Introduction Of Oxycodone Research Articles

The role of oxycodone/naloxone in pain management

ABSTRACT: Strong opioid analgesics are essential for pain treatment of moderate to severe intensity, regardless of its etiology. An important factor limiting safety and efficacy of opioids are side effects, particularly gastrointestinal. Constipation as part of opioid induced bowel dysfunction is one of the most common reason for discontinuation of strong opioids. Introduction of novel oxycodone/naloxone formulation is an attempt to resolve the problem of opioid induced gastrointestinal side effects. On the basis of clinical trials from 2008-2016 the authors discuss the applicability of oxycodone/naloxone prolonged release in management of different pain syndromes in humans, in cancer patients, in neuropathic pain patients, in the elderly, in acute post-operative pain and other clinical indications for example restless leg syndrome. Presented data indicate comparable or in some cases even better analgesic efficacy of oxycodone with naloxone and lower risk of gastrointestinal side effects, especially constipation, when compared to other strong opioids. The introduction of oxycodone with naloxone significantly expands treatment options for chronic pain patients, likewise improving safety and thus the effectiveness of treatment with strong opioids.

P-37 * OXYCODONE MISUSE

Oxycodone was first developed in Germany in 1916 in attempt to offer an alternative to existing opioids such as morphine, codeine and heroin. It was hoped that the introduction of Oxycodone would provide a more effective pain treatment and reduce the risk of dependencies developing. The Victorian Alcohol and Drug Association recognised an alarming increase in the amount of Oxycodone prescribed in the last 15 years. Oxycodone related deaths have increased concurrently from four deaths in 2000 to a staggering ninety seven deaths in 2009. The rate of opioid type prescriptions including Oxycodone per person aged 15–54 from 1995–2003 has increased across all jurisdictions within Australia. Turning Point Alcohol and Drug Centre conducted research for Ambo Project, which looked at recording all ambulance attendances for patients specifically with drug and alcohol concerns. While the number of call outs by the Melbourne Metropolitan Ambulance for 'other opioids' was relatively low compared with alcohol, the concerns lies within the growth margin of attendances. An enormous increase of 20.6% in just 1 year. The increased trends in prescribing Oxycodone has bought about further health issues including harms related to injecting Oxycodone. The Addiction Medicine Unit at Monash Medical Centre; Monash Health, audited the amount of reported IV Oxycodone user in comparison to the reported number of infective endocarditis during 2010 and 2011.