(ramp phase) and was kept at this level tor 5 rain (tonic: phase), Adaptive accommodation during the toinc phase is the intragastric volume increase attained during the tonic phase, Maximum accommodation capacity is the rate of volume increase (ml/s) in the tonic phase. At'commodatinn time is the time from the start of the tonic phase to the end of adaptive accommodation. The volume response was investigated in each individual on two separate days, once during fasting conditions and once following 200 ml of a liquid meal (Nutridrink | 200 kcal/200 ml) given 15 min before the start of the distension. Results: In response to the test meal, healthy controls had a signibcant increase in maximum gastric volume (from 428-+ 60 to 734 _+ 31 ml, p = 0.0005), adaptive accommodation during tonic phase (from 223 -+ 37 to 435 -+ 41 ml, p = 0002), and in accomnmdation time (from 91 _+ i4 to 190 -+ 23 s, p = 0.003) The test meal had, hm,vever, no efi~.'ct on maximum accommodation capacity (2.4-+0,4 vs. 23_+0.2 mL/s, p=0+8) The most pronounced difi'erences between health3, controls and patients with tunctiona| dyspepsia were seen during lasting: adaptive accommodation during tonic phase (223-+ 37 ml in healthy persons and 132 -+ ]9 ml in patients, p = 004) and maximum accommodation capacity (2.4 _+ 0.4 vs. 0.8 _+ 0.1 ml/s, p = 0.0009), After tbe meal, there were no sigmficant differences between the groups. In patients with diabetes, the most pronounced difterences were seen after the meal: adaptive accommodation during the tonic phase (435 -+ 41 ml in heahhy controls vs. 274_+ 51 ml in diabetics, p = 0+03)+ Using these relatively low pressures the symptom scoring was inconsistent. Conclusion: This barostat technique allows detailed analysis of the gastric volume responses, Patients with functional dyspepsia and healthy controls differed significantly during lasting conditions concerning the rate and extent of adaptive accommodation during the tonic phase of distenmon, Diabetics, however, differed from controls mainly in adaptive accommodation during the tonic phase of distension after a meal.