In a context of increasing pressure on water resources and severe aridity; expansion in the reuse of naturally treated wastewater can be a viable and low-cost solution particularly for irrigation forests, green non-fruit trees, fabric crops, industrial oils, and non-edible raw crops. Wastewater treatment is increasingly recognized as a potential means in El-Wahat El-Bahariya in Egypt. However, investment decisions concerning the reuse of treated wastewater in irrigation needs to be justified in terms of financial and economic feasibility and profitability. Therefore, this research study aims to conduct a cost–benefit analysis (CBA) of an investment project “reuse treated wastewater in irrigation compared to other modes of water irrigation projects. The CBA results revealed that the cost of the initial investment for the production of treated water used for irrigating green non-fruit trees, Bamboo trees, and Cactus in Sekem El-Wahat, is economically efficient with 88% compared to the exploitation of aquifer groundwater for irrigating the same crops. That project allows for an economic gain of about 4,428.5 €/ha compared to the cost of producing aquifer ground water in Sekem Farm El-Wahat is estimated at 10,800 €/year. Substituting the use of aquifer ground water for irrigating crops with reuse of treated wastewater helps reducing energy consumption and offers great financial benefits to the beneficial communities. A net benefit of the reuse of treated wastewater project is largely positive with NPV equivalent to 4599 €/year with a medium economic efficiency (BCR) of about 0.44.