Objectives: To evaluate the risk factors of sonographically-guided hydrostatic reduction of intussusception in children.Methods: We retrospectively reviewed the medical records of 149 cases of intussusception over a 5-year period. The gender, age, duration of symptoms, the presence of vomit or hematochezia, the presence of free peritoneal fluid and fluid inside the intussusception, the initial location of the intussusception as confirmed by sonography along with the time of hydrostatic reduction were statistically analyzed to determine their effect on outcome.Results: The gender, age and the duration of symptoms have no significantly difference in the result of hydrostatic reduction. The success rate was significantly lower among intussusceptions with the presence of vomit or hematochezia, the present of free peritoneal fluid or contained entrapped fluid, and located in the left side of the abdomen (p < 0.05). Of those risk factors, the statistic analysis using Logistic regression model indicated that the importance was the present of fluid inside the intussusception (OR = 41.67) > the free peritoneal fluid (OR = 31.25) > vomit (OR = 10.42) > the initial location of the intussusception (OR = 8.13) in turn.Conclusions: The present of fluid inside the intussusception and the free peritoneal fluid, the presence of vomit, the initial location of the intussusception are the more important risk factor of sonographically-guided hydrostatic reduction of intussusception. Objectives: To evaluate the risk factors of sonographically-guided hydrostatic reduction of intussusception in children. Methods: We retrospectively reviewed the medical records of 149 cases of intussusception over a 5-year period. The gender, age, duration of symptoms, the presence of vomit or hematochezia, the presence of free peritoneal fluid and fluid inside the intussusception, the initial location of the intussusception as confirmed by sonography along with the time of hydrostatic reduction were statistically analyzed to determine their effect on outcome. Results: The gender, age and the duration of symptoms have no significantly difference in the result of hydrostatic reduction. The success rate was significantly lower among intussusceptions with the presence of vomit or hematochezia, the present of free peritoneal fluid or contained entrapped fluid, and located in the left side of the abdomen (p < 0.05). Of those risk factors, the statistic analysis using Logistic regression model indicated that the importance was the present of fluid inside the intussusception (OR = 41.67) > the free peritoneal fluid (OR = 31.25) > vomit (OR = 10.42) > the initial location of the intussusception (OR = 8.13) in turn. Conclusions: The present of fluid inside the intussusception and the free peritoneal fluid, the presence of vomit, the initial location of the intussusception are the more important risk factor of sonographically-guided hydrostatic reduction of intussusception.