ПІДСУМКИ ТА ПЕРСПЕКТИВИ ПІДВИЩЕННЯ ХАРЧОВОЇ ЦІННОСТІ ПАЙКІВ ДЛЯ ВІЙСЬКОВОСЛУЖБОВЦІВ ПІДРОЗДІЛІВ, ЩО ВЕДУТЬ АВТОНОМНІ БОЙОВІ ДІЇ

The article considers the results and prospects of increasing the nutritional value of rations for servicemen of units conducting autonomous combat operations. As an example, the intelligence unit of the Ground Forces of the Armed Forces of Ukraine (SV AFU) is considered. An analysis of improving the quality of rations due to the introduction of modern production technologies, such as microwave (ultra-high-frequency) processing and sublimation, was carried out. The main advantages of microwave processing are determined: the preservation of more nutrients, high processing speed, more uniform heating, economic energy consumption, a wide range of applications. The main advantages of sublimation have been determined: the preservation of the high quality of the product, natural aroma, taste, chemical structure, increase in shelf life, the stability of the process, which allows to ensure the same quality, and the quantity of the product in each batch, the maximum possible reduction in the mass of the finished product. The obtained research results indicate that the selectivity of microwave heating of microorganisms in a non-resonant chamber allows to reduce the exposure time of the product when it is processed in a uniform electromagnetic field by 4-5 times. It is noted that rational nutrition is an important factor in preserving and maintaining the health of military personnel, as well as maintaining their high combat capability. In order to increase the nutritional standards of servicemen of the units of the Armed Forces of the Armed Forces of Ukraine and provide them with high-quality food products enriched with vitamins and minerals, a commodity analysis of dry food rations used in Italy, Spain, Lithuania and Poland was carried out. It is proposed to improve the set of food products to the complex of combat equipment of a soldier, to which are attached: tablets for water disinfection (based on 1 liter per meal); a set of dry products with a high iodine content (for example, "kelp"); a set of dry products, dry products with a high protein composition (for example, "dried banana"). Keywords: ration, quality, nutritional value, microwave processing, sublimation, dry products.

Phenotypic Modulation of Adipose-Derived Stem Cells and Fibroblasts Treated with Povidone-Iodine and Chlorhexidine in Mono and Coculture Models.

Topical antiseptics are essential in wound treatment, and adipose-derived stem cells (ADSCs) have recently been proven to facilitate healing. However, the impact of antiseptics on ADSCs has not been fully elucidated, especially in relation to other relevant cell types present in the wound microenvironment, e.g., fibroblasts. This study evaluated the effects of chlorhexidine and povidone-iodine on four cellular constructs in 2D and 3D in vitro culture systems. Cell constructs were treated with two concentrations of each antiseptic, after which cell migration activity, α-SMA, and Ki67 marker expressions were assessed and compared. Both tested concentrations of povidone-iodine impaired migration and sprouting compared to chlorhexidine, which had minimal effects when used in low concentrations. The gap in the wound healing assay did not close after 24 h of povidone-iodine treatment, although, at the lower concentration, cells started to migrate in a single-cell movement pattern. Similarly, in 3D culture systems, sprouting with reduced spike formation was observed at high povidone-iodine concentrations. Both antiseptics modulated α-SMA and Ki67 marker expressions at 5 days following treatment. Although both antiseptics had cytotoxic effects dependent on drug concentration and cell type, povidone-iodine contributed more substantially to the healing process than chlorhexidine, acting especially on fibroblasts.

National and Sub-National Estimates of Household Coverage of Iodized Salt and Urinary Iodine Status among Women of Reproductive Age in India: Insights from the India Iodine Survey, 2018–19

BackgroundIodine deficiency is a significant public health problem for many populations worldwide, including India, particularly during the “first 1000 days” of life. Though Universal Salt iodization (USI) is mandatory in India, prior to 2018–19, there was no state-wide survey with estimates of iodine concentrations in salt using iodometric titration. Taking cognizance of this fact, Nutrition International commissioned the first-of-its-kind national-level survey in India, titled the India Iodine Survey 2018–19. ObjectivesThe study was conducted across the country to provide national and subnational estimates of iodine concentrations in household salt using iodometric titration and iodine nutrition status among women of reproductive age (15–49 y). MethodsThe survey adopted a multi-stage random cluster probability proportional to size sampling design, covering 21,406 households in all the states and union territories (UTs) of India. ResultsAt the national level, the household coverage of edible salt with adequate iodine (content ≥15 parts/million) was 76.3%. At the sub-national level, the coverage varied, with 10 states and 3 UTs achieving USI and 11 states and 2 UTs falling below the national average, with the highest among all the states and UTs, being Jammu and Kashmir and the lowest being Tamil Nadu. At the national level, the median urinary iodine concentration for pregnant women was 173.4 μg/L, for lactating women was 172.8 μg/L, and for non-pregnant, non-lactating women, it was 178.0 μg/L, which is within the adequate iodine nutrition range according to the WHO guidelines. ConclusionsThe survey results can be widely used by various stakeholders, including government, academia, and industry, to understand the iodine nutrition status of the population, enable the scale-up of sustained efforts toward consolidating gains and achieving USI, leading to the reduction and elimination of Iodine Deficiency Disorders.

Amorphous Transparent Cu(S,I) Thin Films with Very High Hole Conductivity.

Amorphous transparent conductors (a-TCs) are key materials for flexible and transparent electronics but still suffer from poor p-type conductivity. By developing an amorphous Cu(S,I) material system, record high hole conductivities of 103-104 S cm-1 have been achieved in p-type a-TCs. These high conductivities are comparable with commercial n-type TCs made of indium tin oxide and are 100 times greater than any previously reported p-type a-TCs. Responsible for the high hole conduction is the overlap of large p-orbitals of I- and S2- anions, which provide a hole transport pathway insensitive to structural disorder. In addition, the bandgap of amorphous Cu(S,I) can be modulated from 2.6 to 2.9 eV by increasing the iodine content. These unique properties demonstrate that the Cu(S,I) system holds great potential as a promising p-type amorphous transparent electrode material for optoelectronics.

Changes in Urinary Iodine Levels Following Bariatric Surgery

ObjectiveObesity has become an epidemic in the United States. Although bariatric surgery can effectively achieve weight loss by altering the gastrointestinal tract, it commonly results in micronutrient deficiency, requiring supplementation. Iodine is an essential micronutrient for the synthesis of thyroid hormones. We aimed to investigate changes in urinary iodine concentrations (UIC) in patients following bariatric surgery. Methods85 adults who underwent either laparoscopic sleeve gastrectomy or laparoscopic Roux-en-Y gastric bypass surgery were enrolled. At baseline and 3 months after surgery, we evaluated spot UIC and serum thyroid stimulating hormone (TSH), vitamin D, vitamin B12, ferritin, and folate levels. Participants provided a 24-hour diet recall for iodine-rich foods and information about multivitamin use at each time point. ResultsThere was a significant increase in median UIC (201 [120.0 – 288.5] vs 334.5 [236.3 – 740.3] μg/L; P < .001), a significant decrease in mean body mass index (44.0 ± 6.2 vs 35.8 ± 5.9; P < .001) and a significant decrease in TSH levels (1.5 [1.2 – 2.0] vs 1.1 [0.7 – 1.6] uIU/mL; P < .001) at 3 months postoperatively compared to baseline. Body mass index, UIC, and TSH levels before and after surgery did not differ based on the type of weight loss surgery. ConclusionIn an iodine-sufficient area, bariatric surgery does not cause iodine deficiency nor clinically significant changes in thyroid function. Different surgical procedures with different anatomical alterations in the gastrointestinal tract do not significantly affect iodine status.

Asymmetrical Methylene-Bridge Linked Fully Iodinated Azoles as Energetic Biocidal Materials with Improved Thermal Stability

The instability and volatility of iodine is high, however, effective iodine biocidal species can be readily stored in iodinated azoles and then be released upon decomposition or detonation. Iodine azoles with high iodine content and high thermal stability are highly desired. In this work, the strategy of methylene bridging with asymmetric structures of 3,4,5-triiodo-1-H-pyrazole (TIP), 2,4,5-triiodo-1H-imidazol (TIM), and tetraiodo-1H-pyrrole (TIPL) are proposed. Two highly stable fully iodinated methylene-bridged azole compounds 3,4,5-triiodo-1-((2,4,5-triiodo-1H-imidazol-1-yl)methyl)-1H-pyrazole (3) and 3,4,5-triiodo-1-((tetraiodo-1H-pyrrol-1-yl)methyl)-1H-pyrazole (4) were obtained with high iodine content and excellent thermal stability (iodine content: 84.27% for compound 3 and 86.48% for compound 4; Td: 3: 285 °C, 4: 260 °C). Furthermore, their composites with high-energy oxidant ammonium perchlorate (AP) were designed. The combustion behavior and thermal decomposition properties of the formulations were tested and evaluated. This work may open a new avenue to develop advanced energetic biocidal materials with well-balanced energetic and biocidal properties and versatile functionality.

Does Iodine Intake Modify the Effect of Maternal Dysglycemia on Birth Weight in Mild-to-Moderate Iodine-Deficient Populations? A Mother-Newborn Prospective Cohort Study.

It is unclear how maternal glycemic status and maternal iodine status influence birth weight among individuals with mild-to-moderate iodine deficiency (ID). We studied the association between birth weight and both maternal glucose levels and iodine intake among pregnant women with mild-to-moderate ID. Glucose values were assessed using a glucose challenge test (GCT) and non-fasting glucose levels that were determined before delivery; individuals' iodine statuses were assessed using an iodine food frequency questionnaire; and serum thyroglobulin (Tg) and urinary iodine concentrations (UIC) were used to assess each group's iodine status. Thyroid antibodies and free thyroxine (FT4) levels were measured. Obstetric and anthropometric data were also collected. Large-for-gestational age (LGA) status was predicted using a Cox proportional hazards model with multiple confounders. Tg > 13 g/L was independently associated with LGA (adjusted hazard ratio = 3.4, 95% CI: 1.4-10.2, p = 0.001). Estimated iodine intake correlated with FT4 among participants who reported consuming iodine-containing supplements (ICS) after adjusting for confounders (β = 0.4, 95% CI: 0.0002-0.0008, p = 0.001). Newborn weight percentiles were inversely correlated with maternal FT4 values (β = -0.2 95% CI:-0.08--56.49, p = 0.049). We conclude that in mild-to-moderate ID regions, insufficient maternal iodine status may increase LGA risk. Iodine status and ICS intake may modify the effect that maternal dysglycemia has on offspring weight.

Elemental Composition of Kelp Thalli (&lt;i&gt;Laminariae thalli&lt;/i&gt;) of Various Origins

Brown seaweeds (Laminariaceae) vary considerably in the content of toxic and essential elements; these variations depend on the taxonomic group and geographical factors. Seaweeds are extensively used in the food industry and widely applied in medicine for both humans and animals. Therefore, it is relevant to examine the correlation between the elemental composition and the geographical origin of kelp thalli obtained from different sources.The aim of the study was to collect, collate, and analyse primary and secondary data on the accumulation of essential, toxic and potentially carcinogenic elements, including iodine, in the thalli of brown seaweeds (Laminariaceae).Materials and methods. This study investigated the concentrations of 17 elements in Laminaria spp. (Al, As, Cd, Cr, Co, Cu, Fe, Hg, Mn, Mo, Ni, Se, Pb, Sr, V, Zn, and I). Experiments were conducted on an Agilent 7900 inductively coupled plasma mass spectrometer. The authors studied publications on the elemental composition of brown seaweeds (Laminariaceae) using literature search and data analysis methods.Results. This article reflects the updated classification of brown seaweeds (Laminariaceae) and summarises information about the mechanisms by which iodine and other elements accumulate in the thallus. The authors established species-specific variations in the order of element uptake and in the accumulation of elemental toxicants. The mutual influence of elements on their accumulation in brown seaweeds (Laminariaceae) was evaluated using Spearman’s rank correlation coefficients.Conclusions. The study results can inform the implementation of a risk-based quality control strategy for herbal medicinal products aimed at reducing human exposure to toxic elements. The authors suggest that the upper limit of iodine content in kelp-based food products should be standardised.

Associations of Maternal Serum Iodine Concentration with Obstetric Complications and Birth Outcomes—Longitudinal Analysis Based on the Huizhou Mother–Infant Cohort, South China

This study aimed to explore the temporal associations between maternal serum iodine concentration (SIC) and common pregnancy outcomes in Chinese women. Eligible singleton pregnant women aged 20–34 years were selected, and their fasting blood samples were collected during early (T1, n = 1101) and mid-pregnancy (T2, n = 403) for SIC testing by inductively coupled plasma mass spectrometry. Multivariable linear regression indicated that log10SIC at T1 (β = −0.082), T2 (β = −0.198), and their % change (β = −0.131) were inversely associated with gestational weight gain (GWG, all p &lt; 0.05). Maternal log10SIC at both T1 (β = 0.077) and T2 (β = 0.105) were positively associated with the Apgar score at 1 min (both p &lt; 0.05). Women in the third quartile (Q3) of SIC at T1 had a lower risk of small for gestational age (SGA, OR = 0.405, 95% CI: 0.198–0.829) compared with those in Q4. Restricted cubic spline regression suggested a U-shaped association between SIC and SGA risk, and SIC above 94 μg/L at T1 was the starting point for an increased risk of SGA. The risk of premature rupture of membrane (PROM) increased by 96% (OR = 1.960, 95% CI: 1.010–3.804) in Q4 compared to that in Q1. Our longitudinal data from an iodine-replete region of China indicated that high maternal SIC could restrict GWG and improve Apgar scores at delivery, but might increase the risk of SGA and PROM.

Effect of chitosan iodate complex biofortification on nutrient uptake in ‘shivam’ hybrid of tomato (Solanum lycopersicum L.)

Iodine deficiency occurs when iodine levels in the soil are inadequate, resulting in limited crop uptake and, as a result, a population with insufficient iodine intake. Iodine deficiency can be avoided by biofortifying commonly consumed crops with iodine. A field experiment was conducted to investigate the effect of iodine biofortification on the nutrient uptake of fruits and plants of ‘shivam’ hybrid tomato. Potassium iodate and chitosan were applied in the form of soil, foliar, and chitosan iodate complex with control comprising 16 treatments (T1 to T16) at different stages of plant growth. Iodine accumulation in tomato fruits and plants was achieved by combining foliar and iodine chitosan forms as electrostatic interaction between chitosan and iodate prevents volatilization and gradually increases the bioavailability of iodine from soil to fruits. Biofortification of iodine throughT14- Chitosan-KIO3Complex (CsKIO3) - (SA)-10Kgha-1 + FA-KIO3-0.3% @ 60 and 90 DAT the iodine content in tomato fruit at green (0.95ppm), pink (1.01ppm) and red ripen (0.99ppm) stages of tomato and introducing it in present-day daily diet may help to reduce iodine deficiency disorder. Iodine biofortification also influenced the uptake of nitrogen, phosphorous and potassium in plants and fruits of tomatoes.

Establishing a quality assurance program for photon counting detector (PCD) CT: Tips and caveats.

To determine the suitability of a quality assurance (QA) program based on the American College of Radiology's (ACR) CT quality control (QC) manual to fully evaluate the unique capabilities of a clinical photon-counting-detector (PCD) CT system. A daily QA program was established to evaluate CT number accuracy and artifacts for both standard and ultra-high-resolution (UHR) scan modes. A complete system performance evaluation was conducted in accordance with the ACR CT QC manual by scanning the CT Accreditation Phantom with routine clinical protocols and reconstructing low-energy-threshold (T3D) and virtual monoenergetic images (VMIs) between 40 and 120keV. Spatial resolution was evaluated by computing the modulation transfer function (MTF) for the UHR mode, and multi-energy performance was evaluated by scanning a body phantom containing four iodine inserts with concentrations between 2 and 15mg I/cc. The daily QA program identified instances when the detector needed recalibration or replacement. CT number accuracy was impacted by image type: CT numbers at 70keV VMI were within the acceptable range (defined for 120kV). Other keV VMIs and the T3D reconstruction had at least one insert with CT number outside the acceptable range. The limiting resolution was nearly 40 lp/cm based on MTF measurements, which far exceeds the 12 lp/cm maximum capability of the ACR phantom. The CT numbers in the iodine inserts were accurate on all VMIs (3.8% average percentage error), while the iodine concentrations had an average root mean squared error of 0.3mg I/cc. Protocols and parameters must be properly selected on PCD-CT to meet current accreditation requirements with the ACR CT phantom. Use of the 70keV VMI allowed passing all tests prescribed in the ACR CT manual. Additional evaluations such an MTF measurement and multi-energy phantom scans are also recommended to comprehensively evaluate PCD-CT scanner performance.

Dual-contrast photon-counting micro-CT using iodine and a novel bismuth-based contrast agent

Objectives. To characterize for the first time in vivo a novel bismuth-based nanoparticular contrast agent developed for preclinical applications. Then, to design and test in vivo a multi-contrast protocol for functional cardiac imaging using the new bismuth nanoparticles and a well-established iodine-based contrast agent. Approach. A micro-computed tomography scanner was assembled and equipped with a photon-counting detector. Five mice were administered with the bismuth-based contrast agent and systematically scanned over 5 h to quantify the contrast enhancement in relevant organs of interest. Subsequently, the multi-contrast agent protocol was tested on three mice. Material decomposition was performed on the acquired spectral data to quantify the concentration of bismuth and iodine in multiple structures, e.g. the myocardium and vasculature. Main results. In the vasculature, the bismuth agent provides a peak enhancement of 1100 HU and a half-life of about 260 min. After the injection, it accumulates in the liver, spleen and intestinal wall reaching a CT value of 440 HU about 5 h post injection. Phantom measurements showed that the bismuth provides more contrast enhancement than iodine for a variety of tube voltages. The multi-contrast protocol for cardiac imaging successfully allowed the simultaneous decomposition of the vasculature, the brown adipose tissue and the myocardium. Significance. The new bismuth-based contrast agent was proven to have a long circulation time suitable for preclinical applications and to provide more contrast than iodine agents. The proposed multi-contrast protocol resulted in a new tool for cardiac functional imaging. Furthermore, thanks to the contrast enhancement provided in the intestinal wall, the novel contrast agent may be used to develop further multi contrast agent protocols for abdominal and oncological imaging.

Iodine deficiency and real-life supplementation ineffectiveness in Polish pregnant women and its impact on thyroid metabolism.

Iodine is a pivotal component of thyroid hormones, and its deficiency leads to negative pregnancy outcomes. Therefore, during gestation, additional iodine supplementation is recommended. By evaluating a group of women from western Poland, the study updated on iodine status during pregnancy and the effectiveness of iodine supplementation in relation to the maternal and neonatal thyroid function. A total of 91 women were recruited before the delivery between 2019 and 2021. During the medical interview, the patients declared their dietary supplements intake. Thyroid parameters (TSH, ft3, ft4, a-TPO, a-Tg, and TRAb) were measured in the serum of mothers and in the cord blood of newborns after birth. Urinary iodine concentration (UIC) and urine/creatinine (UIC/crea) ratio were assessed in single urine samples using a validated high-performance liquid chromatography with ultraviolet detection (HPLC-UV). Neonatal TSH screening from dried blood spot was analyzed. Pregnant women showed a median (interquartile range) UIC of 106 (69-156) µg/liter and UIC/crea ratio of 104 (62-221) µg/g, whereas approximately 20% had UIC/crea below 50 µg/g, indicating iodine deficiency. The iodine supplementation ratio was 68%. No significant differences in UIC, UIC/crea and thyroid parameters were found between iodine supplemented and non-supplemented groups; however, the highest ioduria was detected when iodine was supplemented in addition to levothyroxine in comparison with both substances administered separately. Patients with UIC/crea within 150-249 µg/g demonstrated the lowest TSH and a-TPO levels. Screening TSH was above 5 mIU/liter in 6% of children. Despite the national salt iodization and the recommendation to supplement iodine during gestation, the status of the abovementioned microelement and real-life intake revealed the ineffectiveness of the current iodine-deficiency prophylaxis model in pregnancy.

Development of a dual energy CT based model to assess response to treatment in patients with high grade serous ovarian cancer: a pilot cohort study

BackgroundIn patients with cancer, the current gold standard for assessing response to treatment involves measuring cancer lesions on computed tomography (CT) imaging. The percentage change in size of specific lesions determines whether patients have had a complete/partial response or progressive disease, according to RECIST criteria. Dual Energy CT (DECT) permits additional measurements of iodine concentration, a surrogate marker of vascularity. Here we explore the role of changes in iodine concentration within cancer tissue on CT scans to assess its suitability for determining treatment response in patients with high grade serous ovarian cancer (HGSOC).MethodsSuitable RECIST measurable lesions were identified from the CT images of HGSOC patients, taken at 2 different time points (pre and post treatment). Changes in size and iodine concentration were measured for each lesion. PR/SD were classified as responders, PD was classified as non-responder. Radiological responses were correlated with clinical and CA125 outcomes.Results62 patients had appropriate imaging for assessment. 22 were excluded as they only had one DECT scan. 32/40 patients assessed (113 lesions) had received treatment for relapsed HGSOC. RECIST and GCIG (Gynaecologic Cancer Inter Group) CA125 criteria / clinical assessment of response for patients was correlated with changes in iodine concentration, before and after treatment. The prediction of median progression free survival was significantly better associated with changes in iodine concentration (p = 0.0001) and GCIG Ca125 / clinical assessment (p = 0.0028) in comparison to RECIST criteria (p = 0.43).ConclusionChanges in iodine concentration from dual energy CT imaging may be more suitable than RECIST in assessing response to treatment in patients with HGSOC.Trial RegistrationCICATRIx IRAS number 198179, 14 Dec 2015, https://www.myresearchproject.org.uk/.

Quantitative parameters derived from dual-energy computed tomography for the preoperative prediction of early recurrence in patients with esophageal squamous cell carcinoma.

This study aimed to assess the efficacy of quantitative parameters derived from dual-energy computed tomography (DECT) for the preoperative prediction of early recurrence (ER) in patients with esophageal squamous cell carcinoma (ESCC). In total, 78 patients with ESCC who underwent radical esophagectomy and DECT from June 2019 to August 2020 were enrolled in this study. Normalized iodine concentration (NIC) and electron density (Rho) in tumors were measured using arterial and venous phase images, whereas unenhanced images were used to determine the effective atomic number (Zeff). Univariate and multivariate Cox proportional hazards models were used to identify independent risk predictors of ER. Receiver operating characteristic curve analysis was performed using the independent risk predictors. ER-free survival curves were constructed using the Kaplan-Meier method. NIC in the arterial phase (A-NIC; hazards ratio [HR], 3.91; 95% confidence interval [CI], 1.79-8.56; p = 0.001) and pathological grade (PG; HR, 2.69; 95% CI, 1.32-5.49; p = 0.007) were identified as significant risk predictors of ER. The area under the curve of A-NIC for predicting ER in patients with ESCC was not significantly higher than that of PG (0.72 vs. 0.66, p = 0.441). In a stratified survival analysis, patients with high A-NIC or poorly differentiated ESCC had a higher rate of ER than those with low A-NIC or highly/moderately differentiated ESCC. A-NIC derived from DECT can be used to noninvasively predict preoperative ER in patients with ESCC, with an efficacy comparable to that of pathological grade. Preoperative quantitative measurement of dual-energy CT parameters can predict the early recurrence of esophageal squamous cell carcinoma and serve as an independent prognostic factor to guide clinical designation of personalized treatment. • Normalized iodine concentration in the arterial phase and pathological grade were independent risk predictors of early recurrence in patients with esophageal squamous cell carcinoma. • Normalized iodine concentration in the arterial phase may be a noninvasive imaging marker for preoperatively predicting early recurrence in patients with esophageal squamous cell carcinoma. • The efficacy of normalized iodine concentration in the arterial phase derived from dual-energy computed tomography for predicting early recurrence is comparable to that of pathological grade.

Nutrient Composition, Physicobiochemical Analyses, Oxidative Stability and Antinutritional Assessment of Abundant Tropical Seaweeds from the Arabian Sea.

Foods enriched with nutritional compounds and biological activities, especially antioxidants, are considered healthier for human and/or animal consumption. Seaweeds are rich sources of biologically active metabolites and are used as functional foods. In this study, proximate compositions, physicobiochemical characteristics and oil oxidative stability were analyzed for 15 abundant tropical seaweeds (four green-Acrosiphonia orientalis, Caulerpa scalpelliformis, Ulva fasciata, Ulva lactuca; six brown-Iyengaria stellata, Lobophora variegate, Padina boergesenii, Sargassum linearifolium, Spatoglossum asperum, Stoechospermum marginatum; and five red-Amphiroa anceps, Grateloupia indica, Halymenia porphyriformis, Scinaia carnosa, Solieria chordalis). All seaweeds were analyzed for the proximate composition, including moisture content, ash content, total sugar content, total proteins, total lipids, crude fiber, carotenoid content, total chlorophyll content, proline, iodine content, nitrogen-free extract, total phenolic content and total flavonoid content. Green seaweeds showed higher nutritional proximate composition, followed by brown and red seaweeds. Among the different seaweeds, Ulva, Caulerpa, Sargassum, Spatoglossum and Amphiroa showed high nutritional proximate composition compared to other seaweeds. High cation scavenging, free radical scavenging and total reducing activities were observed for Acrosiphonia, Caulerpa, Ulva, Sargassum, Spatoglossum and Iyengaria. It was also observed that 15 tropical seaweeds contained negligible amounts of antinutritional compounds, including tannic acid, phytic acid, saponins, alkaloids and terpenoids. Nutritionally, green and brown seaweeds provided higher sources of energy (150-300 calories per 100 g) compared to red seaweeds (80-165 calories per 100 g). Additionally, this study also confirmed that tropical seaweeds improved the oxidative stability of food oils and, therefore, might be recommended as natural antioxidant additives. The overall results confirm that tropical seaweeds are potential sources of nutrition and antioxidants and may be explored as functional food, dietary supplementation or animal feed. Additionally, they may also be explored as food supplements for fortifying food products, as food toppings or for garnishing and seasoning foods. However, a human or animal toxicity analysis is required before any conclusive recommendation for daily food or feed intake can be made.

Iodine status and its association with prevalence of thyroid diseases in adults from Jiangxi Province, China.

Iodine is an essential element for the biosynthesis of thyroid-stimulating hormone (TSH). Both excessive and deficient iodine are major risk factors for thyroid diseases, including thyroid dysfunction, thyroid nodules, and thyroid autoimmunity (TAI). This study aimed to elucidate the relationship between iodine status and the prevalence of thyroid diseases through a national cross-sectional epidemiological survey in Jiangxi province (China). This population-based, cross-sectional study enrolled 2636 Chinese local inhabitants who aged over 18 years old from April to August in 2015. Physical examination was performed and biochemical indices, urinary iodine concentration (UIC), and TSH level were measured. The Chi-square test, nonparametric test, and 4 multivariate logistic regression models adjusted for risk factors were applied to analysis. Spearman correlation coefficients were calculated to investigate the relationship between iodine intake level and the prevalence of thyroid diseases. The median UIC was 176.4 μg/L, and a significant difference was found in median UIC between men (182.45 μg/L) and women (169.25 μg/L) (P = 0.03). Among these study subjects, 14.4%, 44.5%, 26.1%, and 15.0% had deficient, adequate, more than adequate, and excessive iodine concentrations, respectively. The prevalence rates of hyperthyroidism, subclinical hyperthyroidism, hypothyroidism, subclinical hypothyroidism, thyroid nodules, and TAI were 0.91%, 0.57%, 0.34% and 7.89%, 9.45%, and 12.7%, respectively. Significant differences were found in iodine status, waist circumstance, systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), TSH, thyroid nodules, and TAI between men and women (P < 0.05). Compared with those with adequate UIC, subjects with excessive UIC had higher prevalence rates of thyroid dysfunction (odds ratio (OR) = 1.74, 95% confidence interval (CI): 1.40-2.54) and thyroid nodules (OR = 3.33, 95%CI 1.32-8.42). In addition, subjects with deficient and excessive UIC were at the higher risk of TAI compared with those with adequate UIC (OR = 1.68, 95%CI: 1.19-2.60; OR = 1.52, 95%CI: 1.04-2.96, respectively). UIC was positively correlated with the prevalence rates of thyroid nodules (r = -0.44, P < 0.01) and TAI (r = -0.055, P < 0.01). On the contrary, UIC was negatively correlated with the risk of thyroid dysfunction (r = -0.24, P > 0.05). Adult inhabitants from Jiangxi province in the TIDE study were in the adequate iodine status. Excessive iodine status was noted as a risk factor for thyroid dysfunction and thyroid nodules. In addition, both iodine deficiency and excessive iodine were risk factors for TAI.

Iodine biofortification of four microgreens species and its implications for mineral composition and potential contribution to the recommended dietary intake of iodine

The World Health Organization has identified iodine deficiency as one of the nutritional problems that affect more than a third of the world's population. About 60% of the world's population suffers from ‘hidden hunger’ with subtle and nonspecific health effects, regardless of social and economic status. The agronomic biofortification of leafy vegetables with iodine could increase the uptake of this crucial element. The current study constitutes the first report of results on the agronomic biofortification with iodine of four different species of microgreens (tatsoi, coriander, green basil, and purple basil). Biofortification was applied through the nutrient solution, using two doses of I (4 and 8 µM) plus an untreated control. Iodine supplementation across species had no effect on the dry matter content, color parameters, and nitrate levels of harvested microgreens. However, the 8 µM dose of iodine increased tissue iodine concentration by 226.52% (on average), with the highest values obtained from tatsoi (15.03 µg g − 1 fw). Taking into account the iodine recommended dietary allowance (RDA), consuming one serving of tatsoi biofortified with 8 µM I solution would cover 100.19% and 37.57% of daily requirement for adults and children, respectively. Our results demonstrated significant differences in the response of the four species to biofortification with iodine, highlighting the significant potential of select microgreens species for contributing to the combating of hidden hunger as an efficient and sustainable dietary resource.

Primary tumour iodine avidity in relation to uptake in persistent metastatic disease in papillary and poorly differentiated thyroid cancer

PurposePatients with persistent or recurrent papillary and poorly differentiated thyroid cancer can be effectively treated with radioiodine, if the tumour tissue is iodine-avid. However, iodine-avidity status is often unknown at the time of initial radioiodine treatment, limiting any adaptive approach. This study aimed to clarify the relationship between pre-therapeutic iodine avidity in primary tumour tissue, initial lymph node metastases and iodine uptake in subsequent metastases.MethodsIodine avidity was prospectively assessed pre-therapeutically in 35 patients by injection of tracer amounts of iodine-131 two days prior to surgery. Iodine concentrations in resected tissue samples were measured, enabling accurate and histologically verifiable iodine avidity data for both primary tumour and initial lymph node metastases. Iodine uptake in persistent metastatic disease was assessed by review of radiology, and treatment response was examined through journal studies.ResultsOut of data from 35 patients, 10 had persistent disease at presentation or during follow-up (range 19–46 months). Four patients had non-avid persistent metastatic disease, all with low iodine avidity in their primary tumours and initial lymph node metastases. Patients with low pre-therapeutic iodine avidity did not appear to have greater risk of persistent disease.ConclusionThe results indicate a close link between pre-therapeutically measured iodine concentrations in primary tumours with iodine avidity of any subsequent metastases.

Deep eutectic solvents based on ammonium iodide and iodine possessing high electrical conductivity

Herein, we have demonstrated the preparation of deep eutectic solvents (DESs) using ammonium iodides and iodine. Binary mixtures of 10 ammonium iodides with iodine were examined, and methylammonium iodide [MeNH3]I, diethylammonium iodide [Et2NH2]I, butylammonium iodide [BuNH3]I, and dibutylammonium iodide [Bu2NH2]I formed liquid DESs when mixed with iodine within specific concentration ranges. The DESs showed high electrical conductivities, which increased with the iodine concentration. Among the DESs studied here, [MeNH3]I/I2 with the molar ratio of 1:2.5 showed a very high electrical conductivity (approximately 100 mS cm−1 at 298 K). Overall, the viscosity of the DES series decreased with increasing iodine concentration. The Walden plot showed that most DESs studied here were good electrical conductors, whereas [Bu2NH2]I/I2 DESs with the molar ratios of 1:0.75 and 1:1.00 were almost ideal electrical conductors. Raman spectra of the DESs [Bu2NH2]I/I2 mixtures showed the presence of polyiodides; thus the high electrical conductivity of the DESs in this study was attributed to the Grotthuss mechanism.