For fixed functions G,H:[0,∞)→[0,∞), consider the rotationally invariant probability density on Rn of the form μn(ds)=1 ZnG(‖s‖2)e−nH(‖s‖2)ds. We show that when n is large, the Euclidean norm ‖Yn‖2 of a random vector Yn distributed according to μn satisfies a thin-shell property, in that its distribution is highly likely to concentrate around a value s0 minimizing a certain variational problem. Moreover, we show that the fluctuations of this modulus away from s0 have the order 1∕n and are approximately Gaussian when n is large. We apply these observations to rotationally invariant random simplices: the simplex whose vertices consist of the origin as well as independent random vectors Y1n,…,Ypn distributed according to μn, ultimately showing that the logarithmic volume of the resulting simplex exhibits highly Gaussian behavior. Our class of measures includes the Gaussian distribution, the beta distribution and the beta prime distribution on Rn, provided a generalizing and unifying setting for the objects considered in Grote-Kabluchko-Thäle [Limit theorems for random simplices in high dimensions, ALEA 16, 141–177 (2019)]. Finally, the volumes of random simplices may be related to the determinants of random matrices, and we use our methods with this correspondence to show that if An is an n×n random matrix whose entries are independent standard Gaussian random variables, then there are explicit constants c0,c1∈(0,∞) and an absolute constant C∈(0,∞) such that sups∈RPlogdet(An)−log(n−1)!−c0 1 2logn+c1<s−∫−∞se−u2∕2du 2π<C log3∕2n, sharpening the 1∕log1∕3+o(1)n bound in Nguyen and Vu [Random matrices: Law of the determinant, Ann. Probab. 42(1) (2014), 146–167].