Chronic Disease Management Interventions Research Articles

Short message services interventions for chronic disease management: A systematic review

IntroductionThe burden of chronic diseases has continued to grow globally. Technology has been used successfully in the management of chronic conditions through diagnosis, monitoring and education. This review aims to collate available evidence to evaluate the role of short message services (SMS), as an intervention, in patient participation in disease management of three common chronic diseases, i.e., Human Immunodeficiency Virus (HIV), Diabetes Mellitus (DM) and Chronic Obstructive Pulmonary Disease (COPD). Materials and methodThe review identified eight eligible studies in PubMed, Google Scholar and Cochrane library that assessed the effect of SMS interventions on self-management in HIV, DM and COPD. Outcomes of interest included adherence to the self-management plan, lifestyle modification (e.g., exercise and diet), clinical outcomes (e.g body mass index, blood glucose level, blood pressure), knowledge of disease, feasibility, acceptability, usability, and cost-effectiveness. ResultsAdherence, knowledge about their disease conditions, and feasibility/acceptability were assessed in eight, six and three studies, respectively. Improvements from pre- to post-intervention in adherence and clinical outcomes (including body mass index and blood glucose level) were recorded in eight and three studies. Patients reported having knowledge about their conditions and were willing to continue with the intervention (patient acceptability and usability). However, some patients complained they could not send response messages either due to technical issues or forgetfulness and no analysis of cost-effectiveness. ConclusionChronic conditions require long-term care and patients can be active participants in their care plan to improve their health. SMS interventions have been used successfully to encourage patient self-management, patient awareness, and treatment adherence in HIV, COPD, and DM. The SMS intervention has been applied in various research designs and disease conditions. Patients’ adherence and clinical conditions changed from pre- to post-intervention; however, more research is needed to elucidate the effect of SMS interventions in different countries, socioeconomic status and age groups, and chronic diseases.

Evidence-Based Interventions for High Blood Pressure and Glycemic Control Among Illinois Health Systems.

IntroductionEvidence-based interventions (referral, team-based care, self-management, and self-monitoring) for chronic disease management are well documented and widely used by Federally Qualified Health Centers (FQHCs). However, how these interventions are implemented varies substantially.MethodsThe Illinois Health Information Systems Survey was deployed to 49 FQHCs. Responses were grouped into 4 distinct policies, systems, and processes (P/S/P) categories: internal policies/workflows, huddles (brief meetings), electronic health record alerts/tracking tools, and case manager/coordinator interaction. Responses were then direct-matched to the 2016 Health Resources and Services and Administration Uniform Data System clinical quality indicator (QI) percent scores. Descriptive statistics were generated and level of significance (P < .05) was tested for hypertension and type 2 diabetes mellitus.ResultsThe total number of P/S/Ps in place for hypertension ranged from 0 to 13 (mean, 6.9) and 0 to 8 for diabetes (mean, 5.1). Meeting or exceeding the national mean QI percent score for controlled blood pressure (62.4%) was significant among FQHCs with 9 or more P/S/Ps compared with those with 8 or fewer P/S/Ps. A positive association in clinical QI percent score was found among organizations that had 3 or more P/S/Ps (for all 4 intervention areas), although none were significant.ConclusionAn assessment of the types of P/S/Ps used to implement evidence-based interventions for hypertension and diabetes management is a first in Illinois. Initial results support some relationship between the number of P/S/Ps implemented and clinical QI percent score for both hypertension and diabetes.

Impact of community pharmacist-led interventions in chronic disease management on clinical, utilization, and economic outcomes: An umbrella review

Chronic disease represents a significant burden to the United States (US) health care system, with approximately 50% of all adults in the US having one or more chronic disease conditions. Pharmacist-led chronic disease management interventions are of special interest since 80% of medical treatments involve the use of prescription drugs. Moreover, community pharmacists are among the most accessible health care professionals to provide care for populations with chronic diseases. The impact of care provided by community pharmacists isn't well defined, with interventions taking on diverse forms with varied effects on outcomes. The purpose of this review is to summarize evidence from secondary literature on community pharmacist-led chronic disease management interventions and the impact on clinical, utilization, and economic outcomes. We conducted a systematic search of systematic reviews, meta-analyses, and narrative reviews using MEDLINE via PubMed, EMBASE.com and Cochrane Library databases published between January 1, 2007 and October 17, 2017. The following data were extracted: citation details, review type, number of primary studies included, disease state, description of the intervention, outcomes assessed, and results. Our search strategy retrieved 2296 titles and abstracts of which 15 references met our inclusion criteria. Selected articles covered 7 main diseases -diabetes, asthma, chronic obstructive pulmonary disease (COPD), hypertension, heart failure, hyperlipidemia, and human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS). Community pharmacist-led interventions mostly consisted of patient consultations and education. In diabetes, interventions achieved significant reductions in hemoglobin A1c, total cholesterol, and low-density lipoprotein (LDL). Reviews also reported favorable reductions in blood pressure, improved medication adherence and reduced readmission rates in patients with heart failure, improved lung function in patients with respiratory conditions, and increased medication adherence in those with HIV/AIDs. Literature reporting economic and utilization outcomes were limited and mostly focused on pharmacy interventions in diabetes. In some cases, community pharmacy services demonstrated a decrease in medical and health care costs in patients with diabetes. We found that community pharmacists can improve clinical outcomes in a wide array of chronic diseases, including diabetes, hyperlipidemia, HIV/AIDS, cardiovascular and respiratory diseases. More robust studies are needed to further assess the impact of specific interventions on economic and utilization outcomes.

CHRONIC DISEASES IN MIDDLE-AGED ADULTS WITH SUBJECTIVE COGNITIVE DECLINE: UNITED STATES, 2015-2017

While adults aged 65 years and older are most at risk for chronic conditions, studies show that middle-aged adults aged 45–64 years also have growing numbers of comorbid chronic diseases. Regardless of age, managing chronic conditions requires decision-making abilities to manage treatments effectively. Symptoms of memory loss and confusion may impair a person’s ability to manage their health. This study examined chronic conditions in persons with subjective cognitive decline (SCD), defined as the self-reported experience of increased memory problems or confusion. Behavioral Risk Factor Surveillance System data from 2015–2017 were used to define SCD and disease status for eight chronic conditions (heart disease, stroke, cancer, arthritis, asthma, depression, diabetes, and chronic obstructive pulmonary disease) for adults 45–64 years from 49 states, District of Columbia, and Puerto Rico that collected data on cognitive decline. Among adults aged 45–64 years, 10.8% reported SCD. Among those with SCD, 77.4% had at least one chronic disease compared to 47.1% of those without SCD. Those with SCD had a higher prevalence for all eight conditions compared to those similarly-aged without SCD. Adults with at least one chronic condition were more likely to discuss their symptoms of SCD with a health care professional (54.2%) compared to those with no chronic conditions (30.3%). Poor management of chronic conditions can result in increased health care costs and might worsen existing symptoms of confusion and memory problems. Self-care interventions for chronic disease management should consider the importance of an individual’s cognitive status, including SCD.

INTEREST GROUP SESSION—KOREAN AND KOREAN AMERICAN AND AGING: UNDERSTANDING THE HEALTH AND WELL-BEING OF OLDER KOREAN AMERICANS FROM CULTURAL PERSPECTIVES

Despite tremendous progress in improving health in the U.S. in recent years, many ethnic minority populations still experience significant health disparity gaps that stem from a lack of valid research and culturally sensitive service infrastructures for those populations. Our previous research indicates that overwhelming numbers of older Korean Americans, a first-generation immigrant group, suffer not only from health issues but also from a lack of self-confidence and a feeling of social isolation because of language and cultural barriers. In addition, many older Korean Americans lack personal resources and health literacy to overcome those barriers when they attempt to access the complicated U.S. health care system. The purpose of this symposium is to promote the understanding of the health and well-being of older Korean Americans and identify their vulnerabilities and resilience. A series of five community-based studies of older Korean Americans conducted in multiple locations (e.g., FL, HI, TX, NY, CA, MD, VA, DC, MN, and IL) that covers diverse topics on health and well-being (e.g., health literacy, chronic disease management intervention, physical/mental/oral/cognitive health, end-of-life issues, diabetes, cancer, and dementia), using various methodologies (e.g., quantitative surveys, qualitative interviews, focus groups, and randomized controlled trials) will be presented. The issues of diversities and disparities will be discussed from the cultural perspectives, as well as implications for future research and practice.

Disease Management Interventions in Lower-Limb Peripheral Arterial Disease: Impact on Functional Status

Background: Peripheral arterial disease (PAD) is a chronic atherosclerotic cardiovascular disease that is associated with significant morbidity, mortality and reduced quality of life. Disease management interventions may improve outcomes for people with PAD. The aim is to systematically review and quantify the effects of non-pharmacological and non-surgical chronic disease management interventions targeting people with lower-limb PAD. Methods: An electronic search of bibliographic databases and registries using terms to identify PAD and disease management was conducted. Databases were searched from inception to November 2018. Main results: Twelve trials with a total of 1287 participants were included in this review. Mean age of participants ranged from 65 to 73 years and 57% were male. Treatment effects were observed on the following primary outcomes with very low quality evidence: WIQ speed [MD 7.14 (2.65, 11.62); 4 trials; n = 412 participants]; WIQ stair climbing [MD 9.74 (4.55, 14.93); n = 412 participants]; WIQ walking distance [MD 12.65 (7.07, 18.24); 4 trials; n = 412 participants] and six-minute walking distance [MD 5.20 (2.56, 7.84); 3 trials; n = 451 participants]. Conclusions: Disease management interventions may improve functional status based on very low quality evidence. Our conclusions must be qualified by several methodological deficiencies in the studies and interpreted with caution despite the effect demonstrated.

Self-Management Education Through mHealth: Review of Strategies and Structures.

BackgroundDespite the plethora of evidence on mHealth interventions for patient education, there is a lack of information regarding their structures and delivery strategies.ObjectiveThis review aimed to investigate the structures and strategies of patient education programs delivered through smartphone apps for people with diverse conditions and illnesses. We also examined the aim of educational interventions in terms of health promotion, disease prevention, and illness management.MethodsWe searched PubMed, Cumulative Index to Nursing and Allied Health Literature, Embase, and PsycINFO for peer-reviewed papers that reported patient educational interventions using mobile apps and published from 2006 to 2016. We explored various determinants of educational interventions, including the content, mode of delivery, interactivity with health care providers, theoretical basis, duration, and follow-up. The reporting quality of studies was evaluated according to the mHealth evidence and reporting assessment criteria.ResultsIn this study, 15 papers met the inclusion criteria and were reviewed. The studies mainly focused on the use of mHealth educational interventions for chronic disease management, and the main format for delivering interventions was text. Of the 15 studies, 6 were randomized controlled trials (RCTs), which have shown statistically significant effects on patients’ health outcomes, including patients’ engagement level, hemoglobin A1c, weight loss, and depression. Although the results of RCTs were mostly positive, we were unable to identify any specific effective structure and strategy for mHealth educational interventions owing to the poor reporting quality and heterogeneity of the interventions.ConclusionsEvidence on mHealth interventions for patient education published in peer-reviewed journals demonstrates that current reporting on essential mHealth criteria is insufficient for assessing, understanding, and replicating mHealth interventions. There is a lack of theory or conceptual framework for the development of mHealth interventions for patient education. Therefore, further research is required to determine the optimal structure, strategies, and delivery methods of mHealth educational interventions.

Sustaining knowledge translation interventions for chronic disease management in older adults: protocol for a systematic review and network meta-analysis

BackgroundFailure to sustain knowledge translation (KT) interventions impacts patients and health systems, diminishing confidence in future implementation. Sustaining KT interventions used to implement chronic disease management (CDM) interventions is of critical importance given the proportion of older adults with chronic diseases and their need for ongoing care. Our objectives are to (1) complete a systematic review and network meta-analysis of the effectiveness and cost-effectiveness of sustainability of KT interventions that target CDM for end-users including older patients, clinicians, public health officials, health services managers and policy-makers on health care outcomes beyond 1 year after implementation or the termination of initial project funding and (2) use the results of this review to complete an economic analysis of the interventions identified to be effective.MethodsFor objective 1, comprehensive searches of relevant electronic databases (e.g. MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials), websites of health care provider organisations and funding agencies will be conducted. We will include randomised controlled trials (RCTs) examining the impact of a KT intervention targeting CDM in adults aged 65 years and older. To examine cost, economic studies (e.g. cost, cost-effectiveness analyses) will be included. Our primary outcome will be the sustainability of the delivery of the KT intervention beyond 1 year after implementation or termination of study funding. Secondary outcomes will include behaviour changes at the level of the patient (e.g. symptom management) and clinician (e.g. physician test ordering) and health system (e.g. cost, hospital admissions). Article screening, data abstraction and risk of bias assessment will be completed independently by two reviewers. Using established methods, if the assumption of transitivity is valid and the evidence forms a connected network, Bayesian random-effects pairwise and network meta-analysis will be conducted. For objective 2, we will build a decision analytic model comparing effective interventions to estimate an incremental cost-effectiveness ratio.DiscussionOur results will inform knowledge users (e.g. patients, clinicians, policy-makers) regarding the sustainability of KT interventions for CDM. Dissemination plan of our results will be tailored to end-users and include passive (e.g. publications, website posting) and interactive (e.g. knowledge exchange events with stakeholders) strategies.Systematic review registrationPROSPERO CRD42018084810

Why Effective Interventions Do Not Work for All Patients: Exploring Variation in Response to a Chronic Disease Management Intervention.

Half of all Americans have a chronic disease. Promoting healthy behaviors to decrease this burden is a national priority. A number of behavioral interventions have proven efficacy; yet even the most effective of these has high levels of nonresponse. In this study, we explore variation in response to an evidence-based community health worker (CHW) intervention for chronic disease management. We used a convergent parallel design that combined a randomized controlled trial with a qualitative process evaluation that triangulated chart abstraction, in-depth interviews and participant observation. Eligible patients lived in a high-poverty region and were diagnosed with 2 or more of the following chronic diseases: diabetes, obesity, hypertension or tobacco dependence. There were 302 patients in the trial, 150 of whom were randomly assigned to the CHW intervention. Twenty patients and their CHWs were included in the qualitative evaluation. We found minimal differences between responders and nonresponders by sociodemographic or clinical characteristics. A qualitative process evaluation revealed that health behavior change was challenging for all patients and most experienced failure (ie, gaining weight or relapsing with cigarettes) along the way. Responders seemed to increase their resolve after failed attempts at health behavior change, while nonresponders became discouraged and "shut down." Failure is a common and consequential aspect of health behavior change; a deeper understanding of failure should inform chronic disease interventions.

Cost-effectiveness of a chronic disease management model for cirrhosis: Analysis of a randomized controlled trial.

In this follow-up study to a randomized controlled trial of a chronic disease management (CDM) model in cirrhosis, our aim was to assess the relative cost-effectiveness of this model compared with usual care during the 12-month study period, using incremental costs per death avoided as the primary outcome. Mean differences in hospitalization costs, deaths avoided, and change in Chronic Liver Disease Questionnaire (CLDQ) total scores were presented with 95% non-parametric bootstrapped confidence intervals. Results were also presented using a cost-effectiveness plane (CEP) and cost-effectiveness acceptability curve. The CDM intervention was more expensive, by 18 521 AUD per participant, but more effective (% of deaths at 12months: 10% vs 15% and 0.67units increase per patient in CLDQ total scores). The resultant incremental cost-effectiveness ratios were 370425 AUD per death avoided (95% confidence interval: -14564 AUD to 2059373 AUD) and 27547 AUD per unit improvement in the CLDQ total score (95% CI: 7455 AUD to 143874 AUD). The CEPs demonstrated some uncertainty around cost-effectiveness. The cost-effectiveness acceptability curves demonstrated that at willingness to pay values of 400000 AUD per additional death avoided and 40000 AUD per unit improvement in the CLDQ, there was at least a 70% probability of CDM being more cost-effective than usual care. At 24months, CDM was much more effective (12% less deaths but now also cheaper by 985 AUD per patient). The analysis of data from a randomized controlled trial suggests that the CDM intervention used is likely to be cost-effective, relative to usual care, due to fewer patient deaths.

A system dynamics approach to planning and evaluating interventions for chronic disease management

Studies have been reported on the applications of systems science to chronic disease management, but few, if any, have concentrated on chronic kidney disease (CKD). We examined the impact of a system dynamics approach to the evaluation of interventions in care of patients with CKD. We developed a stock flow simulation model and a multi-objective goal programming model. After calibrating the model, eight scenarios were analysed to measure intervention effects. Physician education (PE) had the most significant impact on reducing disease progression rate (DPR) from Stage 3 to Stage 4, while care coordination had a substantial impact on decreasing DPR Stage 4 to Stage 5. The addition of either CME or primary care team building to PE led to significant reductions in DPR for patients with Stage 3 CKD. The goal programming model indicated that a growing number of primary care physicians and care managers are needed to manage CKD patients overtime. This study showed that the stock flow model is a potentially powerful tool for supporting informed decision-making for planning and implementing interventions at various phases.

Digital Health Innovation: A Toolkit to Navigate From Concept to Clinical Testing.

Digital health technologies such as smartphone apps, Web-based platforms, and wearable devices are rapidly emerging as promising interventions for acute and chronic disease management, particularly in the field of cardiovascular medicine. However, there is limited guidance on how to effectively develop and rigorously test digital health interventions (DHIs). Through our experience with innovating Corrie, a smartphone-based app paired with a smartwatch and blood pressure monitor for myocardial infarction recovery in the acute setting, we aim to provide a toolkit for navigating the digital health technology development and clinical testing processes. The toolkit consists of 6 steps: step one emphasizes concept generation by defining a specific clinical problem and the existing solutions aimed to address it; step two aims to recruit a multidisciplinary team within an academic institution; step three leverages technology accelerators and industry partnerships; step four develops the digital health technology with continuous feedback from patient and family end-users; step five solicits feedback from a diverse array of stakeholders; and step six performs a clinical study at a single site that, if successful, rapidly scales to multiple sites. DHI development is often a complex and vastly uncharted territory. By exploring the steps we took from concept to clinical testing with the first cardiology CareKit app, we hope to provide useful insights to teams that are starting out on their path to digital health innovation. We emphasize the central importance of embracing transdisciplinary work to move from silos to synergy.

A systematic review of chronic disease management interventions in primary care

BackgroundPrimary and community care are key settings for the effective management of long term conditions. We aimed to evaluate the pattern of health outcomes in chronic disease management interventions for adults with physical health problems implemented in primary or community care settings.MethodsThe methods were based on our previous review published in 2006. We performed database searches for articles published from 2006 to 2014 and conducted a systematic review with narrative synthesis using the Cochrane Effective Practice and Organisation of Care taxonomy to classify interventions and outcomes. The interventions were mapped to Chronic Care Model elements. The pattern of outcomes related to interventions was summarized by frequency of statistically significant improvements in health care provision and patient outcomes.ResultsA total of 9589 journal articles were retrieved from database searches and snowballing. After screening and verification, 165 articles that detailed 157 studies were included. There were few studies with Health Care Organization (1.9% of studies) or Community Resources (0.6% of studies) as the primary intervention element. Self-Management Support interventions (45.8% of studies) most frequently resulted in improvements in patient–level outcomes. Delivery System Design interventions (22.6% of studies) showed benefits in both professional and patient-level outcomes for a narrow range of conditions. Decision Support interventions (21.3% of studies) had impact limited to professional-level outcomes, in particular use of medications. The small number of studies of Clinical Information System interventions (8.9%) showed benefits for both professional- and patient-level outcomes.ConclusionsThe published literature has expanded substantially since 2006. This review confirms that Self-Management Support is the most frequent Chronic Care Model intervention that is associated with statistically significant improvements, predominately for diabetes and hypertension.

A review of the availability and cost effectiveness of chronic obstructive pulmonary disease (COPD) management interventions in rural Australia and New Zealand.

Chronic obstructive pulmonary disease (COPD) is a chronic, progressive disease, which consumes a significant proportion of the Australian and New Zealand healthcare budget. Studies have shown that people living with COPD outside of urban areas have higher rates of hospitalisations. Two international reviews have demonstrated reduced hospital admissions and length of stay in people with COPD who participate in an integrated disease management program. However, most studies included in these reviews are in urban settings. The purpose of this review is to explore the type and cost-effectiveness of COPD management interventions located in rural or remote settings of Australia and New Zealand in order to inform planning and ongoing service development in the authors' local health district. Six databases and Google scholar were searched to find literature relating to the availability and cost-effectiveness of non-pharmaceutical interventions for the management of COPD in rural and remote areas of Australia and New Zealand. Two studies were found that met the inclusion criteria. Both studies had small sample sizes, were single intervention studies and showed a positive influence on variables such as number of hospital admissions and length of stay at 12 months post-intervention. However, because of the limited number of studies and the lack of homogeneity of interventions, no conclusions regarding availability and cost-effectiveness of COPD interventions in rural and remote areas of Australia and New Zealand could be drawn. Limited literature exists to inform planning and development of services for people with COPD living in rural and remote areas of Australia and New Zealand. Approximately 50% of pulmonary rehabilitation programs are situated in rural and remote locations in Australia and New Zealand. Outcomes from existing programs need to be reported in a consistent and coordinated manner to allow evaluation of health resource utilisation.

The feasibility and acceptability of nurse-led chronic disease management interventions in primary care: An integrative review.

To explore the feasibility and acceptability of nurse-led chronic disease management and lifestyle risk factor reduction interventions in primary care (general practice/family practice). Growing international evidence suggests that interventions delivered by primary care nurses can assist in modifying lifestyle risk factors and managing chronic disease. To date, there has been limited exploration of the feasibility and acceptability of such interventions. Integrative review guided by the work of Whittemore and Knafl (). Database search of CINAHL, Medline and Web of Science was conducted to identify relevant literature published between 2000-2015. Papers were assessed for methodological quality and data abstracted before thematic analysis was undertaken. Eleven papers met the inclusion criteria. Analysis uncovered four themes: (1) facilitators of interventions; (2) barriers to interventions; (3) consumer satisfaction; and (4) primary care nurse role. Literature supports the feasibility and acceptability of nurse-led interventions in primary care for lifestyle risk factor modification. The ongoing sustainability of these interventions rests largely on organizational factors such as funding, educational pathways and professional support of the primary care nursing role. Further robust research around primary care nurse interventions is required to strengthen the evidence base.

A systems thinking approach to prospective planning of interventions for chronic kidney disease care

Chronic kidney disease (CKD) is a growing health problem. Previous approaches to improve CKD care tend to focus on the linear relationships between a specific intervention and its effects on the target CKD population. The objective of this paper is to investigate how a systems thinking approach can support decision making on system-level interventions for chronic disease management. Our research team conducted a case study at an academic health-care organization. To support prospective planning of interventions at the study institution, we adopted a systems thinking approach in three phases: intervention structuring, causal loop modeling, and implementation planning. In the first phase, four potential interventions were proposed to address gaps in the current system. In the second phase, a causal loop diagram was developed to identify feedback loops and evaluate potential impacts of the interventions on patients and care providers. In the last phase, the analysis was linked to decision making on intervention implementation. Overall, this whole process based on systems thinking helped the health-care organization to holistically understand the impact of various components of their CKD care system. Furthermore, the findings from the qualitative modeling and analysis provided the leadership with insights into gaps in care and a way forward for implementing interventions more successfully and effectively.

Shared care across the interface between primary and specialty care in management of long term conditions.

Shared care has been used in the management of many chronic conditions with the assumption that it delivers better care than primary or specialty care alone; however, little is known about the effectiveness of shared care. To determine the effectiveness of shared care health service interventions designed to improve the management of chronic disease across the primary/specialty care interface. This is an update of a previously published review.Secondary questions include the following:1. Which shared care interventions or portions of shared care interventions are most effective?2. What do the most effective systems have in common? We searched MEDLINE, Embase and the Cochrane Library to 12 October 2015. One review author performed the initial abstract screen; then two review authors independently screened and selected studies for inclusion. We considered randomised controlled trials (RCTs), non-randomised controlled trials (NRCTs), controlled before-after studies (CBAs) and interrupted time series analyses (ITS) evaluating the effectiveness of shared care interventions for people with chronic conditions in primary care and community settings. The intervention was compared with usual care in that setting. Two review authors independently extracted data from the included studies, evaluated study quality and judged the certainty of the evidence using the GRADE approach. We conducted a meta-analysis of results when possible and carried out a narrative synthesis of the remainder of the results. We presented the results in a 'Summary of findings' table, using a tabular format to show effect sizes for all outcome types. We identified 42 studies of shared care interventions for chronic disease management (N = 18,859), 39 of which were RCTs, two CBAs and one an NRCT. Of these 42 studies, 41 examined complex multi-faceted interventions and lasted from six to 24 months. Overall, our confidence in results regarding the effectiveness of interventions ranged from moderate to high certainty. Results showed probably few or no differences in clinical outcomes overall with a tendency towards improved blood pressure management in the small number of studies on shared care for hypertension, chronic kidney disease and stroke (mean difference (MD) 3.47, 95% confidence interval (CI) 1.68 to 5.25)(based on moderate-certainty evidence). Mental health outcomes improved, particularly in response to depression treatment (risk ratio (RR) 1.40, 95% confidence interval (CI) 1.22 to 1.62; six studies, N = 1708) and recovery from depression (RR 2.59, 95% CI 1.57 to 4.26; 10 studies, N = 4482) in studies examining the 'stepped care' design of shared care interventions (based on high-certainty evidence). Investigators noted modest effects on mean depression scores (standardised mean difference (SMD) -0.29, 95% CI -0.37 to -0.20; six studies, N = 3250). Differences in patient-reported outcome measures (PROMs), processes of care and participation and default rates in shared care services were probably limited (based on moderate-certainty evidence). Studies probably showed little or no difference in hospital admissions, service utilisation and patient health behaviours (with evidence of moderate certainty). This review suggests that shared care improves depression outcomes and probably has mixed or limited effects on other outcomes. Methodological shortcomings, particularly inadequate length of follow-up, may account in part for these limited effects. Review findings support the growing evidence base for shared care in the management of depression, particularly stepped care models of shared care. Shared care interventions for other conditions should be developed within research settings, with account taken of the complexity of such interventions and awareness of the need to carry out longer studies to test effectiveness and sustainability over time.

Dementia and co-occurring chronic conditions: a systematic literature review to identify what is known and where are the gaps in the evidence?

The challenges posed by people living with multiple chronic conditions are unique for people with dementia and other significant cognitive impairment. There have been recent calls to action to review the existing literature on co-occurring chronic conditions and dementia in order to better understand the effect of cognitive impairment on disease management, mobility, and mortality. This systematic literature review searched PubMed databases through 2011 (updated in 2016) using key constructs of older adults, moderate-to-severe cognitive impairment (both diagnosed and undiagnosed dementia), and chronic conditions. Reviewers assessed papers for eligibility and extracted key data from each included manuscript. An independent expert panel rated the strength and quality of evidence and prioritized gaps for future study. Four thousand thirty-three articles were identified, of which 147 met criteria for review. We found that moderate-to-severe cognitive impairment increased risks of mortality, was associated with prolonged institutional stays, and decreased function in persons with multiple chronic conditions. There was no relationship between significant cognitive impairment and use of cardiovascular or hypertensive medications for persons with these comorbidities. Prioritized areas for future research include hospitalizations, disease-specific outcomes, diabetes, chronic pain, cardiovascular disease, depression, falls, stroke, and multiple chronic conditions. This review summarizes that living with significant cognitive impairment or dementia negatively impacts mortality, institutionalization, and functional outcomes for people living with multiple chronic conditions. Our findings suggest that chronic-disease management interventions will need to address co-occurring cognitive impairment. Copyright © 2017 John Wiley & Sons, Ltd.

Chronic disease management interventions for people with chronic kidney disease in primary care: a systematic review and meta-analysis.

Primary care providers manage the majority of patients with chronic kidney disease (CKD), although the most effective chronic disease management (CDM) strategies for these patients are unknown. We assessed the efficacy of CDM interventions used by primary care providers managing patients with CKD. The Medline, Embase and Cochrane Central databases were systematically searched (inception to November 2014) for randomized controlled trials (RCTs) assessing education-based and computer-assisted CDM interventions targeting primary care providers managing patients with CKD in the community. The efficacy of CDM interventions was assessed using quality indicators [use of angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB), proteinuria measurement and achievement of blood pressure (BP) targets] and clinical outcomes (change in BP and glomerular filtration rate). Two independent reviewers evaluated studies for inclusion, quality and extracted data. Random effects models were used to estimate pooled odds ratios (ORs) and weighted mean differences for outcomes of interest. Five studies (188 clinics; 494 physicians; 42 852 patients with CKD) were included. Two studies compared computer-assisted intervention strategies with usual care, two studies compared education-based intervention strategies with computer-assisted intervention strategies and one study compared both these intervention strategies with usual care. Compared with usual care, computer-assisted CDM interventions did not increase the likelihood of ACEI/ARB use among patients with CKD {pooled OR 1.00 [95% confidence interval (CI) 0.83-1.21]; I2 = 0.0%}. Similarly, education-related CDM interventions did not increase the likelihood of ACEI/ARB use compared with computer-assisted CDM interventions [pooled OR 1.12 (95% CI 0.77-1.64); I2 = 0.0%]. Inconsistencies in reporting methods limited further pooling of data. To date, there have been very few randomized trials testing CDM interventions targeting primary care providers with the goal of improving care of people with CKD. Those conducted to date have shown minimal impact, suggesting that other strategies, or multifaceted interventions, may be required to enhance care for patients with CKD in the community.

Adding non-randomised studies to a Cochrane review brings complementary information for healthcare stakeholders: an augmented systematic review and meta-analysis.

BackgroundTo reduce the burden of asthma, chronic disease management (CDM) programmes have been widely implemented and evaluated. Reviews including randomised controlled trials (RCTs) suggest that CDM programmes for asthma are effective. Other study designs are however often used for pragmatic reasons, but excluded from these reviews because of their design. We aimed to examine what complementary information could be retrieved from the addition of non-randomised studies to the studies included in a published Cochrane review on asthma CDM programmes, for healthcare stakeholders involved in the development, implementation, conduct or long-term sustainability of such programmes.MethodsExtending a previously published Cochrane review, we performed a systematic review (augmented review) including any type of study designs instead of only those initially accepted by Cochrane and the Effective Practice and Organization of Care Review group. After double data selection and extraction, we compared study and intervention characteristics, assessed methodological quality and ran meta-analyses, by study design.ResultsWe added 37 studies to the 20 studies included in the Cochrane review. The applicability of results was increased because of the larger variety of settings and asthma population considered. Also, adding non-randomised studies provided new evidence of improvements associated with CDM intervention (i.e. healthcare utilisation, days off work, use of action plan). Finally, evidence of CDM effectiveness in the added studies was consistent with the Cochrane review in terms of direction of effects.ConclusionsThe evidence of this augmented review is applicable to a broader set of patients and settings than those in the original Cochrane review. It also strengthens the message that CDM programmes have a beneficial effect on quality of life and disease severity, meaningful outcomes for the everyday life of patients with asthma. Despite the moderate to low methodological quality of all studies included, calling for caution in results interpretation and improvements in CDM evaluation methods and reporting, the inclusion of a broader set of study designs in systematic reviews of complex interventions, such as chronic disease management, is likely to be of high value and interest to patients, policymakers and other healthcare stakeholders.Electronic supplementary materialThe online version of this article (doi:10.1186/s12913-016-1816-5) contains supplementary material, which is available to authorized users.