Inverse Compton X-ray Sources Research Articles

Speckle tracking phase-contrast computed tomography at an inverse Compton X-ray source

Speckle-based X-ray imaging (SBI) is a phase-contrast method developed at and for highly coherent X-ray sources, such as synchrotrons, to increase the contrast of weakly absorbing objects. Consequently, it complements the conventional attenuation-based X-ray imaging. Meanwhile, attempts to establish SBI at less coherent laboratory sources have been performed, ranging from liquid metal-jet X-ray sources to microfocus X-ray tubes. However, their lack of coherence results in interference fringes not being resolved. Therefore, algorithms were developed which neglect the interference effects. Here, we demonstrate phase-contrast computed tomography employing SBI in a laboratory-setting with an inverse Compton X-ray source. In this context, we investigate and compare also the performance of the at synchrotron conventionally used phase-retrieval algorithms for SBI, unified modulated pattern analysis (UMPA) with a phase-retrieval method developed for low coherence systems (LCS). We successfully retrieve a full computed tomography in a phantom as well as in biological specimens, such as larvae of the greater wax moth (Galleria mellonella), a model system for studies of pathogens and infections. In this context, we additionally demonstrate quantitative phase-contrast computed tomography using SBI at a low coherent set-up.

External Radiation Assistance of Neutrinoless Double Electron Capture

The influence of electromagnetic radiation on nuclear processes is applied to an example of a neutrinoless double electron capture (0ν2ec). For cases with X-ray free-electron lasers (X-ray FELs) and/or inverse Compton X-ray sources, it was shown that such a decay can be significantly enhanced by tuning the system to the resonant conditions through the absorption and/or emission of a photon with the decay resonance defect energy Δ. In this case, the 0v2ec decay rate Γ2e of nuclide Z grew linearly with field intensity (S/Sz) up to the X-ray flux power Sm~Z6, while Sz~Z6 (Γ/Δ)2 with decay width Γ of a daughter atom. For the case of 78Kr → 78Se − 0ν2eL1L1 capture we find Sz~109 W cm−2 and Sm~1017 W cm−2 which indicate a possibility of increasing decay rate to eight orders of magnitude or even larger.

Ray Tracing Simulation of X-ray Microdiffraction Beamline on the Inverse Compton Source

This paper deals with the simulation of output beam parameters of the inverse Compton X-ray Source (ICS). The simulation takes into account the main parameters of the laser and electron beams, such as their pulse shapes, polarization properties as well as the angular and energy dispersion of the electrons. The layout of the presented ICS and X-ray optical beamline is dedicated to X-ray micro-diffraction studies. To maintain the axial symmetry of output X-ray beams at different photon energies, the beamline monochromator is based on a single crystal installed in the Borrmann transparency condition.

An Overview of the Radio-Frequency System for an Inverse Compton X-Ray Source Based on CLIC Technology

An Overview of the Radio-Frequency System for an Inverse Compton X-Ray Source Based on CLIC Technology

Precision radiotherapy using monochromatic inverse Compton x-ray sources.

The dosimetric properties of inverse Compton (IC) x-ray sources were investigated to determine their utility for stereotactic radiation therapy. Monte Carlo simulations were performed using the egs brachy user code of EGSnrc. Nominal IC source x-ray energies of 80 and 150keV were considered in this work. Depth-dose and lateral dose profiles in water were calculated, as was dose enhancement in the bone. Further simulations were performed for brain and spine treatment sites. The impact of gold nanoparticle doping was also investigated for the brain treatment site. Analogous dose calculations were performed in a clinical treatment planning system using a clinical 6MV photon beam model and were compared to the Monte Carlo simulations. Both 80 and 150keV IC beams were observed to have sharp 80-20 penumbra (i.e., < 0.1 mm) with broad low-dose tails in water. For reference, the calculated penumbra for the 6MV clinical beam was 3mm. Maximum dose enhancement factors in bone of 3.1, 1.4, and 1.1 were observed for the 80, 150keV, and clinical 6MV beams, respectively. The plan quality for the single brain metastasis case was similar between the IC beams and the 6MV beam without gold nanoparticles. As the concentration of gold within the target increased, the V12Gy to the normal brain tissue and within the target volume significantly decreased and the conformity significantly improved, which resulted in superior plan quality over the clinical 6MV beam plan. In the spine cases, the sharp penumbra and enhanced dose to bone of the IC beams produced superior plan quality (i.e., better conformity, normal tissue sparing, and spinal cord sparing) as compared to the clinical 6MV beam plans. The findings from this work indicate that inverse Compton x-ray sources are well suited for stereotactic radiotherapy treatments due to their sharp penumbra and dose enhancement around high atomic number materials. Future work includes investigating the properties of intensity-modulated inverse Compton x-ray sources to improve the homogeneity within the target tissue.

Spectroscopic imaging at compact inverse Compton X-ray sources.

While K-edge subtraction (KES) imaging is a commonly applied technique at synchrotron sources, the application of this imaging method in clinical imaging is limited although results have shown its superiority to conventional clinical subtraction imaging. Over the past decades, compact synchrotron X-ray sources, based on inverse Compton scattering, have been developed to fill the gap between conventional X-ray tubes and synchrotron facilities. These so called inverse Compton sources (ICSs) provide a tunable, quasi-monochromatic X-ray beam in a laboratory setting with reduced spatial and financial requirements. This allows for the transfer of imaging techniques that have been limited to synchrotrons until now, like KES imaging, into a laboratory environment. This review article presents the first studies that have successfully performed KES at ICSs. These have shown that KES provides improved image quality in comparison to conventional X-ray imaging. The results indicate that medical imaging could benefit from monochromatic imaging and KES techniques. Currently, the clinical application of KES is limited by the low K-edge energy of available iodine contrast agents. However, several ICSs are under development or already in commissioning which will provide monochromatic X-ray beams with higher X-ray energies and will enable KES using high-Z elements as contrast media. With these developments, KES at an ICS has the ability to become an important tool in pre-clinical research and potentially advancing existing clinical imaging techniques.

The versatile X-ray beamline of the Munich Compact Light Source: design, instrumentation and applications.

Inverse Compton scattering provides means to generate low-divergence partially coherent quasi-monochromatic, i.e. synchrotron-like, X-ray radiation on a laboratory scale. This enables the transfer of synchrotron techniques into university or industrial environments. Here, the Munich Compact Light Source is presented, which is such a compact synchrotron radiation facility based on an inverse Compton X-ray source (ICS). The recent improvements of the ICS are reported first and then the various experimental techniques which are most suited to the ICS installed at the Technical University of Munich are reviewed. For the latter, a multipurpose X-ray application beamline with two end-stations was designed. The beamline's design and geometry are presented in detail including the different set-ups as well as the available detector options. Application examples of the classes of experiments that can be performed are summarized afterwards. Among them are dynamic in vivo respiratory imaging, propagation-based phase-contrast imaging, grating-based phase-contrast imaging, X-ray microtomography, K-edge subtraction imaging and X-ray spectroscopy. Finally, plans to upgrade the beamline in order to enhance its capabilities are discussed.

Energy-Dispersive X-ray Absorption Spectroscopy with an Inverse Compton Source

Novel compact x-ray sources based on inverse Compton scattering can generate brilliant hard x-rays in a laboratory setting. Their collimated intense beams with tunable well-defined x-ray energies make them well suited for x-ray spectroscopy techniques, which are typically carried out at large facilities. Here, we demonstrate a first x-ray absorption spectroscopy proof-of-principle experiment using an inverse Compton x-ray source with a flux of >1010 photons/s in <5% bandwidth. We measured x-ray absorption near edge structure and extended x-ray absorption fine structure at the silver K-edge (~25.5 keV) for a series of silver samples. We propose an energy-dispersive geometry specifically adapted to the x-ray beam properties of inverse Compton x-ray sources together with a fast concentration correction method that corrects sample inhomogeneities very effectively. The combination of our setup with the inverse Compton source generates x-ray absorption spectra with high energy resolution in exposure times down to one minute. Our results unravel the great benefit of inverse Compton scattering sources for x-ray absorption techniques in a laboratory environment, especially in the hard x-ray regime, which allows to probe absorption edges of high Z materials.

Dose and spatial resolution analysis of grating-based phase-contrast mammography using an inverse Compton x-ray source.

Purpose: Although the mortality rate of breast cancer was reduced with the introduction of screening mammography, many women undergo unnecessary subsequent examinations due to inconclusive diagnoses. Superposition of anatomical structures especially within dense breasts in conjunction with the inherently low soft tissue contrast of absorption images compromises image quality. This can be overcome by phase-contrast imaging.Approach: We analyze the spatial resolution of grating-based multimodal mammography using a mammographic phantom and one freshly dissected mastectomy specimen at an inverse Compton x-ray source. Here, the focus was on estimating the spatial resolution with the sample in the beam path and discussing benefits and drawbacks of the method used and the estimation of the mean glandular dose. Finally, the possibility of improving the spatial resolution is investigated by comparing monochromatic grating-based mammography with the standard one.Results: The spatial resolution is constant or also higher for the image acquired with monochromatic radiation and the contrast-to-noise ratio (CNR) is higher in our approach while the dose can be reduced by up to 20%.Conclusions: In summary, phase-contrast imaging helps to improve tumor detection by advanced diagnostic image quality. We demonstrate a higher spatial resolution for one mastectomy specimen and increased CNR at an equal or lower dose for the monochromatic measurements.

Visualizing treatment delivery and deposition in mouse lungs using in vivo x-ray imaging

The complexity of lung diseases makes pre-clinical in vivo respiratory research in mouse lungs of great importance for a better understanding of physiology and therapeutic effects. Synchrotron-based imaging has been successfully applied to lung research studies, however longitudinal studies can be difficult to perform due to limited facility access. Laboratory-based x-ray sources, such as inverse Compton x-ray sources, remove this access limitation and opens up new possibilities for pre-clinical small-animal lung research at high spatial and temporal resolution. The in vivo visualization of drug deposition in mouse lungs is of interest, particularly in longitudinal research, because the therapeutic outcome is not only dependent on the delivered dose of the drug, but also on the spatial distribution of the drug. An additional advantage of this approach, when compared to other imaging techniques, is that anatomic and dynamic information is collected simultaneously. Here we report the use of dynamic x-ray phase-contrast imaging to observe pulmonary drug delivery via liquid instillation, and by inhalation of micro-droplets. Different liquid volumes (4 μl, 20 μl, 50 μl) were tested and a range of localized and global distributions were observed with a temporal resolution of up to 1.5 fps. The in vivo imaging results were confirmed by ex vivo x-ray and fluorescence imaging. This ability to visualize pulmonary substance deposition in live small animals has provided a better understanding of the two key methods of delivery; instillation and nebulization.

Conceptual design of magnetic spectrometer for inverse-Compton X-ray source in MeV region

A novel magnetic spectrometer for Inverse-Compton X-ray source is proposed. Compton recoil electrons are generated by a lithium converter, and then confined by a complex collimator and spectrally resolved by a sector-shaped double-focusing magnet. A method of optimization for the converter is investigated, and the dependence of the best energy resolution on converting efficiency is quantitatively revealed. The configuration of the magnet is specially designed to cover a wide range of electron energy and to achieve a large collecting solid angle. The efficiency and relative energy resolution of the designed spectrometer, according to Monte-Carlo simulation using Geant4, are 10-4 e/p and about 5% respectively for 3 MeV photons.

X-ray phase-contrast tomosynthesis of a human ex vivo breast slice with an inverse Compton x-ray source

While the performance of conventional x-ray tube sources often suffers from the broad polychromatic spectrum, synchrotrons that could provide highly brilliant x-rays are restricted to large research facilities and impose high investment and maintenance costs. Lately, a new type of compact synchrotron sources has been investigated. These compact light sources (CLS) based on inverse Compton scattering provide quasi-monochromatic hard x-rays. The flux and brilliance yielded by a CLS currently lie between x-ray tube sources and third-generation synchrotrons. The relatively large partially coherent x-ray beam is well suited for the investigation of preclinical applications of grating-based phase-contrast and dark-field imaging. Here we present the first grating-based multimodal tomosynthesis images of a human breast slice acquired at a CLS to investigate the possibilities of improved breast cancer diagnostics.

Status of the inverse Compton backscattering source at Daresbury Laboratory

Inverse Compton scattering is a promising method to implement a high-brightness, ultra-short, energy tuneable X-ray source at accelerator facilities and at laser facilities using laser wake-field acceleration. We have developed an inverse Compton X-ray source driven by the multi-10-TW laser installed at Daresbury Laboratory. Polarized X-ray pulses will be generated through the interaction of laser pulses with electron bunches delivered by the energy recovery linac commissioned at the ALICE facility with spectral peaks ranging from 0.4 to 12 Å, depending on the electron bunch energy and the scattering geometry. X-ray pulses containing up to 10 7 photons per pulse will be created from head-on collisions, with a pulse duration comparable to the incoming electron bunch length. For transverse collisions the laser pulse transit time defines the X-ray pulse duration. The peak spectral brightness is predicted to be up to 10 21 photon/(s mm 2 mrad 2 0.1% Δ λ/ λ). Called COBALD, this source will be initially used as a short-pulse diagnostic for the ALICE electron beam and will explore the extreme challenges of photon/electron beam synchronization, which is a fundamental requirement for all conventional accelerator and laser wake-field-acceleration-based sources.