Intraoral Minor Salivary Gland Research Articles

Oncocytoma of an intraoral minor salivary gland: Report of a case and review of literature

Oncocytoma is a rare benign salivary gland tumor composed of oncocytes, which are large, epithelial cells with a granular eosinophilic cytoplasm and small, centrally located nuclei. 1 ed 2. Histological Typing of Salivary Gland Tumours. World Health Organization International Histological Classification of Tumours. Springer-Verlag, Berlin, Germany1991: 14 Google Scholar The tumor is also known by the more descriptive and less confusing terms of oxyphilic adenoma 2 Foote Jr, FW Frazell EL Atlas of Tumor Pathology. Tumors of the Major Salivary Glands. in: Armed Forces Institute of Pathology, Washington, DC1954: 137 Google Scholar and oxyphilic granular-cell adenoma. 3 Meza-Chavez L Oxyphilic granular cell adenoma of parotid gland (oncocytoma). Oral Surg. 1958; 11: 897 Abstract Full Text PDF Scopus (6) Google Scholar

Epithelial tumors of the lacrimal glands: a clinicopathologic study.

We report the clinicopathologic features of epithelial tumors of the lacrimal gland apparatus, which are rare and therefore represent a major challenge for diagnosis and treatment. Histologic material from 22 lesions was studied by light microscopy, histochemistry, and immunohistochemistry. A comparison with major and minor salivary gland tumors was performed to analyze the relative distribution of these tumors and to establish whether salivary glands and lacrimal gland tumors are similar or different in their pathologic appearance and clinical behavior. There were three benign pleomorphic adenomas and 19 malignant tumors. The gender distribution was equal. The ages of the patients ranged from 10 to 73 years (mean age, 46 years). Among the malignant tumors, adenoid cystic carcinoma was the most common (nine cases), followed by mucoepidermoid carcinoma (three cases). There were two cases each of malignant mixed tumor and adenocarcinoma. All mucoepidermoid carcinomas and the adenocarcinomas were histologically high grade. There also was one case each of salivary duct carcinoma, spindle cell carcinoma, and oncocytic adenocarcinoma. Of 14 patients in whom clinical follow-up was available, seven had distant metastases and four died of their disease. The only case occurring in a child was an adenoid cystic carcinoma that recurred locally after 14 years. The clinical and pathologic features of lacrimal gland tumors resemble those lesions that arise in the intraoral minor salivary glands. The greater relative proportion of malignant cases in this series probably reflects a selection bias.

A clinicopathologic study of 196 intraoral minor salivary gland tumours.

We present a retrospective study of 196 patients with intraoral minor salivary gland tumours, 128 malignant and 68 benign, diagnosed from 1954 to 1993 in the A. C. Camargo Hospital, São Paulo, Brazil. Sixty-five percent of the cases occurred in the palate, followed by tongue (9.7%) and retromolar area (6.1%). Pleomorphic adenoma was the most common benign tumour, and mucoepidermoid carcinoma was predominant among the malignant tumours. Surgery was the main treatment method and postoperative radiotherapy and radiotherapy alone were used in 40 and 15 patients, respectively. Local recurrence was observed in two patients with pleomorphic adenoma and in eight patients with malignant tumours. Regional lymph node metastases occurred in four cases and distant metastases in five. Forty-six of 47 patients with benign tumours who were followed up from 1 to 7 years were alive without disease. Twenty-four of 79 patients with malignant tumours who were followed up for at least 5 years died due the tumour and 47 were alive without disease.

Polymorphous low-grade adenocarcinoma of the sublingual gland

A case of polymorphous low-grade adenocarcinoma occurring in the sublingual gland is described, followed by a brief discussion on the differential diagnosis. This is the first case ever reported of this entity occurring in the sublingual gland. This paper brings into question the early belief that this tumor is restricted to intraoral minor salivary glands.

Intraoral minor salivary gland tumors: A demographic and histologic study of 200 cases.

In a demographic and histologic study of 200 intraoral minor salivary gland tumors seen in Japan (Nagasaki and Miyagi prefectures), 127 cases (63.5%) were classified as benign, comprising 124 pleomorphic adenomas and 3 monomorphic adenomas. The other 73 cases (36.5%) were malignant tumors, represented by 33 adenoid cystic carcinomas, 16 mucoepidermoid carcinomas, 10 carcinoma in pleomorphic adenomas, 6 acinic cell carcinomas, 5 adenocarcinomas, one polymorphous low-grade adenocarcinoma, one undifferentiated carcinoma and one clear cell carcinoma. There was an overall female preponderance (1.78/1). The mean age for females was 47.2 years and for males was 50.6 years. The mean age for patients with malignant tumors was 10 years greater than for patients with benign tumors and was statistically significant. The palate was the most common site for intraoral minor salivary gland tumors followed by the lip and buccal mucosa. These three sites accounted for 83% of all cases. Tumors arising in these three sites were predominantly benign. In contrast, those located in the gingiva, floor of the mouth and tongue were predominantly malignant. The results of this study were compared with other recent studies.

Tumors of the intraoral minor salivary glands: A demographic and histologic study of 426 cases

In a demographic and histologic study of 426 oral minor salivary gland tumors, 57.5% were classified as benign and 42.5% were classified as malignant or potentially malignant. There was an overall female preponderance ( 1.59 1 ). The mean age for females was 53.1 years and for males was 50.6 years. The mean age for patients with malignant tumors was 5.4 years greater than for patients with benign tumors and was statistically significant. The palate was the most common site for oral minor salivary gland tumors followed by the upper lip and the buccal mucosa. These three sites accounted for 76.1% of all cases. Pleomorphic adenoma was the most common benign tumor (41% of all cases and 71% of benign tumors) followed by monomorphic adenoma of the canalicular and basal cell subtypes (10% of all tumors and 18.9% of benign lesions). Mucoepidermoid carcinoma was the most commonly encountered malignant tumor, accounting for 15.2% of all tumors and 35.9% of malignant lesions. Low-grade (teminal duct, lobular, polymorphous) adenocarcinoma was the most second most common type, making up 11% of all tumors and 26.4% of all malignant tumors. The results of this study are compared with other recent studies.

Intra-oral benign solid oncocytoma

Oncocytomas are extremely uncommon in the intra-oral minor salivary glands, they are rarely reported in the literature and the histopa-thology and clinical details are inadequately documented. This has led to uncertainty with regard to the behaviour and prognosis of this type of lesion. A case of benign solid oncocytoma arising from intra-oral minor salivary glands is reported here with a brief review of the petinent literature.

Myoepithelioma of salivary glands: report of 23 cases.

Twenty-three neoplasms arising in major and minor salivary glands have been found to be composed of two types of myoepithelial cells--the plasmacytoid and spindle-cell form. Twelve of these were located within the parotid gland and the submandibular gland and intraoral minor salivary glands accounted for five each. A solitary example was found within the upper lip. Sixteen (70%) of the cases were of the spindle-cell type, four (17%) were composed of plasmacytoid cells, and three cases (13%) contained both cell forms in approximately equal quantity. Differences in behavior, recurrence rate, frequency, age of the patient, and location were not related to cell type. Ultrastructural analysis of selected cases showed myofilament aggregation patterns to vary between the two subtypes. Previously published cases confirmed by electron microscopy have been reviewed and compared with the 23 cases reported. Conservative surgical management is curative. Follow-up information on 16 cases is presented.

Nodular and Ulcerated Lesions of the Hard Palate

Necrotizing sialometaplasia cannot be diagnosed clinically and has frequently been misdiagnosed microscopically. The fact that the disease can be misinterpreted as cancer is sufficient cause for the clinician to question a malignant diagnosis of an ulcerated or nodular lesion, especially one of the hard palate, that developed rather rapidly. When performing a biopsy of these lesions, care should be taken to ensure adequate size and depth of the specimen, as small biopsy tissue samples might include only the necrotic and actively regenerating portions of the lesion, thus causing diagnostic problems. Necrotizing sialometaplasia certainly should be considered in a differential diagnosis of soft tissue lesions arising in the vicinity of intraoral minor salivary glands, especially on the hard palate.

Acinic cell carcinoma of intraoral minor salivary gland origin

A case of acinic cell carcinoma involving minor salivary gland tissue is reported. This is an exceptional occurrence. The response to radiotherapy is described and it is suggested that this form of treatment should be considered in these cases.

Intraoral Cancer of the Minor Salivary Glands

Intraoral minor salivary gland carcinomas are relatively uncommon. The glands are concentrated in the mucosa of the mouth but occur over a wide area in the head and neck region. Little is known about the etiologic factors responsible for these tumors. Histologically, most salivary gland tumors are similar to those occurring in the parotid gland, but are more likely to be malignant. The most common presentations is an asymptomatic submucosal mass on the palate in a patient in the fifth or sixth decade, although it can occur in any age group. Neck node metastases occur in about one fourth of these patients. Surgical resection is the treatment of choice; irradiation may be a useful adjunctive method of palliation. Multiple recurrences over a long period of time are the rule, with 5 year survival for all malignant lesions being 44.5 per cent. The survival decreases another 10 per cent for each succeeding 5-year period of follow-up.

Mucoepidermoid tumors of the intraoral minor salivary glands: a clinicopathologic study of 54 cases.

Abstract. Clinical, gross and microscopic features of 54 mucoepidermoid tumors of intraoral minor salivary glands were studied. Thirty‐four were further analyzed with regard to treatment and survival. Females predominated 2:1. The most common locations were palate, mandibular retromolar area and buccal mucosa. Mean duration was approximately 1 year, and most were asymptomatic. Fifty tumors were well‐differentiated; four were poorly‐differentiated. Growth pattern was generally infiltrative. Treatment was surgical in all cases. Mean follow‐up duration was 47.1 months. Three well‐differentiated tumors recurred once. One poorly‐differentiated tumor recurred three times. No metastases or deaths occurred. Narrow or involved margins were common to recurrent but also to many non‐recurrent tumors. Well‐differentiated tumors behaved benignly and are best treated by modest local excision. Jaw resection is generally unnecessary. The practice of considering all mucoepidermoid tumors to be malignant is challenged.

Intraoral, mucinous, minor salivary gland lesions presenting clinically as tumors

Two cases of an intraoral minor salivary gland lesion are described. They are, in the authors' experience, unique. The nature and classification of these lesions are not known, but they represent either hyperplasia or adenoma. Long-term follow-up is available for one of these patients, and he remains free of any disease after 10 years.

Intraoral minor salivary gland tumors: Report of thirty-eight cases

This series of thirty-eight intraoral minor salivary gland tumors consists of twenty-six benign and twelve malignant tumors. Twenty-three of the twenty-six benign tumors are mixed tumors, and eight of the twelve malignant tumors are low-grade mucoepidermoid tumors. The palate was the favored site for benign tumors (fourteen cases), whereas malignant tumors occurred most frequently in the retromolar pad (five cases). The most common clinical feature of all tumors was a painless swelling. The wide variation in the incidence of malignancy shown in published series of minor salivary gland tumors may be a result of two factors: (1) variation in histopathologic criteria for malignancy and (2) type of institution from which a series is reported.

Surgical management of tumors of intraoral minor salivary glands. Report of eighty cases.

Tumors of the minor salivary glands are relatively uncommon. During the past 100 years, these tumors have received scant attention in the medical literature and little information has accrued concerning their surgical management. This report presents and discusses the surgical management of eight benign and 72 malignant tumors of intraoral minor salivary glands. Each patient was operated upon by one of the authors and represents the largest individual series collected to date. The age, sex, site of tumor origin, presenting symptoms, duration of symptoms and histologic type are summarized. Surgical results including morbidity, mortality and follow-up data, which in some instances extends over an 18-year period, is presented. This study indicates that the individual entrusted with the initial treatment of these tumors has the prime opportunity to effect a “cure.” An “adequate operation” offers the optimal chance for a cure. Enucleation of malignant tumors of minor salivary glands is to be condemned. Prolonged follow-up is mandatory to determine the ultimate results of treatment rendered.

Adenoid cystic carcinoma (cylindroma) of the palate: Report of three cases

Three cases of adenoid cystic carcinoma of intraoral minor salivary gland origin have been presented. In all three cases the tumors occurred in the palate. Full clinical data, outlines of surgical procedures, and detailed histopathologic reports were given for the first two cases. No detailed clinical and surgical data were available for the third case, for which the biopsy specimen was received for histopathologic study. Two of the three patients were women and one was a man. In one case the tumor perforated the palate, creating an oro-antral fistula. The tumors were treated by excision in two cases and by enucleation in one. The tumors in the three cases presented a broad spectrum of structural variations.