Intraluminal Metastasis Research Articles

The case of successful treatment of a patient with endobronchial intraluminal metastasis of kidney cancer

Tracheal cancer accounts for less than 0.2 % of the total number of oncological diseases. The medical literature describes isolated cases of metastatic lesions of the trachea and bronchi from distant organs. Metastasis of kidney cancer is observed most often in the absence of early detection of the tumor. We present a case of successful treatment of intraluminal metastasis of kidney cancer into the trachea.

A Case of Metastatic Carcinoma of Anal Fistula Caused by Intraluminal Metastasis of Rectal Cancer

A Case of Metastatic Carcinoma of Anal Fistula Caused by Intraluminal Metastasis of Rectal Cancer

A Case of Small Bowel Obstruction Secondary to Intraluminal Metastasis from an Undiagnosed Metastatic Lung Cancer

Background: Small bowel obstruction is a common emergency general surgical presentation with multiple possible causes. Small bowel metastases from a primary lung cancer is unusual with one study showing only 0.9% of patients with primary lung cancer will have metastasis to the small bowel.Methods: We present a case of a 66-year-old fit male who was admitted at the Accident and Emergency Department unwell and septic with clinical and radiological findings of small bowel obstruction.Results: The patient resuscitated and brought to operation theatres despite no obvious cause of the obstruction in the Computerised Tomography (CT) scan of the abdomen and pelvis. Laparotomy revealed small bowel obstruction secondary to an intraluminal small bowel lesion. Post-operative CT scan chest and histopathology of the excised lesion showed metastatic adenocarcinoma of the small bowel from a newly diagnosed lung cancer. Post operatively, patient initially recovered well but he deteriorated rapidly due to hospital acquired pneumonia and passed away 15 days after initial presentation.Conclusion: The case highlights the need to be cognizant of rarer causes of common emergency general surgical complaints.

Severe blood loss anaemia and recurrent intussusceptions as first presentation of bowel metastatic renal cell carcinoma: A case report and review of the literature.

Renal cell carcinoma (RCC) may metastasize to almost any organ, but bowel metastases are highly unusual. A 75-year-old man presented with symptoms and signs of severe anaemia due to bowel bleeding and abdominal pain due to recurrent bowel intussusception. The patient underwent surgery and was identified to have intraluminal metastases from metastatic RCC. To the best of our knowledge, few cases of metastases from RCC manifesting as synchronous intraluminal polypoid tumours have been described in the literature. The present report focused on the importance of two aspects that must be considered: The role of accurate diagnosis and of surgery treating intestinal metastases that may lead to symptom control and prolonged survival.

Effect of enteral nutrition as replacement of traditional bowel preparation on the intraperitoneal and intraluminal disseminated tumor cells, recurrence and metastasis in patients with colorectal cancer

To study the effect of enteral nutrition as replacement of mechanical bowel preparation on peritoneal and intraluminal disseminated tumor cells, recurrence and metastasis in patients with colorectal cancer. A total of 120 colorectal cancer patients between March 2007 and December 2011 were enrolled prospectively and randomly divided into two groups. Group A (n=60) received preoperative bowel preparation with enteral nutrition fluid (30 ml·kg(-1)·d(-1)), without enema, taxative or antibiotics. Group B (n=60) underwent traditional intestinal preparation consecutively 3 days before operation, including fasting, oral antibiotic, and cleaning enema. All the patients received peritoneal lavage with 400 ml of normal saline at the time of laparotomy and 200 ml of the lavage fluid was collected. All the cases underwent distal colorectal lavage with 1000 ml of normal saline before anastomosis, and 500 ml of the lavage fluid was collected. Fluid samples were quickly sent for exfoliated cytological examination. The positive rates of exfoliated cancer cell in peritoneal cavity and intraluminal cavity, postoperative complication, recurrence and metastasis were compared between the two groups. In group A, exfoliated cancer cells were found in 5 of 60 cases (8.3%) in peritoneal lavage fluid and in 9 of 60 cases (15.0%) in distal colorectal lavage fluid, while in group B, cancer cells were found in 13 of 60 cases (12.5%) and 19 of 60 cases (31.7%) respectively. There were significant differences between group A and B (P=0.041, P=0.031). Fifty-five patients in group A were followed up from 16 to 46 months after surgery, as well 57 patients in group B. Rates of local recurrence and distant metastasis in Group A and B were 5.5% vs. 7.0% and 10.9% vs. 10.5% respectively. There were no significant differences (P=0.733, P=0.984). There was no significant difference in 3-year survival rate between the two groups (80% vs. 78%, P=0.312). Enteral nutrition instead of traditional bowel preparation can decrease the positive rate of disseminated cancer cells in peritoneal cavity or colorectal lumen, while dose not affect recurrence and metastasis rates in patients with colorectal cancer.

Detection of Intraluminal Tracheal Metastasis of Thyroid Papillary Carcinoma by 18F-FDG PET/CT

We present a case of a 66-year-old female patient with thyroid papillary carcinoma. On the fluorine-18 fluorodeoxyglucose (F18-FDG) positron emission tomography/computed tomography (PET/CT) performed for thyroglobulin elevation accompanied by negative radioiodine whole-body scan, there was an intense 18F-FDG uptake in the polypoid soft tissue invading the tracheal cartilage and extending into the lumen. Dedifferentiated tumor with high metabolic rate can be easily detected by 18F-FDG PET/CT.

Common bile duct obstruction by intraluminal colorectal metastasis without evidence of liver or intraabdominal nodal metastasis

Common bile duct obstruction by intraluminal colorectal metastasis without evidence of liver or intraabdominal nodal metastasis

Anal Metastasis of Colorectal Carcinoma Origin: Implications for Diagnosis and Treatment Strategy

Anal metastasis originating from colorectal carcinoma is a rare occurrence that severely affects the patient's quality of life. No standardized effective therapeutic strategy exists. Our aim was to examine clinicopathologic characteristics and outcome of patients with anal metastasis of colorectal origin, directing particular attention to underlying mechanisms of metastasis in relation to potential treatment strategies. We identified patients with anal metastasis of colorectal origin by reviewing medical records of patients treated for colorectal cancer in a tertiary teaching hospital in the Osaka region of Japan between 2002 and 2009, and by searching the PubMed and Japanese Ichushi databases for patients reported in the literature. Clinical and pathologic variables were examined, including location, depth, and lymph node status of the primary colorectal tumor; mode, timing, site, and symptoms of metastases; as well as treatment and prognosis. The mode of metastasis was classified as either intraluminal or lymphovascular on the basis of clinical history of anal disease and/or histologic analysis of a resected specimen. Of 851 patients with primary colorectal cancer treated at our institution, 6 patients (0.7%; 95% CI, 0.1-1.3%) had anal metastases, and 38 patients with anal metastases of colorectal origin were identified in the literature; 43 patients could be analyzed. The primary lesion was located in the left colon in all patients. The metastatic mechanism was identified as intraluminal in 35 patients and lymphovascular in 8 patients. Local recurrence after local resection was not reported in any patient with intraluminal metastasis, but was found in 3 patients with lymphovascular metastasis, although all 3 had undergone wide resection. The study was observational in nature and included a small number of patients. Treatment strategies for anal metastasis of colorectal carcinoma origin should consider the mechanism of metastasis. Patients with suspected lymphovascular metastasis should undergo radical resection beyond the primary and metastatic anal tumor to eradicate remnant cancer cells, together with preoperative chemoradiation therapy.

Superior vena cava syndrome as a complication of colon carcinoma

Superior vena cava syndrome is a group of signs and symptoms resulting from the impairment of blood flow through the SVC into the right atrium. We present a case of a 54-year-old female with superior vena cava syndrome due to metastasis of colon carcinoma into the SVC leading to an intraluminal obstruction. To our knowledge this is the first published report of an intraluminal metastasis of colon adenocarcinoma into the superior vena cava causing SVC syndrome.

A Case of Small Bowel Obstruction Due to Intraluminal Metastases from Metastatic Renal Cell Cancer

A 71-year-old man, with a history of metastatic renal cell cancer (RCC), presented with symptoms of a small bowel obstruction with nausea, vomiting, cramps, and diarrhea. He underwent surgery and was found to have intraluminal metastases from his metastatic RCC. Intraluminal metastases are rare and usually present with obstruction, bleeding, or perforation. The mainstay of treatment remains complete surgical excision, even in the face of widely metastatic disease. Surgery not only palliates symptoms, but may also extend survival because metastatic RCC can be a very indolent and unpredictable disease. Furthermore, these patients can now be treated with a new class of antiangiogenic agents that are showing impressive response rates, which may also translate into improved overall survival.

A Rare Case of Intraluminal Ureter Metastasis from Rectal Cancer

A Rare Case of Intraluminal Ureter Metastasis from Rectal Cancer

Case report: Two patients with symptomatic renal metastases

Two patients with symptoms referable to the urinary tract who were found to have renal metastatic disease are presented. The first case illustrates typical radiological features of metastatic malignancy affecting the kidney. In the second case angiographic features were suggestive of a grossly dilated renal collecting system conflicting with the sonographic appearances of a solid renal mass. At surgery the pelvicalyceal system and proximal ureter were found to be grossly distended with an intraluminal metastasis.

THE ASSOCIATED RADIOLOGIC AND ENDOSCOPIC EXAMINATION IN THE STUDY OF GASTRIC TUMORS

One hundred patients, suspected to be affected with gastric cancer, were examined at first roentgenologically and afterwards with a new gastroscope, the fiberscope. A correct diagnosis was performed by the radiologist in 79 patients, by the endoscopist in 87, and with the combined examinations in 91 cases. From the results obtained in this study, it appears that gastroscopy is specially indicated when x-ray findings are uncertain or when there is not agreement between radiological conclusions and clinical signs. In addition, the gastroscopic examination may be able to reveal a neoplastic degeneration of a gastric ulcer, still unsuspected by the radiologist. Gastroscopy has no advantages in the exploration of intramural lesions, but it is sometimes useful in large tumors, already radio-logically diagnosed, in order to discover distant intraluminal metastases.