HomeRadiologyVol. 198, No. 3 PreviousNext ArticlesErratumPublished Online:Mar 1 1996https://doi.org/10.1148/radiology.198.3.910MoreSectionsPDF ToolsImage ViewerAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinked In Abstract"Musculoskeletal Neoplasm: Perineoplastic Edema versus Tumor on Dynamic Postcontrast MR Images with Spatial Mapping of Instantaneous Enhancement Rates," Radiology 1995; 197:831-839. Figure 2e should appear as below.[See Figure in the PDF File]Figure 2. Osteogenic sarcoma with muscle infiltration in a 13-year-old boy. (a) T1-weighted precontrast MR image (SE 800/30) shows a lesion with low signal intensity in the distal femur. Intramedullary tumor (black arrows) and a large extraosseous component (curved arrows) are seen. Note oil-water phantom (straight white arrow) used to mark the biopsy site. (b) T2*-weighted image (GRE 600/30, 30° flip angle) shows extraosseous tumor component (black arrows) with high signal intensity. Additional high signal intensity is seen in the adjacent muscle and soft tissue (white arrows). It is not certain whether this represents tumor infiltration or perineoplastic edema/edematous muscle. (c) Conventional T1-weighted postcontrast MR image (SE 800/30). Central tumor portions show no enhancement indicating tumor necrosis. Extraosseous tumor component (curved arrows) shows enhancement indicating viable tumor. Contrast enhancement is also seen in medial soft tissues and muscle (straight arrows) and may represent tumor infiltration or perineoplastic edema/edematous muscle. No clear differentiation is possible. (d) Dynamic MR image (GRE 39/5, 60° flip angle, 3.5 seconds per image) obtained before bolus administration of gadopentetate dimeglumine. Portions of the extraosseous tumor (arrows) are seen. (e) Dynamic MR image (GRE 39/5, 60° flip angle, 3.5 seconds per image) obtained 3.5 seconds after bolus administration of gadopentetate dimeglumine. Although this is the first dynamic postcontrast image, portions of the intraosseous tumor already show contrast enhancement (open arrows). Additionally, subtle contrast enhancement is present in the medial soft tissues (solid arrows). (f) Dynamic MR image (GRE 39/5, 60° flip angle, 3.5 seconds per image) obtained 7.0 seconds after bolus administration of gadopentetate dimeglumine. Intramedullary enhancement of tumor (open arrows) is even more apparent. Soft-tissue enhancement (solid arrows) has also increased[See Figure in the PDF File](g) Dynamic MR image (GRE 39/5, 60° flip angle, 3.5 seconds per image) obtained 17.5 seconds after bolus administration of gadopentetate dimeglumine. Intramedullary (open arrows) and soft-tissue (solid arrows) enhancement are more accentuated. (h) Slope image calculated on the basis of all 47 dynamic MR images. Signal intensity reflects the initial slope value of each pixel. High signal intensity (solid straight arrows), which indicates high initial slope values, is seen in the soft tissues and muscles medial to the lesion and is suggestive of tumor infiltration. Intramedullary viable tumor (open curved arrows) and extraosseous viable tumor (solid curved arrow) also show high signal intensity (ie, high initial slope values). Necrotic tumor (n) shows low signal intensity (ie, low initial slope values). (i) Surgical wedge specimen obtained at biopsy. Specimen extends from the skin (left) through yellow lobulated subcutaneous fat and red muscle to the variegated extraosseous tumor (t) (right). Lightly colored muscle tissue (arrow) is suspicious for tumor infiltration as confirmed with histologic examination. (j) Photomicrograph shows large eosinophilic muscle fibers with infiltrating tumor cells (t) on the right. (Hematoxylin-eosin stain; original magnification, x100.)Article HistoryPublished in print: Mar 1996 FiguresReferencesRelatedDetailsCited ByMusculoskeletal Radiology: Then and Now1Frieda Feldman, 1 August 2000 | Radiology, Vol. 216, No. 2Recommended Articles RSNA Education Exhibits RSNA Case Collection Vol. 198, No. 3 Metrics Altmetric Score PDF download