Purpose This systematic review aims to identify the key determinants of knowledge transfer (KT) activities among researchers. Design/methodology/approach This study systematically reviewed KT literature in academic settings from 1995–2023. The authors searched Web of Science and Scopus using predefined keywords, following PRISMA guidelines for screening and eligibility assessment. From 158 selected articles, the authors extracted data and conducted a descriptive analysis to map KT activities’ evolution. A narrative synthesis approach categorized determinants of researchers’ KT activities. Findings The systematic review findings revealed a general conceptual framework that categorizes the identified determinants of KT into four categories. At the individual level, the factors are related to the sociodemographic characteristics of the researcher (e.g. gender, age, experience), their psychological aspects (e.g. attitude, intrinsic motivation, intention) and personal characteristics (e.g. self-efficacy, communication skills). At the research team level, leadership style and team dynamics. At the organizational level, the findings emphasize university characteristics (e.g. size, structure and ranking), KT culture installed and university resources. At the inter-organizational level, the key determinants were funding sources, network strength and trust. Research limitations/implications The studies included in our database were different in terms of contexts, country of the study, the disciplines of KT and the types of KT activities examined. This variety restricts the direct comparison of research findings thus the generalizability of our conclusions. Future research should focus on specific contexts, disciplines, countries or types of KT activities to provide generalizable findings. Practical implications A better understanding of all the factors influencing KT among university researchers is essential for several reasons. First, it will enable the government to develop effective policies to promote KT ecosystems. Second, universities can create strategies, policies and programs to support researchers’ engagement in KT activities. Finally, researchers can be more strategic in their KT efforts. Originality/value This systematic review contributes to the literature by providing a comprehensive conceptual framework that identifies KT determinants at different levels and fills a gap in the existing literature that only addresses specific aspects of KT determinants. This framework can be a theoretical reference for future empirical studies. Furthermore, it practically provides recommendations for different actors including, government, universities and researchers.