Intraosseous Adenoid Cystic Carcinoma Research Articles

Oral and maxillofacial rehabilitation of a patient suffering from intraosseous adenoid cystic carcinoma

ABSTRACT Treatment of cancers of the head and neck may provoke sequelae that affect the quality of life of patients during and after treatment. Mouth-sinus communication resulting from partial or total surgical resection of the palate leads to the patient experiencing dysphagia, dysphonia and trismus, which can lead to social isolation of the individual. As a result, the work of the dental surgeon, together with the multidisciplinary team caring for cancer patients, is fundamental and can help with the diagnosis, assist in the management of chemotherapy and radiotherapy complications and enable postsurgical rehabilitation. The present study reports the case of a patient with adenoid cystic carcinoma in the right maxilla, who underwent a partial maxillectomy, the resulting sequela being mouth-sinus communication. The dental treatment was performed at the Hospital of the Federal University of Pelotas preoperatively, during and after treatment. At this time the patient is rehabilitated with an obturator prosthesis and is being monitored by the dental team and the head and neck surgeon.

Primary intraosseous adenoid cystic carcinoma of the mandible: a comprehensive review and analysis of four new cases with emphasis on morphologic, immunophenotypic, and molecular characteristics

To comprehensively review the clinical manifestations, imaging, diagnosis, treatment, and pathologic features of primary intraosseous adenoid cystic carcinoma (PIACC) of the mandible and analyze PIACC histopathology and molecular features in four cases. We reviewed the literature and retrospectively studied four cases of PIACC. The clinical and imaging findings of PIACC are similar to other malignant or borderline-malignant mandible tumors. The four cases of PIACC included three males and one female (aged between 41 and 58years). The histopathologic features of the tumors resembled those of ACC. We observed abundant osteoclasts resorbing bone at the leading edge of the tumors characterized by solid structure histology but not by the cribriform subtype. Additionally, all four cases showed abnormalities in the MYB gene and high expression of MYB protein. All patients survived for the duration of follow-up, and two patients had distant metastases (followed up for 3 to 36months). PIACC is extremely rare and is often clinically misdiagnosed. Different histologic subtypes could show different mechanisms of invasion of the mandible. MYB gene and protein expression abnormalities can be used as indicators for the precise diagnosis of PIACC.

A rare case report of intraosseous adenoid cystic carcinoma of the mandible

Adenoid cystic carcinoma (ACC) is an uncommon malignant tumor of the salivary glands. It generally involves the minor salivary glands, and the hard palate is the most common site. ACC presents as a slow growing mass with mild pain and usually demonstrates perinueral invasion. An intraosseous occurrence of ACC is a very rare and when it occurs the mandible is more commonly involved than the maxilla. A Pubmed search has revealed only 26 case reports of intraosseous ACC involving the mandible until date. Hence, reporting one such rare case of intraosseous ACC in a 49-year-old male patient involving the mandible.

Chemopreventive Effect of Toona Sinensis Leaf Extract During Dmba-Induced Hamster Buccal Pouch Carcinogenesis

INTRAOSSEOUS ADENOID CYSTIC CARCINOMA OF THE MANDIBLE: REPORT OF A RARE CASE Pouyan Amini Shakib, Oveis Khakbaz Baboli, Department of Oral and Maxillofacial Pathology, Babol University of Medical Sciences, Babol, Iran; Department of Oral and Maxillofacial Surgery, Babol University of Medical Sciences, Babol, Iran Intraosseous carcinomas of the jaws are rare destructive malignancies which may be found after distant metastasis; therefore it seems early diagnosis and radical resesection of the jaw are mandatory in order to increase the survival of the patients. Such neoplasms are usually divided into two main groups; first is carcinoma arising in a previous odontogenic cyst or tumor; second is non odontogenic de novo carcinoma of the jaws. Among non odontogenic de novo carcinomas of the jaws, which usually present a challenging diagnosis, squamous cell carcinoma and mucoepidermoid carcinoma are more common and well described in literature. Here, we report a rare intraosseous adenoid cystic carcinoma of the mandible in a 27 year old female referred to our center with slight swelling and parasthesia of the right of her face and evaluate the combination of clinical, radiograghic and microscopic findings in diagnosis process of such rare lesions.

Primary Intraosseous Adenoid Cystic Carcinoma in Mandible: Case Report

Primary Intraosseous Adenoid Cystic Carcinoma in Mandible: Case Report

Intraosseous adenoid cystic carcinoma of the mandible: a case report and review of the literature

AbstractThe aim of this study was to describe the clinical and histological feature of intraosseous adenoid cystic carcinoma (IACC) and the treatment modalities with review of the literature. The authors report a case of intraosseous cystic carcinoma of the anterior mandible in an otherwise healthy 47‐year‐old patient along with a brief review of the literature. The main complaint was swelling and numbness of the right side of the lower lip. Clinically and radiologically, IACC is indistinguishable from benign odontogenic tumours and cyst. Routine histopathological examination and immunohistochemistry of incisional biopsy revealed adenoid cystic carcinoma. The lesion was surgically excised with surgical margins, which subsequently reconstructed using an iliac crest bone graft and followed by denture construction. On clinical and radiographic review 3 years post‐operatively, the patient was well, free of symptoms with complete oral rehabilitation. The case demonstrates the features of IACC. Surgical excision with bone reconstruction and removable prosthetic replacement was effective in the treatment of this case. Regular follow‐up was recommended.

Primary Intraosseous Adenoid Cystic Carcinoma of the Jaw: Clinical and Histopathologic Analysis

Adenoid cystic carcinoma (ACC), formerly known as cylindroma, is a malignant epithelial neoplasm typically derived from the salivary glands. Of all salivary gland tumors, the incidence of malignant salivary gland tumor has been 15 to 32% in the parotid glands, 70 to 90% in the sublingual glands, and about 50% in the minor salivary glands. Intraosseous ACC of the jaw has rarely been reported and is poorly understood. The aim of the present study was to analyze this tumor clinically and histopathologically to improve the diagnosis, management, and treatment. We collected the records of 16 patients with intraosseous ACC from 1998 to 2013, who had been treated at our hospital, including clinical data and follow-up information. We then analyzed the patients' clinical features, diagnosis, treatment, and prognosis. The average age of the 16 patients was 56.8 years, and the male/female ratio was 0.8. The primary manifestations of the tumor were obviously different. Tumor excision was performed and followed by radiotherapy or chemotherapy, or both. The average follow-up period was 57.2 months, and the average follow-up period for patients who were alive and tumor free was 52.3 months. The survival rate was 68.8% after treatment. All these results were generally in agreement with those from previous reports. The differential diagnosis of intraosseous ACC from other common tumors of jaws should be determined by the clinical, radiographic, and histopathologic subtypes. For treatment, surgery is the first choice for patients, and radiotherapy or chemotherapy might improve the prognosis in the postoperative period. In addition, the histopathologic subtypes and biologic processes of ACC are related to patient prognosis.

Atypical case of primary intraosseous adenoid cystic carcinoma of mandible

The Primary central salivary gland neoplasms of the mandible are infrequent. Their clinical and radiographic features may be similar to odontogenic tumors, which are otherwise common. Their accurate diagnosis becomes troublesome. Hence, diagnosis should depend on stringent diagnostic criteria. Adenoid cystic carcinoma is well known for its prolonged clinical course and its tendency for delayed onset of distant metastases. The long-term survival of these patients is therefore poor. Treatment modalities include surgery, radiotherapy and chemotherapy. The purpose of this paper is to report a case of primary central adenoid cystic carcinoma of mandible with an atypical presentation.

Intraosseous adenoid cystic carcinoma of maxilla: A rare case report

Adenoid cystic carcinoma (ACC) accounts for approximately 6-10% of all salivary gland tumors. Palatal minor salivary glands, parotid, and sub-mandibular glands are usually affected. Rarely, these lesions arising intraosseously have been reported. Mandible is commonly involved than maxilla. The present case is a giant ACC involving the right maxilla. A thorough clinical and radiographic evaluation was performed to assess the involvement of surrounding vital structures along with a meticulous metastatic work-up. Computed tomography showed a giant lesion in maxilla encroaching the left nasal fossa, antrum, buccal space, and oral cavity. No metastasis was noted. Histological evaluation from multiple sites showed both cribriform and solid patterns. Radiotherapy was given as patient did not comply for surgery. Though central ACC is extremely rare, especially in maxilla, it should be included in the differentials for lesions in maxilla. A prompt diagnosis with treatment and long-term follow-up is advised in such cases.

Multiple osteolytic lesions of intraosseous adenoid cystic carcinoma in the mandible mimicking apical periodontitis

Adenoid cystic carcinoma (ACC) is a relatively rare epithelial tumour of the salivary glands in the maxillofacial region. About 40-60% of the patients develop distant metastases, which have been documented most commonly in the lung but also in brain, bone, liver, thyroid, spleen and pancreatic gland. A 55-year-old women with intraosseous ACC in the mandible mimicking apical periodontitis following curative resection and radiotherapy is presented. Three years later, multiple lung metastases were observed followed by chemotherapy. Five years after curative resection, the patient presented simultaneously with new expansive soft tissue in the pancreas and mammary gland as well as in the kidney found to be metastatic ACC. No case has been reported to date on the manifestation of distant metastases of intraosseous ACC in the breast and the kidney as described by these observations. Metastatic mammary gland ACC stained positive for epithelial growth factor receptor (EGFR) but was negative for HER-2/neu and Cyclooxygenase-2 (COX-2) expression.

Primary Intraosseous Adenoid Cystic Carcinoma of the Mandible: Histopathological and Immunohistochemical Analysis

Primary intraosseous salivary gland tumors of the mandible are rare, with mucopidermoid carcinoma being the most frequent, followed by adenoid cystic carcinoma (ACC). We present a case of a central ACC involving the mandible of a 46-year-old man. He presented an indurated swelling on the vestibular aspect of the left mandibular body and ipsilateral paraesthesia of the lower lip. A panoramic radiography revealed a large radiolucent area, with irregular margins, involving the body and ramus of the left mandible, and CT scan confirmed that the lesion was confined within the mandibular bone. The histopathological features were of an ACC. CT scan also revealed multiple nodular lesions in both lungs suggestive of metastases. The patient was surgically treated by hemi-mandibulectomy. The patient is well with no evidences of recurrences in the mandible. The present case shows that the clinical and immunohistochemical profile of primary intraosseous ACC is similar to what is found in ACC involving the salivary glands.

Primary intraosseous adenoid cystic carcinoma of the mandible with lung metastasis: a case report

Intraosseous adenoid cystic carcinoma is an extremely rare neoplasm with only 17 cases reported previously. A case of primary intraosseous adenoid cystic carcinoma of the mandible with lung metastasis in a 45-year-old man is reported, together with a brief review of the literature.

Central adenoid cystic carcinoma of the mandible: Case report and literature review of 16 cases

Central intraosseous adenoid cystic carcinoma (ACC) of the mandible, formerly known as cylindroma, is a rare neoplasm with only 16 cases reported in the literature. We describe the diagnosis, etiology, and treatment of a central ACC located in the mandibular premolar region. We also review the literature. This case illustrates 2 key facts regarding the diagnosis and etiology of ACC. First, central salivary gland tumors should be considered in the differential diagnosis of cystic lytic lesions in the mandible. Second, even though the origin of this type of tumor is still unknown, the presence of ectopic tissue anterior to the submandibular gland in the submandibular area indicates that this tumor might be made up of ectopic embryogenic inclusions.

Bilateral intraosseous adenoid cystic carcinoma of the mandible: report of a case with lung metastases at first clinical presentation

Malignant epithelial tumours arising in the jaws are very rare. Adenoid cystic carcinoma (ACC) represents approximately 7.5% of all carcinomas and only a few cases of intraosseous (central) ACC have been reported in the literature. The salient clinico-pathological features of a case of ACC, bilaterally occurring in the mandible of a young caucasian woman who also had lung metastases are reported to appropriately characterize such unusual lesions and discriminate them from other tumours that more commonly affect the mandible. The patient presented with a painful swelling of the right retro-molar area and paraesthesia of the ipsilateral lower lip and radiological investigations disclosed bilateral radiolucent lesions of the mandible with unequivocal signs of malignancy but without intra-lesional calcifications or association with teeth roots or cystic component. Conventional histological examination disclosed typical ACC with solid and cribriform growth patterns and extensive infiltration of the adjacent tissues. The diagnosis of intraosseous malignant salivary gland type neoplasms is very difficult in view of their rarity and lack of specific signs and mainly achieved after histological examination and complete clinico-radiological work up. As surgical treatment of the patient was not indicated, due to extensive neoplastic disease, the patient is being controlled with multimodal treatment, including chemo- and radiotherapy and is alive with persistent disease 3 years after the original diagnosis.

Central (Intraosseous) Adenoid Cystic Carcinoma of the Mandible: Report of a Case with Periapical Involvement

Primary intraosseous salivary gland tumors are rare, with mucopidermoid carcinoma being the most frequent histotype. The authors present a case of adenoid cystic carcinoma, located in the mandibular incisor region, associated with pain. Endodontic treatment resulted in increased pain and progressive mandibular expansion. An apicoectomy was conducted, and an intraosseous adenoid cystic carcinoma was diagnosed at histological examination. The patient was treated by wide surgical resection, and is alive and well without recurrences or distant metastases 14 yr after the original diagnosis. The case presented herein calls attention to the preoperative clinical diagnosis of periapical lesions. Radiologically, focal sclerosing osteitis, cementoblastoma, cementifying and ossifying fibroma, periapical cemental dysplasia, complex odontoma, and calcifying epithelial odontogenic tumor should be considered in the differential diagnosis. In addition the unusual occurrence of salivary gland tumors in intraosseous location stresses the importance of systematic histological examination of any tissue sample obtained after endodontic procedures.

Intraosseous adenoid cystic carcinoma of the mandible

Radiolucent lesions in the jaws usually are associated with pathology of odontogenic origin. An unusual case of an adenoid cystic carcinoma arising from within the mandible is described. The origin of central salivary tumours is discussed and the literature reviewed.