AbstractIn this communication, a new stochastic numerical paradigm is introduced for thorough scrutinization of the magnetohydrodynamic (MHD) boundary layer flow of Prandtl–Eyring fluidic model along a stretched sheet impact on thermal radiation as well as convective heating scenarios by exploiting the accurate approximation knacks of ANNs (artificial‐neural‐networks) modeling by using the inverse multiquadric (IMQ) function optimized/trained with well‐reputed global search with genetic algorithms (GAs) and local search efficacy of sequential quadratic programming (SQP), that is, ANNs‐IMQ‐GA‐SQP. The mathematical model of the Prandtl–Eyring fluid flow is portrayed in the form of PDEs and then converted in the form of a nonlinear system of ODEs by utilizing suitable similarity transformation to calculate/analyze the solution dynamics. The kinematic and thermodynamic properties of MHD Prandtl–Eyring fluid flow are examined/observed by varying the sundry physical parameters. The obtained intelligent computing designed solver‐based numerical results are consistently found in good agreement with reference results obtained through the Adams numerical technique. First and second‐order cumulant‐based statistical assessments are extensively exploited to endorse trustily the efficacy of ANNs‐IMQ‐GA‐SQP solver based on exhaustive simulations for the Prandtl–Eyring fluidic system.