Disease Management Interventions Research Articles

Endoscopic full-thickness plication along with argon plasma coagulation for treatment of proton pump inhibitor dependent gastroesophageal reflux disease

BACKGROUND Most endoscopic anti-reflux interventions for gastroesophageal reflux disease (GERD) management are technically challenging to practice with inadequate data to support it utility. Therefore, this study was carried to evaluate the effectiveness and safety newer endoscopic full-thickness fundoplication (EFTP) device along with Argon Plasma Coagulation to treat individuals with GERD. AIM To evaluate the effectiveness and safety newer EFTP device along with Argon Plasma Coagulation to treat individuals with GERD. METHODS This study was a single-center comparative analysis conducted on patients treated at a Noble Institute of Gastroenterology, Ahmedabad, hospital between 2020 and 2022. The research aimed to retrospectively analyze patient data on GERD symptoms and proton pump inhibitor (PPI) dependence who underwent EFTP using the GERD-X system along with argon plasma coagulation (APC). The primary endpoint was the mean change in the total gastroesophageal reflux disease health-related quality of life (GERD-HRQL) score compared to the baseline measurement at the 3-month follow-up. Secondary endpoints encompassed enhancements in the overall GERD-HRQL score, improvements in GERD symptom scores at the 3 and changes in PPI usage at the 3 and 12-month time points. RESULTS In this study, patients most were in Hill Class II, and over half had ineffective esophageal motility. Following the EFTP procedure, there were significant improvements in heartburn and regurgitation scores, as well as GERD-HRQL scores (P < 0.001). PPI use significantly decreased, with 82.6% not needing PPIs or prokinetics at end of 1 year. No significant adverse events related to the procedures were observed in either group. CONCLUSION The EFTP along with APC procedure shows promise in addressing GERD symptoms and improving patients' quality of life, particularly for suitable candidates. Moreover, the application of a lone clip with APC yielded superior outcomes and exhibited greater cost-effectiveness.

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care.

The detection of levels of impairment in microvascular oxygen consumption and reactive hyperemia is vital in critical care. However, there are no practical means for a robust and quantitative evaluation. This paper describes a protocol to evaluate these impairments using a hybrid near-infrared diffuse optical device. The device contains modules for near-infrared time-resolved and diffuse correlation spectroscopies and pulse-oximetry. These modules allow the non-invasive, continuous, and real-time measurement of the absolute, microvascular blood/tissue oxygen saturation (StO2) and the blood flow index (BFI) along with the peripheral arterial oxygen saturation (SpO2). This device uses an integrated, computer-controlled tourniquet system to execute a standardized protocol with optical data acquisition from the brachioradialis muscle. The standardized vascular occlusion test (VOT) takes care of the variations in the occlusion duration and pressure reported in the literature, while the automation minimizes inter-operator differences. The protocol we describe focuses on a 3-min occlusion period but the details described in this paper can readily be adapted to other durations and cuff pressures, as well as other muscles. The inclusion of an extended baseline and post-occlusion recovery period measurement allows the quantification of the baseline values for all the parameters and the blood/tissue deoxygenation rate that corresponds to the metabolic rate of oxygen consumption. Once the cuff is released, we characterize the tissue reoxygenation rate, magnitude, and duration of the hyperemic response in BFI and StO2. These latter parameters correspond to the quantification of the reactive hyperemia, which provides information about the endothelial function. Furthermore, the above-mentioned measurements of the absolute concentration of oxygenated and deoxygenated hemoglobin, BFI, the derived metabolic rate of oxygen consumption, StO2, and SpO2 provide a yet-to-be-explored rich data set that can exhibit disease severity, personalized therapeutics, and management interventions.

The role of telehealth interventions in pulmonary rehabilitation programs for patients with chronic obstructive pulmonary disease (COPD)

Background: Telehealth interventions in chronic obstructive pulmonary disease (COPD) management have garnered attention for their potential to enhance access to care and improve patient outcomes. Various studies have explored the effectiveness of telerehabilitation programs, innovative telemedicine platforms, and home-based PR initiatives in addressing the needs of COPD patients. Methods and materials: A selection criterion was determined after a thorough literature review across search engines and databases. SANRA guidelines were followed to draft the manuscript. Objectives: Exploring the impact of telehealth interventions on the effectiveness and the outcomes of pulmonary rehabilitation programs for patients with COPD. Discussions: The discussions revolve around the positive impact of telehealth interventions on exercise capacity, self-efficacy, and quality of life for COPD patients. Studies highlight the convenience and accessibility offered by telemedicine platforms as well as the effectiveness of in-home telerehabilitation programs. However, challenges such as technical issues, data security concerns, and disparities in access to technology need to be addressed for successful implementation.

Towards a tailored approach for patients with acute diverticulitis and abscess formation. The DivAbsc2023 multicentre case–control study

BackgroundThis multicentre case–control study aimed to identify risk factors associated with non-operative treatment failure for patients with CT scan Hinchey Ib-IIb and WSES Ib-IIa diverticular abscesses.MethodsThis study included a cohort of adult patients experiencing their first episode of CT-diagnosed diverticular abscess, all of whom underwent initial non-operative treatment comprising either antibiotics alone or in combination with percutaneous drainage. The cohort was stratified based on the outcome of non-operative treatment, specifically identifying those who required emergency surgical intervention as cases of treatment failure. Multivariable logistic regression analysis to identify independent risk factors associated with the failure of non-operative treatment was employed.ResultsFailure of conservative treatment occurred for 116 patients (27.04%). CT scan Hinchey classification IIb (aOR 2.54, 95%CI 1.61;4.01, P < 0.01), tobacco smoking (aOR 2.01, 95%CI 1.24;3.25, P < 0.01), and presence of air bubbles inside the abscess (aOR 1.59, 95%CI 1.00;2.52, P = 0.04) were independent predictors of failure. In the subgroup of patients with abscesses > 5 cm, percutaneous drainage was not associated with the risk of failure or success of the non-operative treatment (aOR 2.78, 95%CI − 0.66;3.70, P = 0.23).ConclusionsNon-operative treatment is generally effective for diverticular abscesses. Tobacco smoking's role as an independent risk factor for treatment failure underscores the need for targeted behavioural interventions in diverticular disease management. IIb Hinchey diverticulitis patients, particularly young smokers, require vigilant monitoring due to increased risks of treatment failure and septic progression. Further research into the efficacy of image-guided percutaneous drainage should involve randomized, multicentre studies focussing on homogeneous patient groups.Graphical abstract

Digital Health Interventions in Older Adult Populations Living With Chronic Disease in High-Income Countries: Protocol for a Scoping Review.

Globally, around 80% percent of adults aged 65 years or older are living with at least 1 chronic disease, and 68% percent have 2 or more chronic diseases. Older adults living with chronic diseases require greater health care services, but these health care services are not always easily accessible. Furthermore, the COVID-19 pandemic has resulted in unprecedented changes in the provision of health care services for older adults. During the COVID-19 pandemic, digital health interventions for chronic disease management were developed out of necessity, but the evidence regarding these and developed interventions is lacking. In this scoping review, we aim to identify available digital health interventions such as emails, text messages, voice messages, telephone calls, video calls, mobile apps, and web-based platforms for chronic disease management for older adults in high-income countries. We will follow the Arksey and O'Malley framework to conduct the scoping review. Our full search strategy was developed following a preliminary search on MEDLINE. We will include studies where older adults are at least 65 years of age, living with at least 1 chronic disease (eg, cancer, cardiovascular disease, chronic obstructive pulmonary disease, and diabetes), and residing in high-income countries. Digital health interventions will be broadly defined to include emails, text messages, voice messages, telephone calls, video calls, mobile apps, and web-based platforms. This scoping review is currently ongoing. As of March 2023, our full search strategy has resulted in a total of 9901 records. We completed the screening of titles and abstracts and obtained 442 abstracts for full-text review. We are aiming to complete our full-text review in October 2024, data extraction in November 2024, and data synthesis in December 2024. This scoping review will generate evidence that will contribute to the further development of digital health interventions for future chronic disease management among older adults in high-income countries. More evidence-based research is needed to better understand the feasibility and limitations associated with the use of digital health interventions for this population. These evidence-based findings can then be disseminated to decision-makers and policy makers in other high-income countries. DERR1-10.2196/49130.

Performance of fur clips and livestock markers for identifying vaccinated badgers

Marking free-living wild mammals may be desirable during field studies and management interventions; however, doing so presents practical challenges. In the context of disease management interventions, different approaches such as vaccination and culling may be deployed in adjacent areas resulting in a need to identify previously vaccinated individuals to avoid losses of vaccination benefits. Badgers (Meles meles) have been identified as a wildlife reservoir of bovine tuberculosis in several countries. In England, the primary means of controlling disease in badger populations has been culling, although policy also includes the use of badger vaccination. Vaccination and culling can therefore increasingly take place in adjacent areas. The current means of marking vaccinated badgers is to apply a fur clip; however, the performance of this method has not been assessed. In this study, we assessed the field performance of livestock markers not previously trialled on badgers. We also assessed the performance of fur clips in terms of (a) how likely they are to be detected on recapture and (b) their detectability using remote cameras. None of the livestock markers trialled persisted well on badger fur. Detectability of fur clips on re-captured badgers fell to 50% in adult badgers by approximately 3 months from application. In cubs, detectability fell to less than 50% within 3 weeks of application. We suggest it is highly likely that, if vaccination and culling were carried out in adjacent areas and fur clipping was the primary means of determining vaccination status, a proportion of recently vaccinated badgers would be removed, particularly cubs. This has important implications for disease control, and we suggest options for minimising such losses.

A randomized multicenter trial of a chronic disease management intervention for decompensated cirrhosis. The Australian Liver Failure (ALFIE) trial.

Improving the care of decompensated cirrhosis is a significant clinical challenge. The primary aim of this trial was to assess the efficacy of a chronic disease management (CDM) model to reduce liver-related emergency admissions (LREA). The secondary aims were to assess model effects on quality-of-care and patient-reported outcomes. The study design was a 2-year, multicenter, randomized controlled study with 1:1 allocation of a CDM model versus usual care. The study setting involved both tertiary and community care. Participants were randomly allocated following a decompensated cirrhosis admission. The intervention was a multifaceted CDM model coordinated by a liver nurse. A total of 147 participants (intervention=75, control=71) were recruited with a median Model for End-Stage Liver Disease score of 19. For the primary outcome, there was no difference in the overall LREA rate for the intervention group versus the control group (incident rate ratio 0.89; 95% CI: 0.53-1.50, p=0.666) or in actuarial survival (HR=1.14; 95% CI: 0.66-1.96, p=0.646). However, there was a reduced risk of LREA due to encephalopathy in the intervention versus control group (HR=1.87; 95% CI: 1.18-2.96, p=0.007). Significant improvement in quality-of-care measures was seen for the performance of bone density (p<0.001), vitamin D testing (p<0.001), and HCC surveillance adherence (p=0.050). For assessable participants (44/74 intervention, 32/71 controls) significant improvements in patient-reported outcomes at 3 months were seen in self-management ability and quality of life as assessed by visual analog scale (p=0.044). This CDM intervention did not reduce overall LREA events and may not be effective in decompensated cirrhosis for this end point.

Effectiveness of Telemedicine Interventions in Chronic Obstructive Pulmonary Disease (COPD) Management: A Randomized Controlled Trial Comparing Yoga Therapy and Pulmonary Rehabilitation Over Three Months.

Background Pulmonary rehabilitation (PR) is an integral part of non-pharmacological therapy in chronic obstructive pulmonary disease (COPD). Yoga therapy (YT) has been shown to be beneficial in COPD, but the lack of large well-designed trials and standardized modules restricts its acceptability. This randomized control trial compares these two modalities in COPD patients via supervised tele-intervention. Objectives The primary objective of the study is to compare a 45-minute, five-days-per-week series of tele-YT (T-YT) with tele-PR (T-PR) for three months in terms of exercise capacity (6-Minute Walk Distance (6MWD)) in COPD patients. Methods COPD patients were randomly assigned (1:1) to T-YT or T-PR groups in a parallel-arm single-blinded controlled trial. The primary outcome is 6MWD recorded at baseline and after three months and secondary outcomes were symptom scores, Forced expiratory volume in the first second (FEV1), health-related quality of life (HrQoL), and depression and anxiety scores. Assessments were conducted at baseline and at the end of the three-month study period with a sample size of 75 in each group. Results A total of 150 consecutive patients with COPD were randomly assigned to either the T-YT (n = 75) or T-PR (n = 75) group. Their mean ± SD ages was 62.5 ± 7.0 years. The T-YT group had 55.5% males and 34.47% females, whereas the T-PR group had 44.5% males and 61.53% females. The trial was completed by 123 patients; 88% in the T-YT group and 76% in the T-PR group. Pre-intervention, the median (range)of 6MWD in T-YT and T-PR groups was 240 (120-600) m and 240 (120-660) m, respectively. There was statistically significant improvement in both groups respectively (p<0.001) post intervention from baseline but no significant intergroup difference (p = 0.486). A similar trend was seen in secondary outcomes with significant intragroup improvements and non-significant inter-group differences except FEV1%, which showed neither intragroup nor intergroup significant improvement. Conclusion Using a validated module, a three-month T-YT improves exercise capacity, symptom scores, HrQoL, and depression and anxiety scores similar to T-PR. T-YT is an acceptable alternative toT-PR in the management of COPD.

Peer Support for Type 2 Diabetes Management in Low- and Middle-Income Countries (LMICs): A Scoping Review.

Although there is evidence of peer support in high-income countries, the use of peer support as an intervention for cardiometabolic disease management, including type 2 diabetes (T2DM), in low- and middle-income countries (LMICs), is unclear. A scoping review methodology was used to search the databases MEDLINE, Embase, Emcare, PsycINFO, LILACS, CDSR, and CENTRAL. Twenty-eight studies were included in this scoping review. Of these, 67% were developed in Asia, 22% in Africa, and 11% in the Americas. The definition of peer support varied; however, peer support offered a social and emotional dimension to help individuals cope with negative emotions and barriers while promoting disease management. Findings from this scopingreview highlight a lack of consistency in defining peer support as a component of CMD management in LMICs. A clear definition of peer support and ongoing program evaluation is recommended for future research.

Extracellular Vesicles in Malaria: Shedding Light on Pathogenic Depths.

Malaria, a life-threatening infectious disease caused by Plasmodium falciparum, remains a significant global health challenge, particularly in tropical and subtropical regions. The epidemiological data for 2021 revealed a staggering toll, with 247 million reported cases and 619,000 fatalities attributed to the disease. This formidable global health challenge continues to perplex researchers seeking a comprehensive understanding of its pathogenesis. Recent investigations have unveiled the pivotal role of extracellular vesicles (EVs) in this intricate landscape. These tiny, membrane-bound vesicles, secreted by diverse cells, emerge as pivotal communicators in malaria's pathogenic orchestra. This Review delves into the multifaceted roles of EVs in malaria pathogenesis, elucidating their impact on disease progression and immune modulation. Insights into EV involvement offer potential therapeutic and diagnostic strategies. Integrating this information identifies targets to mitigate malaria's global impact. Moreover, this Review explores the potential of EVs as diagnostic biomarkers and therapeutic targets in malaria. By deciphering the intricate dialogue facilitated by these vesicles, new avenues for intervention and novel strategies for disease management may emerge.

Impact of the circadian clock on cardiovascular physiology and pathophysiology

Circadian rhythms are the innate approximately 24-hour oscillations that orchestrate a multitude of physiological processes encompassing sleep-wake cycles, hormone secretion, thermoregulation, metabolism, and behavioral patterns. Also, those rhythms are intrinsically governed by the suprachiasmatic nucleus (SCN) ensconced in the anterior hypothalamic region. The SCN, synchronized during daylight hours receives and transmits diverse bodily signals to calibrate physiological dynamics, and imbue disturbances with potential repercussions reverberating across a plethora of physiological and behavioral domains. Previous studies have proven that the diurnal changes in the circadian rhythm multiple myocardial processes and have a critical impact on the physiology and pathophysiology of the cardiovascular system. This comprehensive review emphasizes the profound influence of circadian rhythms, orchestrated by the suprachiasmatic nucleus, on cardiovascular health. It reveals that disruptions in circadian rhythms impact blood pressure, myocardial function, platelet responsiveness, and the autonomic nervous system, all of which are critical for cardiovascular well-being. The significance of this research lies in its potential to guide interventions for cardiovascular disease prevention and management, particularly in the context of modern challenges like shift work. Understanding this intricate relationship is crucial for safeguarding cardiovascular health in our fast-paced world.

A PILOT FAMILY COACHING INTERVENTION FOR PEOPLE WITH TYPE 2 DIABETES AND A FAMILY MEMBER

Abstract Type 2 diabetes is a common chronic condition in later life that requires substantial lifestyle changes. Most diabetes management occurs at home with the help – and sometimes hindrance – of family members. Although coaching has become a common strategy in healthcare to supplement diabetes education, few interventions have prepared family members to be coaches, despite the documented benefit of including family members in chronic disease management interventions. The overall goal of our pilot intervention was to develop and test a family coaching approach to enhance patients’ diabetes self-management while preserving relationship quality and both individuals’ well-being. Participants were recruited from local diabetes education classes and through provider referrals, and included 20 dyads in the intervention group (patient Mage=59.12) and 20 dyads in the control group (patient Mage=57.06). The intervention, involving 5 interactive group sessions (in-person or virtual) led by a facilitator, covered evidence-based material developed by the investigators on diabetes education and coaching strategies. Behavioral, clinical, emotional, and relational metrics were assessed via a survey at baseline, post-intervention, and 3 months later; intervention participants also completed a program evaluation survey and participated in a focus group. Survey findings revealed some positive effects for diabetes self-management behaviors, no effects for short-term clinical markers, negative effects for emotional well-being, and both positive and negative effects for relational well-being. Participants reported being satisfied with the program overall; they indicated learning a lot and having a positive experience. A translation and cultural adaptation of this program for Spanish-speaking populations is currently underway.

Community nursing interventions for chronic disease management

Chronic illnesses present a hurdle in the field of healthcare in community settings. This review of existing literature delves into the role of community nursing interventions when it comes to managing diseases. It sheds light on their effectiveness challenges and potential areas for improvement. Chronic diseases like diabetes, cardiovascular conditions, and respiratory ailments contribute substantially to both mortality rates and morbidity levels. They also place a burden on healthcare systems. Community nursing interventions play a role in addressing these diseases in underserved and rural communities. These strategies include programs, self-management initiatives, home visits, telehealth services, and coordinated care. Research indicates that these approaches have been successful in improving outcomes and reducing the burden, on healthcare systems. To fully maximize the benefits of these interventions we need to overcome obstacles that come our way. Issues such as staffing shortages, the need for training among nurses involved in community care, and the seamless integration of technology must be addressed to optimize their effectiveness. To further advance the field of community nursing interventions for disease management, future research should focus on developing strategies to overcome these challenges effectively. In addition to evaluate the long-term impact of community nursing interventions to understand how effective they are.

Spousal Concordance of Hypertension Among Middle-Aged and Older Heterosexual Couples Around the World: Evidence From Studies of Aging in the United States, England, China, and India.

Health concordance within couples presents a promising opportunity to design interventions for disease management, including hypertension. We compared the concordance of prevalent hypertension within middle-aged and older heterosexual couples in the United States, England, China, and India. Cross-sectional dyadic data on heterosexual couples were used from contemporaneous waves of the HRS (US Health and Retirement Study, 2016/17, n=3989 couples), ELSA (English Longitudinal Study on Aging, 2016/17, n=1086), CHARLS (China Health and Retirement Longitudinal Study, 2015/16, n=6514), and LASI (Longitudinal Aging Study in India, 2017/19, n=22 389). Concordant hypertension was defined as both husband and wife in a couple having hypertension. The prevalence of concordant hypertension within couples was 37.9% (95% CI, 35.8-40.0) in the United States, 47.1% (95% CI, 43.2-50.9) in England, 20.8% (95% CI, 19.6-21.9) in China, and 19.8% (95% CI, 19.0-20.5) in India. Compared with wives married to husbands without hypertension, wives married to husbands with hypertension were more likely to have hypertension in the United States (prevalence ratio, 1.09 [95% CI, 1.01- 1.17), England (prevalence ratio, 1.09, 95% CI, 0.98-1.21), China (prevalence ratio, 1.26 [95% CI, 1.17-1.35), and India (prevalence ratio, 1.19 [95% CI, 1.15-1.24]). Within each country, similar associations were observed for husbands. Across countries, associations in the United States and England were similar, whereas they were slightly larger in China and India. Concordance of hypertension within heterosexual couples was consistently observed across these 4 socially and economically diverse countries. Couple-centered interventions may be an efficient strategy to prevent and manage hypertension in these countries.

Development and Functionality of a Parsimonious Digital Food Frequency Questionnaire for a Clinical Intervention among an Indigenous Population

Nutrition-related chronic diseases are a major problem among Indigenous populations. Appropriate dietary intake assessment tools are needed for nutritional surveillance and intervention; however, tools designed to measure the habitual dietary intake of Indigenous persons are largely lacking. We developed a digital food frequency questionnaire (FFQ) to measure habitual consumption among Australian Aboriginal adults and support personalized nutrition counseling. The primary contributors to energy, select nutrients, and inter-person variation (83 food groups) were identified from nationally representative 24 h recall (24HR) data, and they accounted for &gt;80% of the total intake and inter-person variation of the nutrients of interest. Based on community input, a meal-based FFQ format was adopted, with a main food/beverage list of 81 items and the capacity to report on &gt;300 additional items via the digital platform. The nutrient database was based on the Australian Food and Nutrient Database. Data for the first 60 study participants (70% female; median age: 48 years) were used to assess the FFQ’s utility. The participants’ median [IQR] reported energy intake (10,042 [6968–12,175] kJ/day) was similar to their median [IQR] estimated energy expenditure (10,197 [8636–11,551] kJ/day). Foods/beverages on the main FFQ list accounted for between 66% and 90% of the participants’ reported energy and nutrient intakes; the remainder came from participant-selected extra items. The digital FFQ platform provides a potentially valuable resource for monitoring habitual dietary intake among Aboriginal adults and supporting chronic disease prevention and management interventions.

The importance of family relationships for the health of underserved Appalachians: An application and extension of the biobehavioral family model.

Appalachia is characterized by many contextual stressors, including geographic, economic, and cultural barriers to healthcare. Guided by the biobehavioral family model (BBFM), an understanding of the influence of interpersonal relationships (i.e., marital and nonmarital relationships) on health outcomes could be critical to mitigating the region's contextual stressors. Data were collected from 2018 to 2019 among 243 participants across seven pop-up medical clinics in central and southern Appalachia 59% from rural Appalachian counties (rural Mage = 41, 66% women, 90% White; urban Mage = 36, 74% women, 82% White). A series of multivariate regression models were conducted for outcome measures (i.e., depression, pain, physical symptoms, number of conditions, and perceived health). The results suggest that family quality was significantly related to all outcome measures except for perceived health, whereas marital satisfaction was only significantly linked to physical symptoms. Rurality was not significantly associated with any outcome measures and only moderated the association between family quality and a number of conditions. These findings demonstrate the importance of nonmarital family relationships on health outcomes for people in Appalachia. Given the limited direct impact rurality in this sample, close relationships may be important for the health and well-being of all economically marginalized Appalachians regarding where they live. Given the cultural tendency for Appalachians to rely on family and kinship networks for healthcare support and the findings in this study, medical professionals should develop innovative programs to incorporate family into healthcare visits, and disease management interventions for people living in Appalachia. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Incidence, Prevalence, and Disease Management Impactability of High Utilization in an Adult Sickle Cell Medical Home

Background: Utilization in adults with sickle cell disease (SCD) is driven by a biopsychosocial mix of predictors. Disease management intervenes on the biopsychosocial determinants of health, partly to drive down avoidable ED visits and hospitalizations. We previously reported the effect of disease management interventions on SCD utilization among adults enrolled in an Adult Sickle Cell Medical Home (Blood)[i]. To further understand the impact of these interventions, we evaluated the incidence, prevalence, and impactability of case management within our Medical Home. Method: The sample includes distinct individuals enrolled in the Adult SCD Medical Home (N=537 in 2017, N=621 in 2018, N=558 in 2019, N=677 in 2020, N=577 in 2021, and N=604 in 2022). We analyzed the “CoVID Years” (2020-2022) separately from the “Pre-CoVID” years (2017-2019). Interventions in the Adult SCD Medical Home included: medical care by MDs, NPs, and nurses; behavioral health counseling by a licensed clinical social worker; case management by Community Health Workers (Patient Navigators), and prior authorization management by a reimbursement specialist, a licensed pharmacy tech. To perform the analysis, we defined High utilizers (vs moderate or low utilizers) as those with &amp;gt;$200,000 in annual medical charges each year between the years 2017-2021. We used the definition threshold to calculate the annual incidence of high utilization: the percentage of moderate or low utilizers in an index year who became high utilizers in the subsequent year. Similarly, the annual prevalence of high utilization was the percentage of all patients who were high utilizers in an index year. And the impactability of high utilization was the percentage of high utilizers in an index year who became moderate or low utilizers in the subsequent year. We calculated the annual high-utilization incidence, prevalence, and impactability for 2018-2022. Results: The annual program high-utilizer incidence, prevalence, and impactability are shown in Table 1. Utilization was stable from year to year, except at the intersection of pre-COVID and COVID years. The impactability score was 0-3.5%. We could not find good literature showing comparative annual changes in rates of impactability in diabetes, congestive heart failure, or vulnerable Medicaid populations. The graphs show individual patients' index and multiple subsequent utilization costs for those remaining in the cohorts (Classes) starting from 2017-2022 (Class of 2018), 2018-2022 (Class of 2019), 2019-2022 (Class of 2020), and 2020-2022 (Class of 2021). No statistical analyses were performed, but the trends were numerically down for all periods. Conclusion: An intense disease management program, as part of an Adult Sickle Cell Medical Home was associated with stable year-over-year high-utilizer percentage. It was also associated with a stable, low annual incidence of ‘new’ high utilizers, and a stable, low impactability among current high utilizers. We could not determine how these program rates compare with analogous rates in other chronic diseases. [i] Intensive Case Management in an Adult Sickle Cell Medical Home: Annual Effects on Utilization Efficiency Using Community Health Workers; Shirley Johnson, BA, LSW1*, Daniel M Sop, BS, MS2, Yue May Zhang, MS3*,Benjamin Jaworowski, BS 1*and Wally R Smith, MD4

Evaluation of patients engagement with a digital intervention for daily disease management in pulmonary arterial hypertension

Abstract Introduction Pulmonary arterial hypertension (PAH) is a chronic rare disease with a complex treatment that affects the daily life of patients and requires ongoing monitoring and assessment. In comparison with other chronic diseases, the application of digital health approaches to address patients’ needs in disease self-management has not been comprehensively studied [1], [2]. Within the framework of a clinical study, PAH patients’ engagement level and adherence to using a digital health platform have been studied. The platform allows patients to log health and lifestyle information while also providing structured content for patient education, medication reminders, and lifestyle coaching from a remote HC. Purpose The study aimed to measure the impact of the use of the platform on the Health-Related Quality of Life of the patients (HRQoL) and other clinical endpoints (patient’s functional status, signs and symptoms of PAH, patient costs and healthcare resource utilization) and also to assess patients’ engagement and satisfaction with the use of the platform. Method 53 PAH patients enrolled in a prospective, single cohort, multicentre study [3] from 5 specialized PAH units of reference public Spanish hospitals. The duration of the study was 6 months and to avoid interferences with routine clinical practice, clinical investigation visits matched the clinical guidelines for PAH patients in Spain, which recommend scheduling monitoring visits every 3-6 months. Questionnaires were administered to assess the QoL and satisfaction and for assessing the engagement levels, the app usage data has been analysed. Results Regarding the impact of platform usage for 6 months on the HRQoL and clinical endpoints of PAH patients, no statistically significant changes have been observed. However, as per the engagement, patients showed a great interest in using the app and connecting to the Health Coach (HC). More than 45% of patients finished 2 out of 4 levels of the structured educational content, 96.1% of patients used the activity logging feature. Over 79% of patients visited the app monthly and on average, the app was launched 1500 times per month. The communication between the patients and HC was steady during the study, another indication of adherence to the program. As per user experience, the overall outcomes of the questionnaire showed that 84.2% of patients considered that their needs have been met suggesting that the purpose of the program is well addressed. Additionally, 92.1% of patients were satisfied with the program and would use it again. Moreover, 94.7% of patients expressed that they would recommend the program to a PAH patient. Conclusion Elevated satisfaction and engagement levels of patients demonstrate that the digital intervention is useful for the patients and supports companionship and knowledge. In this context, the development of digital solutions provides opportunities to ensure continuous PAH patient care and patient empowerment.

Resting state functional connectivity changes following mindfulness-based stress reduction predict improvements in disease control for patients with asthma

BackgroundThe staggering morbidity associated with chronic inflammatory diseases can be reduced by psychological interventions, including Mindfulness-Based Stress Reduction (MBSR). Proposed mechanisms for MBSR’s beneficial effects include changes in salience network function. Salience network perturbations are also associated with chronic inflammation, including airway inflammation in asthma, a chronic inflammatory disease affecting approximately 10% of the population. However, no studies have examined whether MBSR-related improvements in disease control are related to changes in salience network function. MethodsAdults with asthma were randomized to 8 weeks of MBSR or a waitlist control group. Resting state functional connectivity was measured using fMRI before randomization, immediately post-intervention, and 4 months post-intervention. Using key salience network regions as seeds, we calculated group differences in change in functional connectivity over time and examined whether functional connectivity changes were associated with increased mindfulness, improved asthma control, and decreased inflammatory biomarkers. ResultsThe MBSR group showed greater increases in functional connectivity between salience network regions relative to the waitlist group. Improvements in asthma control correlated with increased functional connectivity between the salience network and regions important for attention control and emotion regulation. Improvements in inflammatory biomarkers were related to decreased functional connectivity between the salience network and other networks. ConclusionsIncreased resting salience network coherence and connectivity with networks that subserve attention and emotion regulation may contribute to the benefits of MBSR for patients with asthma. Understanding the neural underpinnings of MBSR-related benefits in patients is a critical step towards optimizing brain-targeted interventions for chronic inflammatory disease management.

Evaluation of the effectiveness of personal electronic health assistants in monitoring patients with chronic diseases

Introduction: Chronic diseases pose significant challenges in healthcare, which has driven the development of electronic health solutions. The effectiveness of these solutions in the management of diseases such as hypertension has generated interest, but further in-depth, evidence-based evaluation is required.Objective: The study aims to comprehensively evaluate how a customizable web platform, called "HyperVigilance", influences blood pressure control in hypertensive patients, considering additional variables such as patient satisfaction, quality of life and costs associated with treatment. In addition, the aim is to explore possible demographic factors that could moderate the results.Methodology: The study was conducted with a quasi-experimental research design that included an intervention group using the "HyperVigilance" platform and a control group receiving standard medical care. Statistical tests were applied and demographic factors such as age, gender and socioeconomic status were considered.Results: The use of the "HyperVigilance" platform resulted in a significant reduction in blood pressure, increased patient satisfaction and a marked improvement in quality of life, as well as a reduction in the costs associated with the treatment of hypertension.Conclusions: The study concludes that the "HyperVigilance" platform is effective in controlling blood pressure and improving quality of life in patients with hypertension. The results support the growing role of digital interventions in chronic disease management, but highlight the need for long-term studies and exploration of different populations for a more complete understanding of their impact.