Objective: To correlate the blood pressure changes to intraocular pressure before and after Handgrip exercise Method: Healthy young male adults in the age group of 18-22 years were selected among general population. Sample size was 40. Heart rate and intra ocular pressure (IOP) were recorded at rest and after isometric Handgrip test Results: Handgrip predictably raised Systolic blood pressure has increased significantly from resting of 113.40±5.75 to 133.50±4.29 (p<0.001) immediately after Handgrip exercise SBP has returned back to resting level within 10 min after exercise. Diastolic blood pressure has increased from significantly from resting of 72.45±4.37 to 89.95±3.28 p<0.001) immediately after Handgrip IOP has returned back to baseline level within 10 min after exercise (p-0.001- sig). Right eye IOP has decreased significantly from resting 16.27±1.54 to 13.34±1.32 (p<0.001) after handgrip exercise. Left eye IOP has decreased significantly from resting 16.28±1.55 to 13.04±1.19 (p<0.001)immediately after handgrip exercise;p<0.05). Blood Pressure is significantly and negatively correlated with IOP (Pearson’s correlation coefficient, r = -0.352). Conclusion: Isometric Handgrip exercise induces raise in blood pressure and simultaneously lowers IOP which were significant. Hence may prove useful in normotensive glaucomatous patients