In order to study the uncertainty optimization of the in-bore launching performance of larger-caliber artillery, the interior ballistic program was compiled and embedded in ABAQUS finite element software for secondary development, and the dynamic model of in-bore launching was built. The structural parameters of bore, the structural parameters of projectile and parameters of launching propellant were considered, and the uncertainty was described by interval number. BP neural network was used to construct a surrogate model for the dynamic model of in-bore launching. The deterministic transformation of uncertain objective function and uncertain constraints was carried out by using interval order model and interval probability model respectively. The interval uncertainty optimization model of the in-bore launching performance artillery was established by taking the interval radius and midpoint of the projectile muzzle velocity as objective functions and the maximum chamber pressure as constraint. Multi-objective genetic algorithm was used to solve the problem, and the optimal solution and reasonable interval of uncertain parameters were obtained.