This article is concerned with the integrated design of fault estimation (FE) and fault-tolerant control (FTC) for uncertain nonlinear systems suffering from actuator faults and external disturbance. The uncertain nonlinear systems are characterized as the interval type-2 (IT2) Takagi-Sugeno (T-S) fuzzy model, and IT2 membership functions are employed to effectively handle uncertainties. A fuzzy observer, utilizing only sampled-output measurements, is applied to simultaneously estimate actuator faults and system states. Based on the estimation, the fault-tolerant controller is designed to ensure the system stability under a predefined H∞ performance. The sampling behavior complicates the system dynamics and makes the integrated FTC design more challenging. To confront this issue, the discontinuous Lyapunov functional technique is exploited to enhance stability results by considering the sampling characteristic, upon which FE and FTC units are co-designed in the linear matrix inequality (LMI) framework. To further relax stability criteria, the analysis process incorporates the bound information of membership functions through the membership-function-dependent (MFD) method. Additionally, the relationship of mismatched premise variables resulting from the sampling scheme is also taken into account. Moreover, considering the imperfect premise matching (IPM) framework, the proposed fault-tolerant controller provides greater flexibility in selecting the shapes of membership functions and number of fuzzy rules that can vary from the counterpart of the fuzzy system. Finally, the efficacy of the proposed FTC technique is validated through a detailed numerical example.