BSS Plus, a new intraocular irrigating solution, was compared to BSS (Balanced Salt Solution) in 100 cases of planned extracapsular cataract extraction with the insertion of a Simcoe posterior chamber intraocular lens. Surgery was standardized in all cases, and Healon was not used. Fifty patients received BSS Plus at surgery and 50 patients received BSS. Approximately 10–20 min of introcular irrigation was required for each case. Preoperative and postoperative corneal endothelial cell counts showed a decrease in cell density of 15.4% using BSS Plus, and a decrease of 22.7% using BSS. These differences were statistically significant (p < 0.05).