Objective To study the effect of applying a new intravenous resuscitation solution to electrolyte imbalance in miniature pigs after seawater immersion injury. Methods A total of 20 Guizhou Ⅲ type miniature pigs aged 4 months were randomly divided to A and B groups, 10 in each. The seawater immersion injury model was used to soak sea water for 3 hours. The changes of electrolytes in miniature pigs before and after soaking were recorded. A group with intravenous infusion of 0.9% sodium chloride solution, and B group with new type of recovery liquid intravenous rehydration. Electrolyte changes after infusion were recorded and analyzed. Data of normal distribution measurement data were expressed as (±s). The data of electrolyte before and after immersion were analyzed by paired t test. After soaking, the relative data of electrolyte after sub-group rehydration were analyzed by independent sample t test. Results After seawater immersion, pH value were dropped from 7.39±0.06 and 7.39±0.04 to 7.32±0.05 and 7.33±0.05, serum K+ concentration elevated from (3.93±0.38) mmol/L and (3.93±0.42) mmol/L to (4.35±0.33) mmol/L and (4.37 ±0.14) mmol/L. Cl- concentration increased from (93.38±4.29) mmol/L and (92.88±3.79)mmol/L to (102.80±4.29) mmol/L and (103.50±2.46) mmol/L. Na+ concentration in serum were dropped from (140.64±4.99) mmol/L and (140.69±4.72) mmol/L to (136.80±4.32) mmol/L and (136.90±3.03) mmol/L. After normal saline and new type of recovery liquid rehydration respectively, group B with new recovery liquid, pH increased from 7.33±0.05 to 7.38±0.04 (P<0.05), serum concentration of K+ and Cl- concentration were dropped from (4.37±0.14) mmol/L and (103.50±2.46) mmol/L to (3.87±0.25) mmol/L and (94.15±4.23) mmol/L (P=0.005, P=0.007). The concentration of serum Na+ back up from (136.90±3.03) mmol/L to (139.30±3.06) mmol/L (P=0.038). A group of saline infusion after the various indicators did not change significantly. Conclusion The new intravenous resuscitation solution of miniature pigs electrolyte imbalance correction effect is significant, that the resuscitation solution has some clinical value for seawater immersion injury. Key words: Electrolytes; Swine, miniature; Seawater immersion wound; Recovery liquid