Introduction Of New Groups Research Articles

Supportive care in multiple myeloma

Multiple myeloma is one of the most commonly diagnosed blood cancers. Due to the introduction of new therapies in recent years, there has been significant progress in treating myeloma. Even so, with the introduction of new groups of drugs, there have been some adverse events. In addition to anti-myeloma treatment, patients require supportive therapies. This article presents the principles of supportive treatment in emergencies and discusses the toxicity associated with the use of new groups of drugs.

Preparation and characterization of modified silica eugenol nanocapsules and their interaction with leather

Aromatic leather products can cover the peculiar smell of traditional leather products. Microencapsulation is the main way of leather perfuming, but the interaction between microencapsulated fragrance and leather is lacking. This study mainly discussed the preparation of a silicon-based fragrance nanocapsules and their interaction with leather. (3-aminopropyl) triethoxysilane (APTES) modified silica nanoparticles (MSN) were prepared by sol-gel method and encapsulated eugenol, and MSN with an average particle size of 328.75 nm was obtained. According to results found that the zeta potential of silica is −38.35 mV, there is a strong electrostatic attraction between it and leather, according to infrared, thermogravimetric analysis, there are hydrogen bonding, van der Waals forces, chemical bonding and other non-covalent forces between them, and the adhesion force was found to be 30.74 ± 1.62 nN by AFM force curve. Combined with the adsorption thermodynamic model, leather has strong adsorption on MSN, and its adsorption behavior is physical adsorption. The introduction of new groups has a positive enhancement effect on the adsorption effect. Therefore, the MSN can be well applied to leather perfuming, to provide new ideas for in-depth understanding of the adsorption behavior and mechanism of action of microencapsulated fragrance in aromatic leather on the leather surface, and promotes the development of aromatic leather.

Studija direktnih troškova u anesteziologiji i reanimatologiji u Kliničkom centru Srbije

Introduction: Modern health care implies the continuous development of human resources and the application of pharmacoeconomic analyzes during the introduction of new methods of treatment in medicine. Aim: The aim of the paper is to compare and analyze: 1) the number of: operated patients, provided anesthesia services, hospital days in ICU and surgery interventions; 2) distribution of anesthetic services: general anesthesia, local anesthesia and anesthesia procedures and 3) the values of direct costs of anesthesiology and reanimatology, in 2006 and 2015 in order to propose measures of rationalization and savings of funds. Methods: This paper is part of an academic IV phase study, conducted at the Clinical Center of Serbia (CCS) with the permission of the Ethical Committee of the Medical Faculty of the University of Belgrade (470 / IV7) and harmonized with the European Union Directive. Direct costs of anesthesiological services of the Center for Anesthesiology and Reanimatology, by department of anesthesia in the maternal surgical clinics of the Clinical Center of Serbia in Belgrade, during 2006 and 2015, are included and analyzed. The subjects were all anesthetized patients, both sexes, children and adults. The numeric data is processed by Microsoft Office Excel 2003 and SPSS for Windows. For the analysis of the statistical significance of the number of patients, anesthesiologic services, hospital days in Intensive Care Units and surgical procedures was used Wilcox test. In order to analyze the percentage distribution of funds in the category of direct costs (personal costs, drugs, materials, analyzes and medical equipment), in 2015 compared to 2006 was used the hi-square matching test. Results: There is a statistically significant difference in the frequency of service categories within the scope of services in 2015 compared to 2006 (p <0.001), indicators of hospital work. There is a statistically significant difference in the frequency of anesthetic services in 2015 compared to 2006 (p <0.001). There is a statistically significant difference in the total direct cost of anesthesiology and reanimatology between 2006 and 2015 (p = 0.043). There is a statistically significant difference in the frequency of direct cost categories in 2015 relative to 2006 (p <0.001). In the period of recession and transition in 2006, 42% of funds for personal expenses were separated, for medicines and materials 29%, analyzes and medical devices 29%. The direct costs of anesthetic services would be at the annual level of 10% relative to the means of surgical activity. Without taking into account methodological concerns (organizational changes, introduction of new groups of drugs in the responsibility of anesthesiologists, limiting legal regulations, higher prices), after a ten-year period, the ratio of direct costs was changed in 2015, so that personal costs amount to 4%, drugs and materials amount to 94% and analysis and medical equipment amount to 2%. Conclusion: 1. The 10-fold decrease in personnel costs in 2015 statistics is certainly not a consequence of a change in the methodology, but a constant, chronic and progressive impairment of vocational work in total health care costs. 2. Anesthetist services are only visible during their stay in the operating room. It is evident that most of the services performed in: preoperative assessment and preparation, immediate postoperative and delayed, chronic treatment of critical patients, are either unrecognized or incorrectly attributed to surgical specialties. 3. The quality of the statistical data presented is indicating the lack of interest of the hospital administration in analyzing and utilizing the collected data in reducing and rationalizing health care costs. 4. Academic multicenter studies in pharmacoeconomics are needed to help doctors to achieve a better uniform standards of providing anesthesia services using evidence based medicine.

Stress-strain state investigation of the “YASUNI” shell by bionic architecture methods based on numerical modeling

It is hard to imagine architecture and construction without large-span shells of various applications and taking into consideration the requests of architects, the new achievements in numeral modeling of the surfaces and introduction of new groups of tailored surfaces, the appearance of new forms and types of thin-walled shell structures of this kind is inevitable. The bionic method of solving these tasks pushes the boundaries of these opportunities. The subject being studied is the stress strain state of new uncanonical shell “YASUNI”, designed of monolithic reinforced concrete with the use of modern finite element analysis settlement system. The form of the shell is built on the basis of images of the Ecuadorian flora. The form of the shell imitates a leaf of a flower laying on the lay of the land. The triangle finite-element mesh is created with a harmonic fusion of lily and daisy in a single structure. The shell is designed as a solid-cast one, made of different classes of reinforced concrete (В25, В30, В35) with thickness from δ = 5 cm to δ = 10 cm with a step 1 cm without contouring beams. The structure is subjected to self-weight. The article introduces the first results of the research of stress strain state of the shell “YASUNI”. The authors continue the research of the work this shell with different geometrical parameters, the boundary conditions with the addition of contour elements. Due to the computing complex SCAD OFFICE, precision of which is enough to perform calculations it is possible to reach the most advantageous technical-and-economic indexes of the researched uncanonical shell.

Synthesis and anti-HIV-1 activity of novel TSAO-T derivatives modified at the 2′- and 5′-positions of the sugar moiety

Novel analogues of the anti-HIV-1 agent TSAO-T, [1-[2′,5′-bis- O-(tert-butyldimethylsilyl)-β- d-ribofuranosyl]thymine]-3′-spiro-5″-(4″-amino-1″,2″-oxathiole-2″,2″-dioxide) a counterpart TSAO-m 3T were obtained by modifications at positions 2′ or 5′ of the sugar moiety. These compounds were evaluated for their inhibitory effect on HIV-1 and HIV-2 replication in cell culture. Introduction of new groups at the 5′-position (i.e. esters, benzylether and silylethers) resulted in compounds that were either inactive or less active than the parent compounds (TSAO-T and TSAO-m 3T). Attempts to introduce small silyl ether groups at this position were not successful since these products decomposed during purification. Similar modifications at the 2′-position had a much less pronounced influence on the anti-HIV-1 activity.

Meningococcal Meningitis in Sub-Saharan Africa: A Model for the Epidemic Process

Epidemic group A meningococcal meningitis follows a unique and distinctive pattern in sub-Saharan Africa. Advances in molecular and field epidemiology have begun to elucidate the mechanisms of meningococcal meningitis epidemics. Epidemics result from a complex combination of host, organism, and environmental risk factors. Recent studies suggest that "antigenic shifts" in group A meningococcal clones may trigger an outbreak of disease by suddenly decreasing herd immunity within a population. Although the introduction of new group A meningococcal strains into a susceptible population contributes to the likelihood of an epidemic, the presence of additional environmental factors, such as low humidity and coincident respiratory tract infections, are also necessary for an epidemic to occur. Despite the unique behavior of group A meningococcal disease in sub-Saharan Africa, the application of similar methods of epidemiological analysis may be useful for determining epidemic processes for other diseases.

Actiori of Phenyl Isocyanate on Insulin

DURING the past three years, we have been investigating the properties of proteins which have been treated with phenyl isocyanates1. This reaction is of special value for the introduction of new groups into proteins, since it is rapid and can be carried out in neutral or faintly alkaline solution (pH. 7–8) and at relatively low temperatures (5°–8° C.).