Intra-arterial Chemoembolization Research Articles

Tissue Tolerance to Pelvic Intraarterial Chemoembolization with Cisplatin-Lipiodol Suspension

Tissue tolerance to pelvic intraarterial chemoembolization with cisplatin-lipiodol suspension was studied in rabbits. Cisplatin (3 mg/kg) was used with different doses of lipiodol (0.0, 0.1, 0.2, and 0.3 ml/kg). Cisplatin-lipiodol suspension was injected into the umbilical artery through a long polyethylene catheter. Local tissue concentration of platinum was increased with lipiodol, while that in the liver, heart, and kidneys was reduced. Tissue retention of platinum was linearly related to the dosage of lipiodol. With a single dose of 0.2 ml/kg lipiodol, only slight degeneration and sparse hemorrhage were observed without necrosis.

Therapy of bladder cancer.

Progress in the different modern methods of treatment influenced the strategy in the therapy of bladder cancer, adjusting it to the stage of the tumour. The basis of different ways of treatment is the transurethral tumour resection. Depending on the stage and grade resulting from this, further steps are taken. An exact indication for radical cystectomy and the possibility of an appropriate urinary diversion have improved the chances of success. Of the adjunctive measures we have to mention the intravesical cytostatic instillation therapy, the transurethral high-frequency hyperthermia and the intraarterial chemoembolization. The technique and the methods of application are presented here. An overall view is given of laser treatment and the immunological therapy of bladder cancer.

Papillary-cystic neoplasm of the pancreas with multiple hepatic metastases: A case report

We report a case of papillary-cystic neoplasm (PCN) of the pancreas in a 42-yr-old woman. Because of complication with multiple hepatic metastases, the patient could not receive radical operation, and was treated palliatively. The right hepatic tumors decreased in volume by an average of 28% (range: 13-54%) following intra-arterial infusion of doxorubicin and gelatine sponge--i.e. chemoembolization therapy. On the other hand, the left lobe tumor increased by 15% in volume following intra-arterial infusion of doxorubicin alone without selective embolization. A subsequent systemic combination chemotherapy (combinations of 5-fluorouracil, doxorubicin and mitomycin-C) was less effective for both the primary and metastatic sites of PCN of the pancreas. Intra-arterial chemoembolization proved useful--as expected--as a palliative measure. Papillary-cystic neoplasm of the pancreas accompanied by hepatic metastasis is very rare. We present herein its clinical behavior and response to the above treatment as documented by CT scan.