Building heterojunctions is a promising strategy for the achievement of highly efficient photocatalysis. Herein, a novel SnIn4S8@ZnO Z-scheme heterostructure with a tight contact interface was successfully constructed using a convenient two-step hydrothermal approach. The phase composition, morphology, specific surface area, as well as photophysical characteristics of SnIn4S8@ZnO were investigated through a series of characterization methods, respectively. Methylene blue (MB) was chosen as the target contaminant for photocatalytic degradation. In addition, the degradation process was fitted with pseudo-first-order kinetics. The as-prepared SnIn4S8@ZnO heterojunctions displayed excellent photocatalytic activities toward MB degradation. The optimized sample (ZS800), in which the molar ratio of ZnO to SnIn4S8 was 800, displayed the highest photodegradation efficiency toward MB (91%) after 20 min. Furthermore, the apparent rate constant of MB photodegradation using ZS800 (0.121 min-1) was 2.2 times that using ZnO (0.054 min-1). The improvement in photocatalytic activity could be ascribed to the efficient spatial separation of photoinduced charge carriers through a Z-scheme heterojunction with an intimate contact interface. The results in this paper bring a novel insight into constructing excellent ZnO-based photocatalytic systems for wastewater purification.