Arteriography is a well established method of evaluating intracranial diseases, but in extracranial tumors its usefulness has not been fully explored. In the past five years we have found it to have many important and practical applications in the management of selected lesions in the region of the head and neck (2, 4). In this paper we wish to review some of the broad applications of arteriography in this area. Its indications may be divided into the following three groups: A. Preoperative B. Postoperative C. Regional infusion technics (intra-arterial) A. Preoperative 1. Masses of Uncertain Origin: Arteriography is of value in demonstrating the anatomical extent of the tumor, the feeding vessels, and the degree of vascularity. In certain cases, it may even aid in the diagnosis and subsequent management. This method is particularly useful in areas which are not readily palpable, such as the orbit and nasopharynx. A few tumors give rise to a characteristic pattern, for instance, carotid body tumors (5). A typical example of this was observed in a 46-year-old woman with a swelling of the left side of the neck, first noted about two years before admittance to the hospital because of syncopal attacks. Left carotid angiography demonstrated a vascular well circumscribed tumor. Characteristically, the origins of the internal and external carotid arteries are spread apart (Fig. 1). This vascular pattern and location are so highly specific that arteriography for all practical purposes replaces standard incisional biopsy (4). In the vast majority of cases, carotid body tumors are fed by branches of the external carotid artery. Occasionally, however, with large tumors there may be feeding vessels from the thyrocervical trunk. These will be overlooked with standard carotid angiography. We have had one proved case of a carotid body tumor which produced lateral displacement of the carotid bulb, but was completely avascular. This is comparatively rare. A localized aneurysmal dilatation of one of the larger arteries in the neck or a very tortuous vessel is commonly mistaken for a carotid body tumor. The two conditions are, however, easily differentiated by arteriography. This type of problem was seen in a 64-year-old woman, who presented with a large pulsating mass just above the medial end of the right clavicle. She was admitted to the hospital because of recent attacks of dizziness. Right brachial arteriography revealed a vascular “;mass” due to aneurysmal dilatation and tortuosity of the distal end of the innominate and the commencement of the subclavian and common carotid arteries (Fig. 2). As previously stated, a few tumors, like those of the carotid body, give rise to characteristic patterns, but others show little or no deviation from the normal. As a general rule, in a given tumor the more vascular areas are the more malignant. This may indicate the best site for biopsy (3).