INTRODUCTION: Obesity is an expanding public health problem, resulting in more than half a billion adults worldwide who were considered obese in 2016. Similarly, in Puerto Rico, as stated by the Behavioral Risk Factor Surveillance System from the Centers for Disease Control and Prevention there was a prevalence of 32.9% in 2017. Intragastric balloon (IGB) placement is a weight loss alternative for obese patients with an inadequate weight loss response to diet and exercise. The aim of this study is to examine the efficacy and safety of the single-chamber fluid-filled IGB for weight loss and compare its results across different age groups. METHODS: We performed a database review of all consecutive patients from two outpatient GI clinics who underwent placement of an IGB. Our final analysis comprised of 239 IGB placements in 232 patients (mean age, 44.5 ± 10.3 years; 67% female; baseline BMI 42.1 ± 9.0). Efficacy outcomes included: the percentage of the total (%TWL) and excess weight loss (%EWL), and Body Mass Index (BMI) reduction at 3 and 6 months. Safety outcomes was measured as the number of patients who required early IGB removal (before 6 months). RESULTS: %TWL at 3 months was 10.4%, and 14.5% at 6 months. Overall, 92%, 74%, and 46% of patients lost 5%, 10%, and 15% of total weight at 6 months, respectively. %EWL was 22.1% and 30.3% at 3 and 6 months post-IGB placement, respectively. We observed a BMI reduction of 4.4 kg/m2 at three months and 6.3 kg/m2 at six months overall. Subgroup analysis revealed that females %EWL significantly higher than males (31.9% vs 25.9%, P-value < 0.05). Similarly, patients between ages 51-60 had the highest %EWL (37.3%, P-value < 0.05) among all studied age groups. Likewise, patients grouped by BMI ranges showed a significant weight loss compared to baseline (BMI 30-40 kg/m2 %TWL: 14.6%, BMI 40-50 kg/m2 %TWL: 15.0% and BMI ≥ 50 kg/m2 %TWL: 14.4%), yet there was no significant statistical difference between them. The balloon was safely removed at six months after placement in most patients, whereas in 13.0% of cases early removal was performed at an average of 11.7 weeks after placement (range, 2 days-23 weeks). CONCLUSION: Patients among ages 51- 60 showed a significant decrease in %EWL in comparison with other age groups. Women achieved a greater weight loss than men. Subgroup analysis revealed no statistical differences in weight loss percentage among different BMI ranges.