Our laboratory at the Indian Institute of Science Education and Research (IISER) Mohali is involved in studying the intriguing conformational. characteristics of intrinsically disordered proteins (IDPs) that do not fold up into a well-defined 3D structure and exist as rapidly fluctuating conformational ensemble. Our research over the past decade or so has dealt with the IDPs and partially unfolded proteins and their conversion into amyloid aggregates that are associated with deadly neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s, and prion diseases. We were particularly interested in characterizing the monomeric and oligomeric precursors of amyloid fibrils. This work has been summarized in an invited Feature Article. The current article primarily deals with the newer research direction of our lab in liquid- liquid phase separation of IDPs. Here we summarize our recent exciting discoveries in phase separation of range of disease-related IDPs. Below we provide a background of the emerging field of biomolecular condensates and describe our published results.