Purpose: Colonoscopy, a widely used procedure for diagnostic and therapeutic purpose, is relatively safe, but not free of complications, among which perforation is common, with 0.4-1.9% incidence. We report a case of colonic perforation presenting with subcutaneous emphysema, pneumomediatinum, and pneumoretroperitoneum complicating therapeutic colonoscopy. Case: A 62-year-old man underwent colonoscopy for evaluation of hematochezia of 1 month's duration. He had multiple colon polyps throughout the colon. Hot snare polypectomy was performed on an isolated right colon polyp, with the rest being removed with a biopsy or cold snare polypectomy. Immediately post procedure, he complained of severe pressure-like chest pain with no associated nausea, dyspnea, diaphoresis, or dizziness. He was noted to develop subcutaneous emphysema involving the neck and left shoulder. Oxygen saturation was 96% on room air. Cell count, comprehensive panel, and cardiac enzymes were normal. EKG showed no evidence of ischemia. Chest x-ray showed sub-diaphragmatic free air. CT scan showed extensive subcutaneous air in the lower part of the neck and mediastinum, along with a large amount of retroperitoneal air dissecting mesentery and around the liver. Free intraperitoneal air was not noted. He was evaluated by surgery service and admitted for observation and conservative management. Due to worsening abdominal pain and tenderness on palpation, he underwent emergent exploratory laparotomy, which did not reveal any evidence of bowel perforation. A colonic perforation was suspected, but not identified. It was postulated that a microperforation had closed spontaneously after decompression of the bowel. The patient continued to do well, and recovered from surgery. Discussion: Incidence of colon perforation is common with therapeutic, as compared to diagnostic, colonoscopy. Subdiaphragmatic free air suggest intraperitoneal perforation, whereas subcutaneous emphysema, pneumoretroperitoneum, and pneumomediatinum suggest extraperitoneal perforation. Extraperitoneal perforation without peritoneal signs can be treated conservatively with bowel rest and antibiotics. Microperforation usually close with omental adherence, and symptoms resolve within 24-48 hours.Figure: CT Chest showing pneumomediastinum.