Picture fuzzy C-means clustering is a novel computational intelligence method that has some advantages over fuzzy clustering in pattern analysis and machine intelligence. However, picture fuzzy clustering is easily affected by noise and weighting exponent, which seriously limits its widespread application. To address this issue, this paper proposes a new robust possibilistic clustering method called “interval type-2 possibilistic picture C-means clustering with local information”. This method combines interval type-2 fuzzy sets with possibilistic C-means clustering based on picture fuzzy sets, strengthening the noise resistance of picture fuzzy clustering. Firstly, this paper creatively extends an improved possibilistic clustering with double weighing exponents to picture fuzzy sets, solving the problem of consistency clustering in existing possibilistic picture clustering. Second, this paper originally introduces a new picture local information factor in possibilistic picture clustering and further enhances the anti-noise robustness of the method by using spatial possibilistic picture partition information. Finally, this paper skillfully extends this clustering method to interval type-2 fuzzy sets, which can handle more flexibly high-order uncertainties than type-1 clustering method. Experimental results indicate that this proposed method has better segmentation performance and stronger noise suppression ability compared with existing picture fuzzy clustering and interval type-2 fuzzy clustering. In summary, this work has made significant contributions to the development of picture fuzzy clustering theory and its applications.